Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion
Francesca Sillito, Elisa Armbrecht, Aideen T. O’Neill, Andrew McIntyre et autres
There is substantial interest in developing novel engineering strategies to promote the sustained metabolic fitness of therapeutic T cells. We previously showed that overexpression of RAS homologue enriched in brain (RHEB), a positive regulator of mammalian target of rapamycin complex 1 (mTORC1), …
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The Journal of Immunology