Alison Hayes

Horizontal transfer of nuclear DNA in transmissible cancer

Kevin Gori, Adrian Baez‐Ortega, Andrea Strakova, Maximilian R. Stammnitz et autres

Horizontal transfer of nuclear DNA between cells of host and cancer is a potential source of adaptive variation in cancer cells. An understanding of the frequency and significance of this process in naturally occurring tumors is, however, lacking. We screened for this …

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Horizontal transfer of nuclear DNA in transmissible cancer

Kevin Gori, Adrian Baez‐Ortega, Andrea Strakova, Maximilian R. Stammnitz et autres

Summary Although somatic cell genomes are usually entirely clonally inherited, nuclear DNA exchange between cells of an organism can occur sporadically by cell fusion, phagocytosis or other mechanisms 1–3 . This phenomenon has long been noted in the context of cancer, where …

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T-cell lymphoma involving the rectum of a dog

Alison Hayes, Katherine Hughes, Cassia Hare, Lorraine Peschard et autres

A mediastinal mass was diagnosed in a 7-year-4-month-old neutered female mixed breed dog following a 3-week history of lethargy, hyporexia and pyrexia. Bi-cavitary imaging, needle aspirate cytology and flow cytometry confirmed WHO clinical stage IVb, intermediate to large T-cell lymphoma involving the …

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Use of 3D Models in the Surgical Decision-Making Process in a Case of Double-Outlet Right Ventricle With Multiple Ventricular Septal Defects

Andrew I.U. Shearn, Michael Yeong, Michael D. Richard, Maria Victoria Ordoñez et autres

3D printing has recently become an affordable means of producing bespoke models and parts. This has now been extended to models produced from medical imaging, such as computed tomography (CT). Here we report the production of a selection of 3D models to …

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Imaging and Percutaneous Occlusion of a Large Aneurysm of the Ductus Arteriosus in an Infant with Loeys-Dietz Syndrome

Gareth J. Morgan, Deane Yim, Alison Hayes, Robin P. Martin et autres

Loeys-Dietz is a multisystem congenital syndrome that comprises craniofacial and cutaneous abnormalities as well as structural cardiac defects. One of its key pathological features is an aggressive widespread vasculopathy that can manifest as aortic or cerebral aneurysms, which is prone to dissection …

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Rectal lymphoma in 11 dogs – a retrospective study

Nils Van den Steen, Davide Berlato, Gerry Polton, Jane Dobson et autres

OBJECTIVES: To retrospectively evaluate the clinical behaviour and immunophenotype of lymphoma of the rectum in dogs. METHODS: Eleven dogs diagnosed with lymphoma of the rectum on histopathology were retrospectively reviewed. Immunohistochemistry with CD3 and CD79a antibodies was performed at diagnosis or retrospectively. …

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Clinical features, survival times and COX-1 and COX-2 expression in cats with transitional cell carcinoma of the urinary bladder treated with meloxicam

Nicholas X Bommer, Alison Hayes, T. Scase, Danièlle Gunn‐Moore

Records of 11 cats with transitional cell carcinoma of the urinary bladder, which had been treated with meloxicam, were reviewed for signalment, duration of clinical signs prior to diagnosis, results of diagnostic imaging, whether or not concurrent surgery was performed and survival. …

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Occlusion of Modified Blalock-Taussig Shunt After Clopidogrel Cessation

Vassilios S. Avlonitis, Sílvia Planas, Alison Hayes, Andrew Parry

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Mardini–Nyhan association (lung agenesis, congenital heart, and thumb anomalies): Three new cases and possible recurrence in a sib—Is there a distinct recessive syndrome?

Rob Hastings, David Harding, Alan Donaldson, Rachel Liebling et autres

In 1985, Mardini and Nyhan described three patients from consanguineous families with unilateral complete/partial lung agenesis, congenital cardiac defects, and ipsilateral thumb anomalies. Although there have been many reports of lung agenesis with other malformations, especially hemifacial microsomia and radial ray anomalies, …

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Influence of Tracheobronchomalacia on Outcome of Surgery in Children With Congenital Heart Disease and Its Management

Qiang Chen, Simon C Langton Hewer, Stephen C. Marriage, Alison Hayes et autres

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Early clinical experience with the new amplatzer ductal occluder II for closure of the persistent arterial duct

Jonathan Forsey, Damien Kenny, Gareth J. Morgan, Alison Hayes et autres

OBJECTIVES: To describe the early single-center clinical experience with the Amplatzer Ductal Occluder II (ADO II). METHODS: All patients undergoing attempted transcatheter closure of persistent arterial duct (PDA) with the ADO II were included. Data collected included demographic, clinical, and echocardiographic parameters. …

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Corneal squamous cell carcinoma in a Border Collie

Claudia Busse, Jane Sansom, Richard R. Dubielzig, Alison Hayes

A 6-year-old, female, spayed Border Collie was presented to the Unit of Comparative Ophthalmology at the Animal Health Trust with a 6-month history of a progressive nonpainful opacity of the left cornea. A keratectomy was performed and the tissue submitted for histopathology. …

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