Feiling Feng

Formic acid released by intratumoral Bacteroides thetaiotaomicron facilitates combinational therapy of Apatinib and aPD-1 in hepatocellular carcinoma

J J Lu, Feiling Feng, Chunlei Li, Ziqing Yu et autres

Through various murine models and 5R–16S sequencing, we identified Bacteroides thetaiotaomicron ( B.t ) as a sensitizer for the combined treatment of Apatinib and anti-PD-1 therapy. Clinically, B.t enrichment was associated with improved neoadjuvant treatment outcomes and a favorable prognosis in HCC …

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Development and validation of a machine learning–based postoperative staging system for hilar cholangiocarcinoma: a retrospective single-center cohort study

Qingxiang Gao, Y Q Wu, Gen Li, Feiling Feng et autres

BACKGROUND: Hilar cholangiocarcinoma (HCCA) is a malignant tumor at the hepatic hilum with poor prognosis and survival despite surgical resection. While existing staging systems, including AJCC, Gazzaniga T, MSKCC and Blumgart, provide prognostic frameworks, their predictive accuracy remains suboptimal. This study aimed …

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Corrigendum to “Trident-inspired fucoidan-based armor-piercing microcapsule for programmed acute pulmonary embolism treatment” [Colloids Surf. B. Biointerfaces 245 (2025) 114323]

Ning Yang, Weikun Li, Zhicheng Qian, Xin Tan et autres

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Establishment and characterization of two patient-derived cell lines from a patient with gallbladder carcinoma

Feiling Feng, Minghui Zhu, Yan Feng, Xiaoya Xu et autres

Background: The patient-derived primary cell line (PDC) exhibits similar biological characteristics to the original tumor tissue, and is a unique translational medicine tool for studying the growth, differentiation, metastasis and drug sensitivity of malignant tumor cells. However, due to the limited number …

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Injectable hydrogels based on mussel-inspired nanocomposite microspheres for non-compressible intra-abdominal hemorrhage control

Tao Liu, Peng Ma, Fengya Jing, Yinghua Tao et autres

This study presents a promising injectable hemostatic material for pre-hospital emergency hemorrhage control.

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Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders

Mao Yang, Yuhao Zhao, Chen Li, Xiaoling Weng et autres

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Mannose‐Glycated Metal‐Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy

Xin Tan, Renwang Sheng, Weikun Li, Yinghua Tao et autres

Abstract Microcapsules are advancing in immunotherapy, with both their core and shell being capable of loading immunoregulatory substances. Notably, microcapsules with intrinsic bioactivities can more directly modulate the immune microenvironment, while current research in this area remains scarce. Herein, immunomodulatory metal‐phenolic microcapsules …

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Multifunctional microneedle patch synergized with electrical stimulation to regulate microenvironment for enhanced healing of infected diabetic wounds

Weikun Li, Xin Tan, Yanling Liang, Nuoya Chen et autres

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Super‐Enhancer Reprograming Driven by SOX9 and TCF7L2 Represents Transcription‐Targeted Therapeutic Vulnerability for Treating Gallbladder Cancer

Siyuan Yan, Zhaonan Liu, Teng Wang, Yi Sui et autres

Gallbladder cancer (GBC) is a highly aggressive malignancy lacking clinically available targeted therapeutic agents. Super-enhancers (SEs) are crucial epigenetic cis-regulatory elements whose extensive reprogramming drives aberrant transcription in cancers. To study SE in GBC, the genomic distribution of H3K27ac is profiled in …

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Spatial multiomics reveals a subpopulation of fibroblasts associated with cancer stemness in human hepatocellular carcinoma

Siyu Jing, Dan Liu, Na Feng, Hui Dong et autres

BACKGROUND: Cancer-associated fibroblasts (CAFs) are the prominent cell type in the tumor microenvironment (TME), and CAF subsets have been identified in various tumors. However, how CAFs spatially coordinate other cell populations within the liver TME to promote cancer progression remains unclear. METHODS: …

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Tannic acid-crosslinked gelatin composite microspheres adsorbed with CQAS or Ca2+ for rapid hemostasis

Guanhua Jiao, Dandan Wei, Liuxin Yang, Yinghua Tao et autres

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DendroX: multi-level multi-cluster selection in dendrograms

Feiling Feng, Qiaonan Duan, Xiaoqing Jiang, Xiaoming Kao et autres

BACKGROUND: Cluster heatmaps are widely used in biology and other fields to uncover clustering patterns in data matrices. Most cluster heatmap packages provide utility functions to divide the dendrograms at a certain level to obtain clusters, but it is often difficult to …

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