Accès ouvert
2025
article
OpenAlex
Allen S. W. Oak, Amrit Bagchi, Matthew J. Brukman, Joshua M. Toth et autres
Most wounds form scars without hair follicles. However, in the wound-induced hair neogenesis (WIHN) model of skin regeneration, wounds regenerate hair follicles if tissue rigidity is optimal. Although WIHN depends on Wnt signaling, whether Wnt performs a mechanoregulatory role that contributes to …
us
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Accès ouvert
2023
article
OpenAlex
Allen S. W. Oak, Chengxiang Fan, Ying Zheng, Arben Nace et autres
OBJECTIVES/GOALS: Current clinical practice recommends occlusive dressings (e.g., film and hydrocolloid) for wounds with variable regenerative capacities. However, clinical evidence suggests that occlusion may hinder regeneration. Our objective was to test the impact of occlusion on regeneration using animal models. METHODS/STUDY POPULATION: …
us
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Accès ouvert
2016
book-chapter
OpenAlex
Ying Zheng, Jen‐Chih Hsieh, Julia Escandon, George Cotsarelis
us
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Accès ouvert
2011
article
OpenAlex
Janet K. Lighthouse, Liqun Zhang, Jen‐Chih Hsieh, Thomas H. Rosenquist et autres
Abstract Low‐density lipoprotein receptor family mediated endocytosis in the mouse visceral endoderm. Photo shows a whole mount view of a E7.5 wild‐type embryo that was incubated with 50nM receptor associated protein (RAP) tagged with AlexaFluor 488 to visualize endocytosis in the visceral …
us
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Accès ouvert
2010
article
OpenAlex
Janet K. Lighthouse, Liqun Zhang, Jen‐Chih Hsieh, Thomas A. Rosenquist et autres
Deletion of the Mesd gene region blocks gastrulation and mesoderm differentiation in mice. MESD is a chaperone for the Wnt co-receptors: low-density lipoprotein receptor-related protein (LRP) 5 and 6 (LRP5/6). We hypothesized that loss of Wnt signaling is responsible for the polarity …
us
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2010
book-chapter
OpenAlex
Kurt S. Stenn, Ying Zheng, Jen‐Chih Hsieh
Accès ouvert
2009
article
OpenAlex
Adaobi Mofunanya, Feng‐Qian Li, Jen‐Chih Hsieh, Ken‐Ichi Takemaru
BACKGROUND: The Wnt/beta-catenin signaling pathway plays crucial roles in embryonic development and in maintenance of organs and tissues in adults. Chibby (Cby) is an evolutionarily conserved molecule that physically interacts with the key downstream coactivator beta-catenin and represses its transcriptional activation potential. …
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Accès ouvert
2008
article
OpenAlex
Janet K. Chang, Jen‐Chih Hsieh, Bernadette C. Holdener
us
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Accès ouvert
2007
article
OpenAlex
Fatma O. Kok, Emma Oster, Laura Mentzer, Jen‐Chih Hsieh et autres
us
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Accès ouvert
2006
article
OpenAlex
Guanghong Liao, Qinghua Tao, Matthew J. Kofron, Juei‐Suei Chen et autres
Jun NH(2)-terminal kinases (JNKs) regulate convergent extension movements in Xenopus embryos through the noncanonical Wnt/planar cell polarity pathway. In addition, there is a high level of maternal JNK activity spanning from oocyte maturation until the onset of gastrulation that has no defined …
us
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Accès ouvert
2004
article
OpenAlex
Jen‐Chih Hsieh
The highly conserved Wnt signaling proteins play critical roles in guiding pattern formation, cell fate decision, and morphogenetic movement during animal development. They bind to the Frizzled family of seven-pass transmembrane proteins and initiate at least three different intracellular signaling pathways, resulting …
us
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2003
article
OpenAlex
Christoph Wissmann, Peter Johannes Wild, Simone Kaiser, Stefan Roepcke et autres
To detect novel Wnt-pathway genes involved in tumourigenesis, this study analysed the RNA expression levels of 40 genes of the Wnt pathway by chip hybridization of microdissected matched pairs of 54 primary prostate carcinomas. Eleven genes showed greater than two-fold differential expression …
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