Sascha Heinemann

Preclinical evaluation of patient-specific 3D-printed PDLLA/SrHAp implants in a minipig segmental mandibular defect model

Christian Bräuer, Elisabeth Jarmer, Anja Lode, Tatjana Fecht et autres

Large segmental mandibular defects remain difficult to reconstruct, and patient-specific biodegradable scaffolds produced by additive manufacturing may offer an alternative to permanent alloplastic implants. This exploratory study evaluated three 3D-printed poly(DL-lactide) (PDLLA)-based implant configurations in a periosteum-preserving minipig mandibular defect model: PDLLA, …

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Biphasic Bone Implants through Hybrid Extrusion Printing of Thermoplastic Poly(lactic- co -glycolic) acid and Strontium-Modified Calcium Phosphate Bone Cement

Max von Witzleben, Tilman Ahlfeld, Richard Frank Richter, Anna-Maria Placht et autres

-glycolide) (PLLA-PGA) were successfully fabricated using an optimized extrusion-based 3D printing and postprocessing protocol. Degradation studies in water showed that the presence of the SrCPC phase in the biphasic scaffolds buffered the acidic degradation products of PLLA-PGA, delaying and attenuating the pH …

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Evaluation of maximum overhang angles for the support-free additive manufacturing of calcium phosphate cement structures

Martin Pendzik, Salman Al Dheim, Philipp Sembdner, Stefan Holtzhausen et autres

Abstract The paper examines the process parameters of 3D printing for the manufacturing of implant structures made of calcium phosphate cement, taking into account different overhang angles. The aim of the investigation is to ensure a dimensionally stable manufacturing of overhangs that …

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Clinically applicable antibiotic modification of ready-to-use calcium phosphate cement pastes

Alicia Zeiner, Sandra Hinderer, Andreas Hoess, Sascha Heinemann et autres

BACKGROUND: Ready-to-use non-aqueous cement pastes consist of an organic, water-miscible liquid phase in which cement powder is dispersed. While the modification of classical aqueous powder/liquid cement pastes with antibiotics has been extensively investigated, only a few studies previously published aimed at drug …

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Application of 3D printed calcium phosphate cement scaffolds in open wedge high tibial osteotomy (owHTO) – A retrospective clinical evaluation

Richard Frank Richter, Frank Pries, Volker Alt, Anja Lode et autres

Calcium phosphate cements (CPC) are widely used materials for filling bone defects and bone augmentation. Developments in CPC formulations have led to a practically unlimited processability, allowing to use these formulations for new fabrication methods like extrusion-based 3D-printing. This study shows the …

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Investigation of the Adhesion Behavior of Calcium Phosphate Cement Depending on Geometric Parameters

Martin Pendzik, Bassem Moughnieh, Philipp Sembdner, Stefan Holtzhausen et autres

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Poly(dl-lactide) Polymer Blended with Mineral Phases for Extrusion 3D Printing—Studies on Degradation and Biocompatibility

Corina Vater, Christian Bräuer, Stefanie Grom, Tatjana Fecht et autres

A promising therapeutic option for the treatment of critical-size mandibular defects is the implantation of biodegradable, porous structures that are produced patient-specifically by using additive manufacturing techniques. In this work, degradable poly(DL-lactide) polymer (PDLLA) was blended with different mineral phases with the …

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Antioxidant flavonoid-loaded nano-bioactive glass bone paste: in vitro apatite formation and flow behavior

Mehri Sohrabi, Saeed Hesaraki, Mostafa Shahrezaee, Alireza Shams-Khorasani et autres

bioactivity of the quercetin-loaded pastes. The washout resistance was found to be more than 96% after 14 days of immersion in simulated body fluid (SBF) as well as tris-buffered and citric acid-buffered solutions at 25 °C and 37 °C. All pastes exhibited …

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FURTHER DEVELOPMENT OF THE DESIGN PROCESS FOR HYBRID INDIVIDUAL IMPLANTS

Martin Pendzik, Stefan Holtzhausen, Sascha Heinemann, Kristin Paetzold

Abstract Additive manufacturing (AF) is characterised by a high degree of individuality and flexibility with regard to design and product layout. This enables the integration of different functions in a component. Due to these properties, AM has established itself in medical technology …

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Three-Dimensional Plotted Calcium Phosphate Scaffolds for Bone Defect Augmentation—A New Method for Regeneration

Matthias Christian Schulz, Stefan Holtzhausen, Berthold A. Nies, Sascha Heinemann et autres

For sinus grafting, different methods and materials are available. One possible shortcoming of particulate bone grafts is either overfilling or augmenting the planned implant area insufficiently. To overcome this risk and to determine the implant position prior augmentation, we present an approach …

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A comparative analysis of 3D printed scaffolds consisting of poly(lactic- co -glycolic) acid and different bioactive mineral fillers: aspects of degradation and cytocompatibility

Tilman Ahlfeld, Anja Lode, Anna-Maria Placht, Tatjana Fecht et autres

. Cell culture experiments with the human osteosarcoma cell line SAOS-2 and human dental pulp stem cells (hDPSC) indicated the high cytocompatibility of the composites: For all material groups cell spreading and complete colonization of the scaffolds over the culture period of …

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Confirmation of Calcium Phosphate Cement Biodegradation after Jawbone Augmentation around Dental Implants Using Three-Dimensional Visualization and Segmentation Software

Qusai Alkhasawnah, Sera Elmas, Keywan Sohrabi, Sameh Gabr Attia et autres

The use of autologous bone graft for oral rehabilitation of bone atrophy is considered the gold standard. However, the available grafts do not allow a fast loading of dental implants, as they require a long healing time before full functionality. Innovative bioactive …

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