Yousheng Wu

Hierarchical Studies in TRAP2 Mice Demonstrate that Neuronal Activation and Mitochondrial Networks Integration Constitute the Key Mechanism Underlying Painful Syncope

Xueyin Pu, Yulu Xia, Ziwei Ni, Changlei Zhu et autres

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Reduced mitochondrial Rab32 impairs mitochondria-endoplasmic reticulum contacts and inhibits apoptosis in hepatocellular carcinoma cells

Xiacheng Sun, X Liu, Qichao Huang, Jing Liu et autres

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The MCU-MECOM Axis Orchestrates Glioblastoma Progression by Remodeling Mitochondrial Dynamics and Quality Control via MAMs

Xiaodong Li, Yaoliang Wang, Feifei Wu, Xin Huang et autres

Glioblastoma (GBM) exhibits metabolic plasticity, relying on mitochondrial oxidative phosphorylation (OXPHOS) to support migration and therapy resistance. Although mitochondrial calcium overload typically induces apoptosis, GBM cells maintain viability under high calcium conditions. The structural and metabolic coupling mechanisms underlying this adaptation remain …

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IGF2BP1 positively regulates CircOGDH accumulation in hypoxia induced stress granules

Xuanlin Su, Jiankun Zang, Shiqing Zhang, Ping Wu et autres

The ischemic penumbra is critical in acute ischemic stroke (AIS) treatment, yet the regulation of precise RNA modification pathways remains unclear. Using a mouse model of ischemic stroke and human postmortem brain samples, we demonstrate that N 6- methyladenosine (m 6 A) …

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Pharmacological and Genetic Approaches to Downregulate FIS1 Mitigate Neuropathic Pain

Shu‐Jiao Li, Zhipeng Lin, Zi-Wei Ni, Ke Tian et autres

Despite the established link between neuropathic pain and abnormal mitochondrial fission in neurons, the specific role of mitochondrial fission protein 1 (FIS1) in this process remains to be fully elucidated. In this study, the subjects we investigated were 6-8-week-old male mice. Comprehensive …

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The association of lead and cadmium exposure with periodontitis: a systematic review and meta-analysis

Saiyan Yang, Jie Li, Yousheng Wu

OBJECTIVE: Periodontitis, a microbiome-driven chronic inflammatory disease that destroys the supporting structures of the teeth, is influenced by various environmental factors, including exposure to heavy metals such as lead and cadmium. This systematic review and meta-analysis aimed to evaluate the association between …

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Small Extracellular Vesicles From Hypoxia-Neuron Maintain Blood-Brain Barrier Integrity

Wei R. Chen, Yousheng Wu, Xuanlin Su, Man Ke et autres

BACKGROUND: Acute ischemic stroke disrupts communication between neurons and blood vessels in penumbral areas. How neurons and blood vessels cooperate to achieve blood-brain barrier repair remains unclear. Here, we reveal crosstalk between ischemic penumbral neurons and endothelial cells (ECs) mediated by circular …

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Research on exosomes and neurodevelopmental disorders

Yuhan Liu, Xueting Yang, Zhangying Chen, Feifei Wu et autres

Exosomes are vesicles that are encapsulated by intracellular somatic membranes and released into the extracellular environment.These vesicles contain biological macromolecules such as proteins, lipids, and nucleic acids, and can participate in a variety of biological processes such as cell-to-cell communication, transportation, and …

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FIS1 alleviates neuropathic pain by inhibiting mitochondrial fragmentation

Shu‐Jiao Li, Zhipeng Lin, Zi-Wei Ni, Ke Tian et autres

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Targeted downregulation of FIS1 in excitatory neurons within the spinal dorsal horn alleviates neuropathic pain through the mitigation of mitochondrial fragmentation

Shu‐Jiao Li, Zhipeng Lin, Zi-Wei Ni, Ke Tian et autres

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Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling

Xiaodong Li, Jing-Jing Tie, Yuze Sun, Chengrong Gong et autres

Abstract Background The dynamics of mitochondrial respiratory cristae (MRC) and its impact on oxidative phosphorylation (OXPHOS) play a crucial role in driving the progression of high-grade glioma (HGG). However, the underlying mechanism remains unclear. Methods In the present study, we employed machine …

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FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai et autres

Small extracellular vesicles (sEVs) contain abundant circular RNAs (circRNAs) and are involved in cellular processes, particularly hypoxia. However, the process that packaging of circRNAs into neuronal sEVs under hypoxia is unclear. This study revealed the spatial mechanism of the Fused in Sarcoma …

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