Maarten Schim van der Loeff

Comments on: “A systematic review and meta‐analysis of cytology and HPV ‐related biomarkers for anal cancer screening among different risk groups”

Fernando Dias Gonçalves Lima, Maarten Schim van der Loeff

With great interest we read the article “A systematic review and meta-analysis of cytology and HPV-related biomarkers for anal cancer screening among different risk groups” by Clarke et al.1 In this review the authors provide an overview of the current literature on …

nl (code pays fourni par la source)

Mapping hematologists’ HIV testing behavior among lymphoma patients–A mixed-methods study

S Bogers, Hanne M. L. Zimmermann, Amie K. Ndong, Udi Davidovich et autres

BACKGROUND: HIV testing among patients with malignant lymphoma (PWML) is variably implemented. We evaluated HIV testing among PWML, and mapped factors influencing hematologists' testing behavior. MATERIALS: We conducted a mixed-methods study assessing HIV testing among PWML, factors influencing HIV testing and opportunities …

nl (code pays fourni par la source)

O06.4 Detection of Treponema pallidum DNA at various body locations as a proxy for infectiousness

Silvia Achia Nieuwenburg, Hélène Zondag, Sylvia M. Bruisten, Maarten Schim van der Loeff et autres

Background Syphilis is highly infectious, but it is unknown whether other anatomical sites than the primary infection site contribute to onward transmission. We aimed to evaluate the presence of Treponema pallidum ssp pallidum (TP) at various body locations of syphilis patients to …

nl (code pays fourni par la source)

O07.1 Treponema pallidum intra-patient homogeneity between various body locations in patients with infectious syphilis

Hélène Zondag, Silvia Achia Nieuwenburg, Alje P. van Dam, M Himschoot et autres

Syphilis, caused by Treponema pallidum subspecies pallidum (TP), is a complex multi-stage infectious disease. Systematic dissemination is known to occur within a few hours of transmission. We investigated the molecular variation of TP at various body locations within patients and assessed whether …

nl (code pays fourni par la source)

O20.2 Ertapenem is non-inferior to ceftriaxone for the treatment of anogenital gonorrhea: the NABOGO randomized double blind non-inferiority trial

Henry J.C. de Vries, Vita W. Jongen, T Heyman, Carolien M. Wind et autres

Background Neisseria gonorrhoeae (Ng) is a common sexually transmitted infection (STI). Emerging strains resistant to first-line ceftriaxone threaten Ng management. Hence, alternative treatments are needed. We evaluated the efficacy of ertapenem, gentamicin and fosfomycin as alternatives for Ng. Approach We included adults …

nl (code pays fourni par la source)

O11.3 Clinical improvement after treatment for urethritis: the role of Mycoplasma genitalium

Joyce F. Braam, Alje P. van Dam, SM Bruisten, M van Rooijen et autres

Introduction Mycoplasma genitalium (MG) is associated with urethritis in men. Treatment of urethritis with azithromycin is expected to become less effective in clients infected with MG due to an increase in macrolide resistance-associated mutations (MRAM) in MG. Therefore, we examined clinical improvement …

nl (code pays fourni par la source)

Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings

Stephen D Lawn, Catherine Seyler, Fabio Scano, Julian Elliott et autres

The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions …

P520 HPV infections and flat penile lesions of the penis in men who have sex with men

Ward van Bilsen, Alexandra Kovaleva, Maaike C.G. Bleeker, Audrey J. King et autres

Background Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods …

nl (code pays fourni par la source)

P615 Clinical improvement after standard treatment for urethritis: the role ofmycoplasma genitalium

Clarissa E. Vergunst, Maarten Schim van der Loeff, Martijn van Rooijen, Henry J.C. de Vries et autres

Background Mycoplasma genitalium (MG) is a sexually transmitted organism associated with urethritis in men. We examined clinical improvement of symptoms in men treated syndromically for urethritis, and correlated the clinical outcome to MG positivity. Methods At the STI clinic in Amsterdam, the …

nl (code pays fourni par la source)

P741 Detection oftreponema pallidumDNA at various body locations

Silvia Achia Nieuwenburg, Hélène Zondag, Sylvia M. Bruisten, Maarten Schim van der Loeff et autres

Background Syphilis is routinely diagnosed based on clinical findings and serological tests. Syphilis may be asymptomatic and in the early stages of infection serology may be false negative. This poses challenges in the diagnosis; missed infections may lead to onward transmission and …

nl (code pays fourni par la source)

Identification of productive and transforming anal intraepithelial neoplasia using immunohistochemical markers p16INK4a and HPV E4

Annemiek Leeman, David Jenkins, Elske Marra, Edyta C. Pirog et autres

Immunohistochemical (IHC) biomarkers enable standardised, reproducible grading of anal intraepithelial neoplasia (AIN) based on progression of HPV infection from transient productive infection to complete neoplastic transformation. We investigated the expression of IHC biomarker HPV E4, a marker of productive HPV infection, in …

nl, us (code pays fourni par la source)

LB1.67 Reduced susceptibility to ceftriaxone inneisseria gonorrhoeaein the netherlands recently predominantly found in association with an a501v/t mutation in the pena gene

Alje P. van Dam, Carolien M. Wind, Mirjam Dierdorp, Ikram Belhacen et autres

Introduction Neisseria gonorrhoeae (NG) resistance to ceftriaxone interferes with effective treatment of gonorrhoea. Ceftriaxone-resistant NG isolates have not yet been isolated in the Netherlands, but strains with reduced susceptibility to ceftriaxone (CTR-RS) have been cultured. Methods We compared 141 CTR-RS NG strains …

nl (code pays fourni par la source)