Jonathan Kennedy

The Impact of Self-Reported Health Factors on Behavioural Difficulties in School-Aged Children: Findings from the HAPPEN Pan-Wales Cohort Using Data Linkage

Michaela James, Amy Locke, Jonathan Kennedy, Mayara S. Bianchim et autres

Abstract This study aimed to examine factors associated with behavioural difficulties among school-aged children (aged 7 -11 years) using self-reported survey data linked to education data from a national cohort study of over 50,000 children (the HAPPEN national cohort) in Wales, UK, …

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Beyond Randomised Trials: Harnessing CARELINK Wales for Synthetic Control Evaluation in Child Healthcare

Jonathan Kennedy, Richmond Opoku, Evangelos Kontopantelis, Michaela James et autres

Synthetic control methods have emerged as a powerful tool for evaluating interventions in healthcare by constructing counterfactual scenarios that closely approximate outcomes in the absence of treatment. In the context of children in care, the application of synthetic controls offers a novel …

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Outcomes of Children Looked-After: Evidence from Growing Up in England

Richmond Opoku, Natasha Kennedy, Jonathan Kennedy, Dan Bristow et autres

Becoming looked-after by a local authority represents a major disruption in childhood and is linked to long term consequences for health and social outcomes. While the intention of taking children into care is to provide protection where remaining at home is unsafe, …

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Machine Learning in Colorectal Cancer Risk Prediction from Routinely Collected Data: A Review

Bruce Burnett, Shang‐Ming Zhou, Sinead T Brophy, Phil Davies et autres

The inclusion of machine-learning-derived models in systematic reviews of risk prediction models for colorectal cancer is rare. Whilst such reviews have highlighted methodological issues and limited performance of the models included, it is unclear why machine-learning-derived models are absent and whether such …

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Biochemical Characterization of a Novel Monospecific Endo-β-1,4-Glucanase Belonging to GH Family 5 From a Rhizosphere Metagenomic Library

Anna Wierzbicka-Woś, Ruth M. Henneberger, Ramón Alberto Batista‐García, Liliana Martínez-Ávila et autres

Cellulases have a broad range of different industrial applications, ranging from food and beverages to pulp and paper and the biofuels area. Here a metagenomics based strategy was used to identify the cellulolytic enzyme CelRH5 from the rhizosphere. CelRH5 is a novel …

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Diverse and Abundant Secondary Metabolism Biosynthetic Gene Clusters in the Genomes of Marine Sponge Derived Streptomyces spp. Isolates

Stephen A. Jackson, Lisa C. Crossman, Lekha Menon Margassery, Jonathan Kennedy et autres

The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these compounds are genetically encoded by large secondary metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which are modular and …

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Draft Genome Sequence of the Antimycin-Producing Bacterium Streptomyces sp. Strain SM8, Isolated from the Marine Sponge Haliclona simulans

Eduardo L. Almeida, Lekha Menon Margassery, Jonathan Kennedy, Alan D. W. Dobson

ABSTRACT Streptomyces sp. strain SM8, isolated from Haliclona simulans , possesses antifungal and antibacterial activities and inhibits the calcineurin pathway in yeast. The draft genome sequence is 7,145,211 bp, containing 5,929 predicted coding sequences. Several secondary metabolite biosynthetic gene clusters are present, …

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Maribacter spongiicola sp. nov. and Maribacter vaceletii sp. nov., isolated from marine sponges, and emended description of the genus Maribacter

Stephen A. Jackson, Jonathan Kennedy, John P. Morrissey, Fergal O’Gara et autres

Two Gram-stain-negative, rod-shaped, orange, catalase- and oxidase-positive, non-motile bacteria, designated W13M1A(T) and W15M10(T), were isolated from the marine sponges Suberites carnosus and Leucosolenia sp., respectively, which were sampled from Lough Hyne, Co. Cork, Ireland. Analysis of the 16S rRNA gene sequences of …

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Inhibition of the growth ofBacillus subtilisDSM10 by a newly discovered antibacterial protein from the soil metagenome

Mark O'Mahony, Ruth M. Henneberger, Joseph Selvin, Jonathan Kennedy et autres

A functional metagenomics based approach exploiting the microbiota of suppressive soils from an organic field site has succeeded in the identification of a clone with the ability to inhibit the growth of Bacillus subtilis DSM10. Sequencing of the fosmid identified a putative …

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Marine Sponges – Molecular Biology and Biotechnology

Alan D. W. Dobson, Stephen A. Jackson, Jonathan Kennedy, Lekha Menon Margassery et autres

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Marine Invertebrate Animal Metagenomics: Porifera

Jonathan Kennedy, Stephen A. Jackson, John P. Morrissey, Fergal O’Gara et autres

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A halotolerant thermostable lipase from the marine bacterium Oceanobacillus sp. PUMB02 with an ability to disrupt bacterial biofilms

George Seghal Kiran, Anuj Nishanth Lipton, Jonathan Kennedy, Alan D. W. Dobson et autres

A halotolerant thermostable lipase was purified and characterized from the marine bacterium Oceanobacillus sp. PUMB02. This lipase displayed a high degree of stability over a wide range of conditions including pH, salinity, and temperature. It was optimally active at 30 °C and …

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