Lekha Menon Margassery

Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101

Emmanuel Tope Oluwabusola, Stephen A. Jackson, Cristina Brutami, Stefanie Gackstatter et autres

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Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101

Emmanuel Tope Oluwabusola, Stephen A. Jackson, Cristina Brunati, Stefanie Gackstatter et autres

Using the one-strain-many-compounds (OSMAC) culturing approach, metabolomic studies, and bioassay-guided purification, we have isolated and characterised three new chlorinated natural products, agelolines B-D (1–3), together with two known compounds, ageloline A (4) and gausemycin A (5), which have been identified by high-resolution …

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Integration of microbial bioreactors and Lemna minor cultivation for sustainable treatment of dairy processing wastewater

Éamonn Walsh, Lekha Menon Margassery, Alejandro Rodríguez–Sánchez, David M. Wall et autres

A novel technological approach for dairy processing wastewater remediation is presented. This approach combines microbial bioreactor systems with Lemna minor plant biomass cultivation is presented. Sequential anaerobic and aerobic microbial batch reactors achieved wastewater remediation efficiencies of 97.5 %, 83 % and …

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Integration of Microbial Bioreactors and Lemna Minor Cultivation for Sustainable Treatment of Dairy Processing Wastewater

Éamonn Walsh, Lekha Menon Margassery, Alejandro Rodríguez–Sánchez, David M. Wall et autres

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Blue biotechnology – drugs from our o ceans

Lekha Menon Margassery

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The Effects of the Marine-Derived Polysaccharides Laminarin and Chitosan on Aspects of Colonic Health in Pigs Challenged with Dextran Sodium Sulphate

Ruth Rattigan, John V. O’Doherty, Stafford Vigors, Marion T. Ryan et autres

This study examined the effects of dietary supplementation with laminarin or chitosan on colonic health in pigs challenged with dextran sodium sulphate (DSS). Weaned pigs were assigned to: (1) a basal diet (n = 22); (2) a basal diet + laminarin (n …

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Microbial Population Changes in Decaying Ascophyllum nodosum Result in Macroalgal-Polysaccharide-Degrading Bacteria with Potential Applicability in Enzyme-Assisted Extraction Technologies

Maureen W. Ihua, Freddy Guihéneuf, Halimah O. Mohammed, Lekha Menon Margassery et autres

Seaweeds are of significant interest in the food, pharmaceutical, and agricultural industries as they contain several commercially relevant bioactive compounds. Current extraction methods for macroalgal-derived metabolites are, however, problematic due to the complexity of the algal cell wall which hinders extraction efficiencies. …

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Decaying Ascophyllum nodosum as a source of algal cell wall degrading enzymes with potential utility in enzyme-assisted extraction technologies

Maureen W. Ihua, Halimah O. Mohammed, Freddy Guihéneuf, Lekha Menon Margassery et autres

Seaweeds are of huge interest in the food, pharmaceutical and agricultural industries due to their high nutritional content and the prevalence of useful bioactive compounds. Current extraction methods of macroalgal-derived metabolites are however problematic due to the complexity of the algal cell …

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Diverse and Abundant Secondary Metabolism Biosynthetic Gene Clusters in the Genomes of Marine Sponge Derived Streptomyces spp. Isolates

Stephen A. Jackson, Lisa C. Crossman, Lekha Menon Margassery, Jonathan Kennedy et autres

The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these compounds are genetically encoded by large secondary metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which are modular and …

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Draft Genome Sequence of Pseudomonas putida CA-3, a Bacterium Capable of Styrene Degradation and Medium-Chain-Length Polyhydroxyalkanoate Synthesis

Eduardo L. Almeida, Lekha Menon Margassery, Niall D. O’Leary, Alan D. W. Dobson

strain CA-3 is an industrial bioreactor isolate capable of synthesizing biodegradable polyhydroxyalkanoate polymers via the metabolism of styrene and other unrelated carbon sources. The pathways involved are subject to regulation by global cellular processes. The draft genome sequence is 6,177,154 bp long …

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Draft Genome Sequence of the Antimycin-Producing Bacterium Streptomyces sp. Strain SM8, Isolated from the Marine Sponge Haliclona simulans

Eduardo L. Almeida, Lekha Menon Margassery, Jonathan Kennedy, Alan D. W. Dobson

ABSTRACT Streptomyces sp. strain SM8, isolated from Haliclona simulans , possesses antifungal and antibacterial activities and inhibits the calcineurin pathway in yeast. The draft genome sequence is 7,145,211 bp, containing 5,929 predicted coding sequences. Several secondary metabolite biosynthetic gene clusters are present, …

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Microbiome profiling of porcine susceptibility to experimental IBD among offspring of sows receiving seaweed extracts; evaluation of a maternal mode of dietary intervention

Lekha Menon Margassery, Stephen A. Jackson, Torres Sweeney, Alan D.W. Dobson et autres

Inflammatory Bowel Disease (IBD) affects more than 5 million people worldwide, with 1.4 million in the US and more than 3 million in Europe alone. It has been reported that IBD patients present an altered gut microbiome diversity compared with healthy individuals. …

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