Ikuya Tsuge

Decreased Basophil Activation against House Dust Mite after Japanese Cedar Pollen Subcutaneous Immunotherapy: A Retrospective Study

Chisato Inuo, Hitoshi Ando, Kenichi Tanaka, Yoichi Nakajima et autres

BACKGROUND: Allergen-specific immunotherapy (AIT), an established treatment for allergic diseases, prevents the development of other allergic manifestations. Although the mechanisms remain unclear, AIT has been shown to reduce basophil activation (BA) against nontarget allergens. OBJECTIVES: The aim of this study was to …

jp (code pays fourni par la source)

Breakpoints in complex chromosomal rearrangements correspond to transposase-accessible regions of DNA from mature sperm

Takeshi Sugimoto, Hidehito Inagaki, Tasuku Mariya, Rie Kawamura et autres

Constitutional complex chromosomal rearrangements (CCRs) are rare cytogenetic aberrations arising in the germline via an unknown mechanism. Here we analyzed the breakpoint junctions of microscopically three-way or more complex translocations using comprehensive genomic and epigenomic analyses. All of these translocation junctions showed …

jp (code pays fourni par la source)

TREC/KREC Newborn Screening followed by Next-Generation Sequencing for Severe Combined Immunodeficiency in Japan

Manabu Wakamatsu, Daiei Kojima, Hideki Muramatsu, Yusuke Okuno et autres

jp (code pays fourni par la source)

Evaluation of oral immunotherapy efficacy and safety by maintenance dose dependency: A multicenter randomized study

Kiyotake Ogura, Noriyuki Yanagida, Sakura Sato, Takanori Imai et autres

BACKGROUND: Generally, oral immunotherapy (OIT) aims for daily administration. Recently, the efficacy of treatment with OIT at a low dose has been reported. However, the optimal dose and the evaluation of dose-dependent OIT outcome have not been described. METHODS: A multicenter, parallel, …

jp (code pays fourni par la source)

Changes in passively‐sensitized basophil activation to αS1‐casein after oral immunotherapy

Teruaki Matsui, Michihiro Naito, Kazunori Tagami, Iwao Tajima et autres

Abstract Introduction Immune response to cow's milk allergen (CMA) has been analyzed mostly using crude milk antigen or a mixture of various caseins. This study aimed to assess the changes in the immunological response against αS1‐casein during oral immunotherapy (OIT) and to …

ir, jp (code pays fourni par la source)

Changes in the characteristics of patients with latex allergy from 1999 to 2014.

Manabu Kawai, Yasuto Kondo, Yoichi Nakajima, Ikuya Tsuge et autres

OBJECTIVES: We conducted a multicenter study using the same questionnaire in 1999 and 2014 to investigate changes in the characteristics of patients with latex allergy. METHODS: We mailed questionnaires on latex allergy to hospitals in Japan that were members of the Japanese …

jp (code pays fourni par la source)

Utility of Newborn Screening for Severe Combined Immunodeficiency and X-Linked Agammaglobulinemia Using TREC and KREC Assays

Manabu Wakamatsu, Hideki Muramatsu, Shinsuke Kataoka, Yusuke Okuno et autres

Background Severe combined immune deficiency (SCID) is a potentially fatal primary immunodeficiency due to the absence of T and B lymphocyte function. Early intervention for patients with SCID results in a higher survival rate. From 2017, we launched the first optional newborn …

jp (code pays fourni par la source)

Identification of autoantibodies using human proteome microarrays in patients with IPEX syndrome

Akihiro Hoshino, Hirokazu Kanegane, Masanori Nishi, Ikuya Tsuge et autres

jp (code pays fourni par la source)

Tolerability of partially and extensively hydrolysed milk formulas in children with cow's milk allergy.

Chisato Inuo, Kenichi Tanaka, Yoichi Nakajima, Kazuo Yamawaki et autres

BACKGROUND AND OBJECTIVES: The safety and tolerability of hydrolysed cow's milk protein-based formulas, particularly partially hydrolysed formulas (pHFs), in children with cow's milk allergy (CMA) remain poorly understood. We evaluated the tolerability of hydrolysed cow's milk-based formulas in children with CMA. METHODS …

jp (code pays fourni par la source)

Combination of TREC Measurement and Next-Generation Sequencing in Newborn Screening for Severe Combined Immunodeficiency: A Pilot Program in Japan

Hideki Muramatsu, Daiei Kojima, Yusuke Okuno, Shinsuke Kataoka et autres

Abstract INTRODUCTION Severe combined immunodeficiency disease (SCID) is the most severe form of primary immunodeficiency disorders (PIDs). Impaired cellular and humoral immunity renders the affected infants susceptible to various infections and results in death within the first 2 years of life. Affected …

jp (code pays fourni par la source)

Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran

Rie Satoh, Ikuya Tsuge, Reiko Tokuda, Reiko Teshima

jp (code pays fourni par la source)

Anaphylaxis to xylitol diagnosed by skin prick test and basophil activation test

Okamoto Kaoru, Michiko Kagami, Manabu Kawai, Yuji Mori et autres

Fig. 1.Basophil Activation Test using the patients' blood sample.

jp (code pays fourni par la source)