Pingwei Zhao

Increases in serum corticosterone level and diuresis induced by the selective kappa opioid receptor (KOR) agonist U50,488H are unaffected by KOR phosphorylation

Pingwei Zhao, Kathryn Bland, Sanjana Khandeshi, Peng Huang et autres

Purpose: We previously showed that mice expressing a phosphorylation-deficient kappa opioid receptor mutant (K4A) exhibited reduced U50,488H-induced anti-scratching tolerance in males and reduced conditioned place aversion in females, without changes in acute anti-scratching or hypo-locomotor effects. Here, we examined whether K4A mutations, …

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Unveiling the hidden dance: SPP1 + macrophages identified in ulcerative colitis reveal crosstalk with CHI3L1 + fibroblasts

Peiwen Zhou, Tongyu Tang, Pingwei Zhao, Quan Wang et autres

BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon. The specific cause of UC is still not fully understood, but this condition is believed to arise from a combination of environmental, genetic, microbial, and …

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Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics

Haylee R. Hammond, Prakash Chaudhari, Ashley Bunnell, Khadija Nefzi et autres

Heterocyclic peptidomimetics are constrained compounds that mimic the biological efficacy of peptides while offering increased stability. We have previously generated a diazaheterocyclic peripherally selective, mixed-opioid agonist peptidomimetic that produced synergistic antinociception with decreased side effects. Working from two earlier templates, we report …

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Pharmacological characterization of the novel selective kappa opioid receptor agonists 10-Iodo-Akuammicine and 10-Bromo-akuammicine in mice

Kathryn Bland, Chongguang Chen, Peng Huang, Conrad K. Ho et autres

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Clavulanic acid inhibits methamphetamine locomotor sensitization in mice and normalizes methamphetamine-induced changes in glutaminase mRNA levels in the nucleus accumbens

T. Walters, Sonita Wiah, Aryan Shekarabi, Mia Milton et autres

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RPTOR mutation: a novel predictor of efficacious immunotherapy in melanoma

Yanfang Jiang, Xintong Hu, Zhouyu Wang, Qin Zhang et autres

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Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes

Ryo� Saito, Qianru Mu, Yu Yuan, Marcos Rubio‐Alarcón et autres

TPC2 is a pathophysiologically relevant lysosomal ion channel that is activated directly by the phosphoinositide PI(3,5)P 2 and indirectly by the calcium ion (Ca 2+ )–mobilizing molecule NAADP through accessory proteins that associate with the channel. TPC2 toggles between PI(3,5)P 2 -induced, …

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Cannabinoid mechanisms contribute to the therapeutic efficacy of the kratom alkaloid mitragynine against neuropathic, but not inflammatory pain

Daniel Farkas, Saadet Inan, Laila N. Heydari, Clare T. Johnson et autres

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In Memoriam of Professor Mary E. Abood

Eugen Brailoiu, Linda Console‐Bram, Pingwei Zhao

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Troriluzole inhibits methamphetamine place preference in rats and normalizes methamphetamine-evoked glutamate carboxypeptidase II (GCPII) protein levels in the mesolimbic pathway

Sonita Wiah, Abi Roper, Pingwei Zhao, Aryan Shekarabi et autres

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Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure–Activity Relationship

Laura Figuerola-Asencio, Paula Morales, Pingwei Zhao, Dow P. Hurst et autres

GPR55 is an orphan G-protein coupled receptor involved in various pathophysiological conditions. However, there are only a few noncannabinoid GPR55 ligands reported so far. The lack of potent and selective GPR55 ligands precludes a deep exploration of this receptor. The studies presented …

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Associations of C‑X‑C motif chemokine ligands 1/2/8/13/14 with clinicopathological features and survival profile in patients with colorectal cancer

Xiaofan Luo, Jiandong Tai, Yuhang Zhao, Pingwei Zhao et autres

The present study aimed to assess the correlation of C-X-C motif chemokine ligand (CXCL)1, CXCL2, CXCL8, CXCL13 and CXCL14 with clinicopathological features and survival profile in patients with colorectal cancer (CRC). Patients with primary CRC (n=232) were retrospectively reviewed, with their tumor …

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