Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients
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Le résumé fourni par la source
BACKGROUND: The incidence trend of esophagogastric junction (EGJ) adenocarcinoma in Japan has not been sufficiently investigated. Little is known about the microsatellite instability (MSI) status of this tumor. SUMMARY: Previously published studies analyzing the trend of EGJ adenocarcinoma in Japan were reviewed. And a trend of surgically resected cases (Siewert type I-III) utilizing a retrospective multicenter cohort of 379 patients from 4 academic institutions in Japan investigated. Although an increasing trend in the last 2 reports was considered controversial, our cohort demonstrated a growing number of EGJ adenocarcinoma cases between 2006 and 2013. This trend was evident, especially in Siewert type I cases. In the previous 16 studies that performed MSI testing, MSI-high tumors ranged 0-8.3%, though there were no fixed microsatellite markers on EGJ adenocarcinoma. In a recent comprehensive genetic analysis by The Cancer Genome Atlas, MSI testing using the following 7 markers, BAT25, BAT26, BAT40, D2S123, D5S346, D17S250 and TGFR-II showed a favorable correlation with hypermutated tumors. We performed MSI testing using 6 of those markers, except TGFR-II, on 206 cases from one institution, and detected 15 cases (7.3%) with MSI-high. The prevalence of MSI-high was 0% in Siewert type I, 7.6% in type II, and 16.7% in type III. Key message: The number of surgically resected EGJ adenocarcinoma cases gradually increased, and MSI-high was infrequent in Siewert type I-II tumors in our Japanese cohort. Considering MSI-high as a predictive biomarker for emerging immune checkpoint inhibitors, MSI status is becoming more beneficial in EGJ adenocarcinoma.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients
- Date Crossref
- 14/12/2018
- Éditeur
- S. Karger AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Japanese Foundation For Cancer Research pays non établi dans la noticeOrganisation à but non lucratif
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Kumamoto University pays non établi dans la noticeUniversité ou école supérieure
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Kyushu University pays non établi dans la noticeUniversité ou école supérieure
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National Hospital Organization Kyushu Cancer Center Department of Pathology pays non établi dans la noticeÉtablissement de santé
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Cancer Institute Hospital of Japanese Foundation of Cancer Research Department of Gastroenterological Surgery pays non établi dans la noticeStructure de recherche
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Graduate School of Medical Sciences Department of Gastroenterological Surgery pays non établi dans la noticeUniversité ou école supérieure
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Cancer Institute of Japanese Foundation of Cancer Research Cancer Precision Medicine Center pays non établi dans la noticeStructure de recherche
Japanese Foundation For Cancer Research, Kumamoto University et Kyushu University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.