Manabu Yamamoto

Laparoscopic resection of a cecal carcinoma with a Retzius vein shunt: A case report

Yusuke Kono, Manabu Yamamoto, Ryo Ishiguro, Takuki Yagyu et autres

RATIONALE: A Retzius shunt between the ileocecal vein and inferior vena cava is rare. To avoid major hemorrhage due to shunt injury, it is essential to evaluate vascular abnormalities on preoperative imaging and to confirm anatomic structures in detail during the operation. …

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New Treatment Modalities for Colorectal Cancer Through Simultaneous Suppression of FSP1 and GPX4

Yusuke Kono, Ryo Ishiguro, Takuki Yagyu, Kihara Kyoichi et autres

BACKGROUND/AIM: Ferroptosis is a nonapoptotic type of cell death that is dependent on iron and involves the accumulation of reactive oxygen species. Ferroptosis suppressor protein 1 (FSP1) and glutathione peroxidase 4 (GPX4) are ferroptosis regulators that inhibit ferroptosis through independent pathways. This …

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FOXP3 +/ CD8 + ratio associated with aggressive behavior in RUNX3 ‐methylated diffuse esophagogastric junction tumor

Suguru Maruyama, Yu Imamura, Tasuku Toihata, Ikumi Haraguchi et autres

The tumor immune microenvironment is increasingly becoming a key consideration in developing treatment regimens for aggressive cancers, with evidence that regulatory T cells (Tregs) attenuate the antitumor response by interrupting cytotoxic T cells (CD8+). Here, we hypothesized the prognostic relevance of the …

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BMP Signaling Is a Prognostic Marker in Patients With Colorectal Cancer and Associates With Frailty

Shohei Sawata, Shota Shimizu, Yoshiaki Matsumi, Yusuke Kono et autres

Background/Aim: Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β superfamily of ligands and have been shown to promote or suppress colorectal cancer (CRC) growth. Developing treatments that target BMPs is challenging due to their multiple roles, including involvement in …

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A new scoring system with simple preoperative parameters as predictors of early recurrence of pancreatic ductal adenocarcinoma

Tomonari Shimagaki, Keishi Sugimachi, Yohei Mano, Takahiro Tomino et autres

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) often recurs early after radical resection, and such early recurrence (ER) is associated with a poor prognosis. Predicting ER is useful for determining the optimal treatment. METHODS: One hundred fifty-three patients who underwent pancreatectomy for PDAC were …

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Prognostic significance of preoperative nutritional assessment in elderly patients who underwent laparoscopic gastrectomy for stage I–III gastric cancer

Hideo Uehara, Mitsuhiko Ota, Manabu Yamamoto, Tomonori Nakanoko et autres

Abstract Purpose: Surgery for elderly patients with gastric cancer is becoming more common. However, the risk factors of the laparoscopic surgery for these patients are unknown, and thus it is difficult to determine appropriate treatments for such patients. Methods: Two hundred twenty-two …

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Indications for conversion hepatectomy for initially unresectable colorectal cancer with liver metastasis

Masahiko Sugiyama, Hideo Uehara, Yuki Shin, Keiichi Shiokawa et autres

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Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses

Yu Imamura, Tasuku Toihata, Ikumi Haraguchi, Yoko Ogata et autres

Microsatellite instability (MSI) is categorized by mutation frequency: high MSI (MSI-H), low MSI (MSI-L) and microsatellite stable (MSS). MSI-H tumors have a distinct immunogenic phenotype, with immunotherapies using checkpoint inhibitors already approved for the treatment of MSI-H gastroesophageal adenocarcinoma (GEA); this is …

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Postoperative adjuvant therapy for patients with Pancreatic Neuroendocrine Neoplasms

Masayuki Hijioka, Tetsuhide Ito, Takashi Fujiyama, Toshihiko Miyahara et autres

膵神経内分泌腫瘍（PNEN）はホルモン産生能やGrade分類により，その病態や予後は大きく異なる．PNENはしばしば再発するが，特に高分化型の症例に対する術後補助療法は，エビデンスがなくガイドラインでも推奨されていないのが現状である．PNEN症例において，術後再発のリスクが高い症例を抽出すること，及びそれらの症例に対して術後補助療法が生命予後に寄与するかを明らかにしていくことが重要である．

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Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients

Yu Imamura, Masayuki Watanabe, Tasuku Toihata, Manabu Takamatsu et autres

BACKGROUND: The incidence trend of esophagogastric junction (EGJ) adenocarcinoma in Japan has not been sufficiently investigated. Little is known about the microsatellite instability (MSI) status of this tumor. SUMMARY: Previously published studies analyzing the trend of EGJ adenocarcinoma in Japan were reviewed. …

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Multidisciplinary treatments for hepatocellular carcinoma with major portal vein tumor thrombus

Sayaka Katagiri, Shun‐ichi Ariizumi, Yuko Kotera, Akiko Oomori et autres

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Benefits of laparoscopic surgery compared to open standard surgery for gastric carcinoma in elderly patients: propensity score-matching analysis

Manabu Yamamoto, Mototsugu Shimokawa, Hiroyuki Kawano, Mitsuhiko Ohta et autres

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