Genquan Yin

ABS0211 SERGLYCIN: A PROMISING THERAPEUTIC TARGET FOR IDIOPATHIC INFLAMMATORY MYOPATHIES

J.Q. Zhang, Ying Tan, Z. Li, Jun Yang et autres

Background: Idiopathic inflammatory myopathy (IIM) is an autoimmune disease characterized by inflammation, progressive muscle weakness and elevated serum creatine kinase [1]. Currently, the immunosuppressive effect of drugs for treating IIM is limited, and the risk of adverse reactions is high [2]. Treatments …

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The assessment of dupilumab in children with moderate-to-severe asthma and comorbid type 2 inflammatory diseases

Tingting Shi, S.Y. Wu, Rongshan Chen, Yaping Xie et autres

Dupilumab inhibiting the signaling of interleukin(IL)-4 and IL-13 was recommended for the treatment of severe asthma in children ≥ 6 years old according to the Global Initiative for Asthma (GINA,2024).This study aimed to analyse the efficacy and safety of dupilumab in paediatric …

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A twin with a novel mutation in CYBB induced X-linked chronic granulomatous disease: A rare case report of misdiagnosis as congenital cystic lung disease.

Lin Lin, Zongrong Gong, Genquan Yin, Gen Lu et autres

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AB0241 ADENOSINE DEAMINASE 2 (ADA2) SERVES AS A NOVEL CLUE TO IDIOPATHIC INFLAMMATORY MYOPATHY (IIM)

Haiqiang Liu, Yurong Guo, Bijia Chen, Genquan Yin et autres

Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection: an observational study using two cohorts

Yuan-Yuan Pei, Hongli Wang, Genquan Yin, Yi Xu et autres

Abstract Background SARS-CoV-2 continues to mutate over time, and reports on children infected with Omicron BA.5 are limited. We aimed to analyze the specific symptoms of Omicron-infected children and to improve patient care. Methods We selected 315 consecutively hospitalized children with Omicron …

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Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China

Huifeng Fan, Li Huang, Diyuan Yang, Changhao Zhang et autres

BACKGROUND: X-linked hyper-immunoglobulin M (XHIGM), a primary immunodeficiency syndrome caused by mutations in the CD40 ligand gene(CD40LG), presents with recurrent respiratory infections in pediatric patients. We aimed to evaluate the spectrum of clinical features and respiratory pathogens in pediatric patients with XHIGM …

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OP002 [Infections » Other]: APPLICATION OF METAGENOMIC NEXT-GENERATION SEQUENCING (MNGS) IN DIAGNOSING PNEUMONIA OF CHILDREN

Yang Guo, Aimei Yang, Christine Chen, Yu‐Feng Hu et autres

Guo, Y.; Yang, A.; Chen, C.; Hu, Y.; Zheng, G.; Xie, Z.; Fan, H.; Sun, Y.; Xia, H.; Yin, G. Author Information

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Application of Metagenomic Next-Generation Sequencing (mNGS) Using Bronchoalveolar Lavage Fluid (BALF) in Diagnosing Pneumonia of Children

Aimei Yang, Chen Chen, Yan Hu, Guilang Zheng et autres

Our study indicates high efficiency of mNGS using BALF for the detection of causative pathogens that cause pneumonia in children. mNGS can be a potential diagnostic tool to supplement conventional methods for children's pneumonia.

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Two novel mutations in TCIRG1 induced infantile malignant osteopetrosis: a case report

Ping Wu, Zhe Cai, Wenhui Jiang, Gen Lu et autres

BACKGROUND: Infantile malignant osteopetrosis (IMO) is a rare autosomal recessive disease characterized by a higher bone density in bone marrow caused by the dysfunction of bone resorption. Clinically, IMO can be diagnosed with medical examination, bone mineral density test and whole genome …

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Peripheral immune profile of children with Talaromyces marneffei infections: a retrospective analysis of 21 cases

Qiang Zeng, Yingkang Jin, Genquan Yin, Diyuan Yang et autres

BACKGROUND: Talaromyces marneffei (T. marneffei) is an opportunistic pathogen that infects immunodeficient children. The aim of the study is to determine the clinical features and peripheral immune state of Talaromyces marneffei (T. marneffei) infections in children for early detection and diagnosis. METHODS: …

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Frequency of asthma exacerbation in children during the coronavirus disease pandemic with strict mitigative countermeasures

Huifeng Fan, Chunhui He, Genquan Yin, Yi Qin et autres

BACKGROUND: Strict countermeasures for coronavirus disease (COVID-19) were undertaken in China without knowing their influence on asthma. OBJECTIVE: To investigate the associations between the frequencies of asthma exacerbations and respiratory infections and air pollutants before and during the COVID-19 pandemic, which were …

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Differential proteomic analysis of children infected with respiratory syncytial virus

Genquan Yin, Huixuan Zeng, Zilong Li, Chen Chen et autres

Respiratory syncytial virus (RSV) infection is the main cause of lower respiratory tract infection in children. However, there is no effective treatment for RSV infection. Here, we aimed to identify potential biomarkers to aid in the treatment of RSV infection. Children in …

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