Arben Nace

Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia

Leo Wang, Spencer Tuohy, Elaine Kim, Arben Nace et autres

Minoxidil is the only FDA approved topical treatment for androgenetic alopecia, which is male- or female-pattern hair loss. However, its use is limited by its efficacy and tolerability. Here, we describe a novel bioengineered approach to improve local delivery to the skin. …

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Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration

Allen S. W. Oak, Amrit Bagchi, Matthew J. Brukman, Joshua Toth et autres

Most wounds form scars without hair follicles. However, in the wound-induced hair neogenesis (WIHN) model of skin regeneration, wounds regenerate hair follicles if tissue rigidity is optimal. Although WIHN depends on Wnt signaling, whether Wnt performs a mechanoregulatory role that contributes to …

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543 Controlled delivery of baricitinib to the skin through reversible thioimidate adducts

Leo Wang, Spencer Tuohy, Arben Nace, Kaiyuan Xu et autres

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Local and Sustained Baricitinib Delivery to the Skin through Injectable Hydrogels Containing Reversible Thioimidate Adducts (Adv. Healthcare Mater. 12/2024)

Leo Wang, Spencer Tuohy, Karen Xu, Arben Nace et autres

Hydrogel Use of Janus kinase (JAK) inhibitors in dermatology is associated with serious systemic toxicities. To overcome this, Leo L. Wang, George Cotsarelis, and co-workers show in article 2303256 that baricitinib, a nitrile-containing JAK inhibitor, is conjugated to a thiolated hydrogel network …

Local and Sustained Baricitinib Delivery to the Skin through Injectable Hydrogels Containing Reversible Thioimidate Adducts

Leo Wang, Spencer Tuohy, Karen Xu, Arben Nace et autres

Abstract Janus kinase (JAK) inhibitors are approved for many dermatologic disorders, but their use is limited by systemic toxicities including serious cardiovascular events and malignancy. To overcome these limitations, injectable hydrogels are engineered for the local and sustained delivery of baricitinib, a …

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83 Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of regeneration

Allen S. W. Oak, Chengxiang Fan, Ying Zheng, Arben Nace et autres

OBJECTIVES/GOALS: Current clinical practice recommends occlusive dressings (e.g., film and hydrocolloid) for wounds with variable regenerative capacities. However, clinical evidence suggests that occlusion may hinder regeneration. Our objective was to test the impact of occlusion on regeneration using animal models. METHODS/STUDY POPULATION: …

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Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development

Daniel Aldea, Blerina Kokalari, Yuji Atsuta, Heather L. Dingwall et autres

Enhancers are context-specific regulators of expression that drive biological complexity and variation through the redeployment of conserved genes. An example of this is the enhancer-mediated control of Engrailed 1 (EN1), a pleiotropic gene whose expression is required for the formation of mammalian …

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Differential modularity of the mammalian Engrailed 1 enhancer network directs eccrine sweat gland development

Daniel Aldea, Blerina Kokalari, Yuji Atsuta, Heather L. Dingwall et autres

Summary Enhancers are context-specific regulators of expression that drive biological complexity and variation through the redeployment of conserved genes. An example of this is the enhancer-mediated control of the transcription of Engrailed 1 ( EN1 ), a pleiotropic gene whose expression is …

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Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

Ruth Choa, Junichiro Tohyama, Shogo Wada, Hu Meng et autres

Sweat out the fat with TSLP! Thymic stromal lymphopoietin (TSLP) is a cytokine that can promote immune responses that characterize allergic diseases. Choa et al . found that mice engineered to produce elevated TSLP displayed selective white adipose tissue loss that protected …

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Thymic Stromal Lymphopoietin induces adipose loss through sebum hypersecretion

Ruth Choa, Junichiro Tohyama, Shogo Wada, Hu Meng et autres

Abstract Obesity is a serious public health concern. Emerging studies indicate that the immune system can regulate weight and energy homeostasis. Here we show that the cytokine Thymic Stromal Lymphopoietin (TSLP) stimulates T cells to induce selective white adipose loss, which protects …

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607 Cutaneous overexpression of cyclooxygenase-2 models androgenetic alopecia in adult mice

C. A. Hopkins, Yuzhong Zheng, R Yang, Arben Nace et autres

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The role of Thymic Stromal Lymphopoietin (TSLP) in protection from Type II diabetes

Ruth Choa, Shogo Wada, Hu Meng, Ruth-Anne Langan Pai et autres

Abstract Within the past 30 years, obesity and associated disorders such as Type II diabetes are rapidly becoming world-wide epidemics. Type II diabetes, caused by the loss of insulin sensitivity, accounts for $327 billion annually in the U.S. Recent studies have shown …

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