Junzheng Peng

Lung biopsy strategies for childhood interstitial lung disease: Indications and techniques

Kuimiao Deng, Lin Lin, Wenhao Zhou, Junzheng Peng

Childhood interstitial lung disease comprises a heterogeneous group of rare disorders where diffuse parenchymal involvement can cause chronic respiratory morbidity, pulmonary hypertension and death. Although advances in high-resolution computed tomography, immunological workup and genetic testing have improved diagnostic precision, many children remain …

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Renal Tubule-Specific Deletion of Angiotensinogen Gene Ameliorates Tubulopathy via Attenuation of Mitochondrial Dysfunction and Senescence in Akita Mouse Kidneys

Wenxia Yang, Min-Chun Liao, Junzheng Peng, M Yamashita et autres

Background: We have reported that renal tubule (RT)-specific angiotensinogen (Agt) gene deletion attenuates glomerular hyperfiltration, tubular injury, and urinary albumin-creatinine ratio, and decreases SGLT2 expression in T1D Akita mice (Diabetes 2025). The present study aimed to investigate if RT-deletion of Agt attenuates …

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Extracellular Vesicles of Salivary Mesenchymal Stem Cells Mitigate Acute Irradiation Injury: Use of an ex-vivo organotypic human slice tissue culture as a disease model

Akshaya Upadhyay, Migmar Tsamchoe, Anthony Zeitouni, Jordan Gigliotti et autres

Abstract Ionizing radiation (IR) therapy for cancer patients can damage surrounding healthy tissues, particularly the salivary glands (SGs), leading to oral and systemic health issues reducing the quality of life of the patients. The mechanisms behind IR damage in SGs are not …

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GPC3: a novel mutated gene in pleuropulmonary blastoma

Jiahang Zeng, Xinying Wang, Yingyi Xu, Qinglin Yang et autres

BACKGROUND: Pleuropulmonary blastoma (PPB) is a rare pediatric sarcoma often associated with DICER1 mutations. However, additional genetic factors may influence disease progression and prognosis. This study identifies a novel mutation in the GPC3 gene and evaluates its potential as a prognostic biomarker …

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Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes

Wenxia Yang, Ke Su, Min-Chun Liao, Jing Zhou et autres

The role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD) progression remains unclear. In this study, we generated mice with renal tubule-specific deletion of angiotensinogen (Agt; RT-Agt-/-) in both Akita and streptozotocin (STZ)-induced mouse model of diabetes. Both Akita …

Renal Tubule–Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes

Wenxia Yang, Ke Su, Min-Chun Liao, Jing Zhou et autres

The role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD) progression remains unclear. In this study, we generated mice with renal tubule (RT)-specific deletion of angiotensinogen (Agt; RT-Agt−/−) in both Akita and a streptozotocin (STZ)-induced mouse model of diabetes. …

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Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes

Wenxia Yang, Ke Su, Min-Chun Liao, Jing Zhou et autres

The role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD) progression remains unclear. In this study, we generated mice with renal tubule-specific deletion of angiotensinogen (Agt; RT-Agt-/-) in both Akita and streptozotocin (STZ)-induced mouse model of diabetes. Both Akita …

A twin with a novel mutation in CYBB induced X-linked chronic granulomatous disease: A rare case report of misdiagnosis as congenital cystic lung disease.

Lin Lin, Zongrong Gong, Genquan Yin, Gen Lu et autres

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Deficiency of Hedgehog Interacting Protein (Hhip) in Endothelial Cells Prevents Kidney Ischemia-Reperfusion-Mediated Renal Tubular Cell Senescence

Yuchao Pang, Junzheng Peng, Xin-Ping Zhao, Shiao‐Ying Chang et autres

Background: Acute kidney injury (AKI) caused by renal ischemia/reperfusion (R I/R) injury is a major clinical issue lacking viable therapies, and with incompletely delineated underlying mechanisms. Given the important roles of hedgehog interacting protein (Hhip) in glomerular endothelial cells (ECs), we asked …

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Deletion of Angiotensinogen in Renal Tubule Attenuates Diabetic Kidney Disease Progression in Diabetic Mice

Wenxia Yang, Ke Su, Jing Zhou, Min-Chun Liao et autres

Background: We previously reported that mice overexpressing angiotensinogen (AGT) in renal proximal tubular cells (RPTCs) developed hypertension and kidney injury Kidney Int. 2006). AGT is highly expressed in renal tubules (RTs) in mice and patients with diabetic kidney disease (DKD). We investigated …

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Deletion of Angiotensinogen in Renal Tubules Attenuates Tubular Senescence in Diabetic Kidney Disease

Wenxia Yang, Ke Su, Min-Chun Liao, Junzheng Peng et autres

Background: We reported previously that renal tubule (RT)-specific angiotensinogen (Agt) deletion attenuates kidney injury in type 1 diabetic Akita mice by reducing glomerular hyperfiltration, tubular injury score, urinary albumin-creatinine ratio and SGLT2 expression in renal proximal tubules (RPTs) (ASN’23, SA-PO423). Angiotensin II …

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Confocal structured illumination microscopy for improving the signal-to-noise ratio and depth of fluorescent optical section imaging

Weishuai Zhou, Manhong Yao, Xi Lin, Quan Yu et autres

Light scattering from the sample is an unavoidable problem in fluorescence imaging. Compared with laser scanning confocal scanning microscopy, although optical-sectioning structured illumination microscopy (OS-SIM) has the advantages of fast imaging speed and low phototoxicity, it faces the challenge of removing the …

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