Angelika Holler

Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion

Francesca Sillito, Elisa Armbrecht, Aideen T. O’Neill, Andrew McIntyre et autres

There is substantial interest in developing novel engineering strategies to promote the sustained metabolic fitness of therapeutic T cells. We previously showed that overexpression of RAS homologue enriched in brain (RHEB), a positive regulator of mammalian target of rapamycin complex 1 (mTORC1), …

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Incomplete T-cell tolerance and epitope-specific responses to the NR1 subunit in NMDA receptor antibody-associated encephalitis

Rachel Brown, Adriana S. Albuquerque, Sharyn Thomas, Angelika Holler et autres

Abstract NMDA receptor antibody-associated (NMDAR-Ab) encephalitis primarily affects young women and children and often requires prolonged intensive care admission. Currently available first- and second-line therapies are effective, but patients can be refractory and residual deficits are not uncommon. Although B-cell lineages and …

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LANA-specific CD4+ effector T cells accumulate at the site of KSHV infection in humanized mice

Michelle Böni, Shitao Peng, Danusia Vanoaica, Kareem Haal et autres

Abstract Kaposi’s sarcoma-associated herpesvirus (KSHV) infection is linked with the development of life-threatening malignancies in elderly and immunocompromised hosts, suggesting tight control of the infection by T cell responses. T cells against KSHV, however, are barely detectable in infected individuals, and the …

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LANA-specific CD4$^{+}$ effector T cells accumulate at the site of KSHV infection in humanized mice

Michelle Böni, Shitao Peng, Danusia Vanoaica, Kareem Haal et autres

Kaposi's sarcoma-associated herpesvirus (KSHV) infection is linked with the development of life-threatening malignancies in elderly and immunocompromised hosts, suggesting tight control of the infection by T cell responses. T cells against KSHV, however, are barely detectable in infected individuals, and the mechanisms …

Enhancement of mTORC1 Activity in Engineered Therapeutic CD4+ T Cells Amplifies Tumour Infiltration but Impairs Cytotoxicity

Francesca Sillito, Angelika Holler, Aideen T. O’Neill, Lauren A. Callender et autres

There is substantial interest in developing strategies to improve the intrinsic functions of engineered therapeutic T cells, for example by manipulating their metabolic fitness. Mammalian target of Rapamycin complex 1 (mTORC1) is a critical orchestrator of anabolic metabolism and effector functions in …

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Editor’s Note: Detection of Wilms’ Tumor Antigen–Specific CTL in Tumor-Draining Lymph Nodes of Patients with Early Breast Cancer

Roopinder Gillmore, Shao‐An Xue, Angelika Holler, Jaspal Kaeda et autres

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Exploitation of CD3ζ to enhance TCR expression levels and antigen-specific T cell function

Abdullah Degirmencay, Sharyn Thomas, Angelika Holler, Samuel Burgess et autres

The expression levels of TCRs on the surface of human T cells define the avidity of TCR-HLA/peptide interactions. In this study, we have explored which components of the TCR-CD3 complex are involved in determining the surface expression levels of TCRs in primary …

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Exploitation of CD3ζ to enhance TCR expression levels and antigen-specific T cell function

Abdullah Degirmencay, Sharyn Thomas, Angelika Holler, Hans J. Stauss

The expression levels of TCRs on the surface of human T cells define the avidity of TCR-HLA/peptide interactions. In this study, we have explored which components of the TCR-CD3 complex are involved in determining the surface expression levels of TCRs in primary …

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Supplementary Methods, Figures 1 - 7 from Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation

Pedro Veliça, Mathias Zech, Siân M. Henson, Angelika Holler et autres

Supplementary methods for flow cytometry and retroviral construct generation. Supplementary Figure 1. Expression of activated caspase-3 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 2. Expression of CD25 and CD69 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure …

Supplementary Methods, Figures 1 - 7 from Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation

Pedro Veliça, Mathias Zech, Siân M. Henson, Angelika Holler et autres

Supplementary methods for flow cytometry and retroviral construct generation. Supplementary Figure 1. Expression of activated caspase-3 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 2. Expression of CD25 and CD69 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure …

Data from Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation

Pedro Veliça, Mathias Zech, Siân M. Henson, Angelika Holler et autres

Abstract A key challenge in the field of T-cell immunotherapy for cancer is creating a suitable platform for promoting differentiation of effector cells while at the same time enabling self-renewal needed for long-term memory. Although transfer of less differentiated memory T cells …

Data from Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation

Pedro Veliça, Mathias Zech, Siân M. Henson, Angelika Holler et autres

Abstract A key challenge in the field of T-cell immunotherapy for cancer is creating a suitable platform for promoting differentiation of effector cells while at the same time enabling self-renewal needed for long-term memory. Although transfer of less differentiated memory T cells …