Eric D. Green

The Effect of Green Tea Extract on Endurance Performance in Young Adults

Eric D. Green

Background: Green tea is rich in catechin, a polyphenolic antioxidant. Consumption of green tea or extract from green tea has been shown to result in weight loss, increased fat oxidation, and elevated energy expenditure in mice and humans. Green tea consumption has …

us (code pays fourni par la source)

Deborah A. Nickerson (1954 –2021)

Aravinda Chakravarti, Evan E. Eichler, Richard A. Gibbs, Eric D. Green et autres

In what was already a difficult year, 2021 ended on a somber note with the untimely death of Debbie Nickerson, a highly accomplished genomics researcher, a role model professional, and a long-time friend of Genome Research.Debbie Nickerson passed away at her home, …

us (code pays fourni par la source)

Recent Selection Changes in Human Genes under Long-Term Balancing Selection

Cesare de Filippo, Felix M. Key, Silvia Ghirotto, Andrea Benazzo et autres

Balancing selection is an important evolutionary force that maintains genetic and phenotypic diversity in populations. Most studies in humans have focused on long-standing balancing selection, which persists over long periods of time and is generally shared across populations. But balanced polymorphisms can …

de, it, us (code pays fourni par la source)

A global reference for human genetic variation

Adam Auton, Gonçalo R. Abecasis, David Altshuler, Richard M. Durbin et autres

© 2015 Macmillan Publishers Limited. All rights reserved. The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of …

A global reference for human genetic variation

Richard M. Durbin, Peter Donnelly, Paul Flicek, Eric D. Green et autres

The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 …

us, gb, ca, de, kr, cn, mo, dk, sa, hk, nl (code pays fourni par la source)

Disruption ofVisc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype

Peter L. Oliver, Rebecca A. Chodroff, Amrit Gosal, Benjamin Edwards et autres

Although long noncoding RNAs (lncRNAs) are proposed to play essential roles in mammalian neurodevelopment, we know little of their functions from their disruption in vivo. Combining evidence for evolutionary constraint and conserved expression data, we previously identified candidate lncRNAs that might play …

gb, us (code pays fourni par la source)

Integrative DNA, RNA, and Protein Evidence Connects TREML4 to Coronary Artery Calcification

Shurjo Kumar Sen, Kimberly C. Boelte, Jennifer J. Barb, Roby Joehanes et autres

us, nl (code pays fourni par la source)

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

Olivier Delaneau, Jonathan Marchini, Gil McVean, Peter Donnelly et autres

gb, us, it, ru (code pays fourni par la source)

Sequence Diversity of Pan troglodytes Subspecies and the Impact of WFDC6 Selective Constraints in Reproductive Immunity

Zélia Ferreira, Belén Hurlé, Aida M. Andrés, Warren W. Kretzschmar et autres

Recent efforts have attempted to describe the population structure of common chimpanzee, focusing on four subspecies: Pan troglodytes verus, P. t. ellioti, P. t. troglodytes, and P. t. schweinfurthii. However, few studies have pursued the effects of natural selection in shaping their …

us, pt, de, gb (code pays fourni par la source)

Reproduction and Immunity-Driven Natural Selection in the Human WFDC Locus

Zélia Ferreira, Susana Seixas, Aida M. Andrés, Warren W. Kretzschmar et autres

The whey acidic protein (WAP) four-disulfide core domain (WFDC) locus located on human chromosome 20q13 spans 19 genes with WAP and/or Kunitz domains. These genes participate in antimicrobial, immune, and tissue homoeostasis activities. Neighboring SEMG genes encode seminal proteins Semenogelin 1 and …

us, pt, de, gb (code pays fourni par la source)

Birth-and-Death of KLK3 and KLK2 in Primates: Evolution Driven by Reproductive Biology

Patrícia Marques, Rui Miguel Marques Bernardino, Teresa Matos Fernandes, Eric D. Green et autres

The kallikrein (KLK) gene family comprises the largest uninterrupted locus of serine proteases in the human genome and represents a notable case for studying the evolutionary fate of duplicated genes. In primates, a recent duplication event gave rise to KLK2 and KLK3, …

es, pt, us (code pays fourni par la source)

Specific inactivation of two immunomodulatory SIGLEC genes during human evolution

N. K. Mitra, Ismael Secundino, Kalyan Banda, Pedro Cruz et autres

Sialic acid-recognizing Ig-like lectins (Siglecs) are signaling receptors that modulate immune responses, and are targeted for interactions by certain pathogens. We describe two primate Siglecs that were rendered nonfunctional by single genetic events during hominin evolution after our common ancestor with the …

us, it, jp (code pays fourni par la source)