P520 HPV infections and flat penile lesions of the penis in men who have sex with men
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Le résumé fourni par la source
Background Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous study. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. If tested positive for HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and/or 59, we determined the HPV viral load (VL), using type-specific L1-targeting quantitative (q)PCR. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results We included 116 MSM, of whom 59/116 (51%) were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and in 34/62 (55%) MSM without FPL (p=0.8). Among MSM with FPL, 16/54 (30%) had an hrHPV infection and 23/54 (43%) had a lrHPV infection, which did not significantly differ from MSM without FPL (p=0.5 and p=0.4, respectively). A detectable HPV VL was found in 10/54 (19%) MSM with FPL and in 10/62 (16%) MSM without FPL (p=0.6). Among MSM with FPL, 27/54 (50%) were HIV-positive and 5/54 (9%) were circumcised, and among MSM without FPL, 32/62 (54%) were HIV-positive and 13/62 (21%) were circumcised (p=0.9 and p=0.09, respectively). Conclusion Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status, which is in contrast with findings among heterosexual males. Our findings imply that FPL are not useful in identifying HPV infections with a high transmission potential in this population. Disclosure No significant relationships.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- P520 HPV infections and flat penile lesions of the penis in men who have sex with men
- Date Crossref
- 01/07/2019
- Éditeur
- BMJ Publishing Group Ltd
- Type
- proceedings-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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GGD Amsterdam pays non établi dans la noticeÉtablissement de santé
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Amsterdam University Medical Centers pays non établi dans la noticeÉtablissement de santé
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Vrije Universiteit Amsterdam pays non établi dans la noticeUniversité ou école supérieure
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National Institute for Public Health and the Environment Center for Infectious Disease Control pays non établi dans la noticeStructure de recherche
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Public Health Service of Amsterdam pays non établi dans la noticeInstitution
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Vrije Universiteit-University Medical Center Amsterdam UMC pays non établi dans la noticeUniversité ou école supérieure
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DC Klinieken pays non établi dans la noticeInstitution
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Amsterdam University Medical Center (UMC) Public Health Service Amsterdam pays non établi dans la noticeUniversité ou école supérieure
GGD Amsterdam, Amsterdam University Medical Centers et Vrije Universiteit Amsterdam, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.