Fernando Dias Gonçalves Lima

Toward Objective Anal Cancer Screening: From Swab‐Based Genome‐Wide Methylation Marker Discovery to Novel Test Development

Kirsten Rozemeijer, Jürgen Claesen, Fernando Dias Gonçalves Lima, Albertus T. Hesselink et autres

Anal high-grade squamous intraepithelial lesions (HSIL:AIN2/3) are precursors to anal cancer, and early detection and treatment through screening is crucial for effective cancer prevention. Current guidelines recommend anal swab-based screening and highlight the need for objective biomarkers to improve risk stratification. While …

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Distinct tumor microenvironment profiles characterize regressive versus progressive anal precancers

Fernando Dias Gonçalves Lima, Marieke E. Ijsselsteijn, Johanna Verkerk, Kirsten Rozemeijer et autres

The R codes generated in this publication

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Distinct tumor microenvironment profiles characterize regressive versus progressive anal precancers

Fernando Dias Gonçalves Lima, Marieke E. Ijsselsteijn, Johanna Verkerk, Kirsten Rozemeijer et autres

The R codes generated in this publication

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Swab‐based anal cancer screening in men living with HIV : Projected outcomes for different screening algorithms

Kirsten Rozemeijer, Fernando Dias Gonçalves Lima, Esther J. Kuyvenhoven, Henry J.C. de Vries et autres

Screening for and treatment of anal cancer precursor lesions, high-grade squamous intraepithelial lesions (HSIL), can prevent anal cancer. Recent guidelines set by the International Anal Neoplasia Society recommend digital anal rectal examination (DARE) and anal swab-based screening of high-risk individuals by means …

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DNA Methylation Analysis on Anal Swabs for Anal Cancer Screening in People Living With Human Immunodeficiency Virus

Fernando Dias Gonçalves Lima, Kirsten Rozemeijer, Ramon P van der Zee, Stèfanie Dick et autres

BACKGROUND: High-resolution anoscopy (HRA) to prevent anal cancer is complex and screening capacity is limited. Previously, DNA methylation analysis of anal high-grade squamous intraepithelial lesion (HSIL) biopsies was shown to distinguish between HSIL with an increased and a low cancer risk, supporting …

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Uncovering the HPV types causing cervical cancer

Fernando Dias Gonçalves Lima, Mariano A. Molina

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Analytical validation and diagnostic performance of the ASCL1/ZNF582 methylation test for detection of high-grade anal intraepithelial neoplasia and anal cancer

Kirsten Rozemeijer, Fernando Dias Gonçalves Lima, Timo J. ter Braak, Albertus T. Hesselink et autres

DNA methylation testing on biopsies can detect high-grade anal intraepithelial neoplasia (HGAIN) in need of treatment and anal cancer. This study aimed to analytically validate and determine the diagnostic performance of a newly developed multiplex quantitative methylation-specific PCR, PreCursor-M AnoGYN(RUO), combining ASCL1, …

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Comments on: “A systematic review and meta‐analysis of cytology and HPV ‐related biomarkers for anal cancer screening among different risk groups”

Fernando Dias Gonçalves Lima, Maarten Schim van der Loeff

With great interest we read the article “A systematic review and meta-analysis of cytology and HPV-related biomarkers for anal cancer screening among different risk groups” by Clarke et al.1 In this review the authors provide an overview of the current literature on …

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DNA Methylation Analysis to predict Regression of high-grade anal Intraepithelial Neoplasia in HIV+ men (MARINE): a cohort study protocol

Fernando Dias Gonçalves Lima, Ramon P van der Zee, Stèfanie Dick, Carel J.M. van Noesel et autres

Introduction Anal cancer precursors, or high-grade anal intraepithelial neoplasia (HGAIN), are highly prevalent in HIV-seropositive (HIV+) men who have sex with men (MSM). Around 30% of lesions regress within 1 year, but current histopathological assessment is unable to distinguish between HGAIN likely …

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The Accuracy of Anal Swab–Based Tests to Detect High-Grade Anal Intraepithelial Neoplasia in HIV-Infected Patients: A Systematic Review and Meta-analysis

Fernando Dias Gonçalves Lima, Janine D Viset, Mariska Leeflang, Jacqueline Limpens et autres

BACKGROUND: The incidence of high-risk human papillomavirus (HR-HPV)-induced anal cancer is increasingly problematic among HIV-positive patients. Anal cancer is preceded by precursor lesions, anal intraepithelial neoplasia (AIN). AIN detection requires high-resolution anoscopy, a cumbersome and time-consuming procedure. We aggregated evidence on anal …

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The Acceptability of Pre-Exposure Prophylaxis: Beliefs of Health-Care Professionals Working in Sexually Transmitted Infections Clinics and HIV Treatment Centers

Janneke P. Bil, Elske Hoornenborg, Maria Prins, Arjan Hogewoning et autres

BACKGROUND: Pre-exposure prophylaxis (PrEP) is highly effective for preventing HIV infections, but is not yet implemented in the Netherlands. As the attitudes of health-care professionals toward PrEP can influence future PrEP implementation, we studied PrEP knowledge and beliefs and their association with …

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