Xiao‐Fan Wang

Single-Cell Mendelian Randomization Identifies Cell-Type Specific Genetic Drivers of Lung Cancer Subtypes

Chengsong Yan, Xiao‐Fan Wang

Abstract Background Genome-wide association studies (GWAS) have identified many loci linked to lung cancer, but connecting these loci to causal genes and relevant cell types remains difficult. Traditional Mendelian randomization (MR) using bulk tissue eQTLs averages signals across diverse cells, masking cell-specific …

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L-Glutamate enables the EGFR-MEK-ERK-mTFB2 axis to enhance mitochondrial biogenesis in intestinal stem cells

Cai-xia Dou, Hongbo Qu, Ying‐chao Qin, Xiao‐Fan Wang et autres

Intestinal stem cells (ISCs) sustain epithelial homeostasis through rapid mitochondrial metabolism, however, how they sense nutrient signals to regulate mitochondrial function remains unclear. We examined the role of L-glutamate (Glu) in regulating cell mitochondrial biosynthesis using in vivo piglets, ex vivo porcine …

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Stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress

Crystal Young, Xiaohan Zhang, Xiao‐Fan Wang, Aaron P. Kellogg et autres

It is now recognized that patient and animal models expressing genetically encoded misfolded mutant thyroglobulin (TG, the protein precursor for thyroid hormone synthesis) exhibit dramatic swelling of the endoplasmic reticulum (ER), with ER stress and cell death in thyrocytes - seen both …

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Single-cell and spatial detection of senescent cells using DeepScence

Yilong Qu, Bing Ji, Runze Dong, Liangcai Gu et autres

Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence is based on CoreScence, a senescence-associated gene set …

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Identification of volatile and non-volatile components of two lemons based on sensory characteristics, electronic sensing evaluation and untargeted metabolomics

B. He, Long Wan, Zhenyu Ni, Luqi Yin et autres

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TSC2/mTORC1 integrates deoxynivalenol signals recognized by membrane receptors IR and EGFR to restrict intestinal stem cell function

Cai-xia Dou, Hongbo Qu, Ying‐chao Qin, Xiao‐Fan Wang et autres

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Iturin A Potentiates Differentiation of Intestinal Epithelial Defense Cells by Modulating Keap1/Nrf2 Signaling to Mitigate Oxidative Damage Induced by Heat-Stable Enterotoxin B

Geng-xiu Zan, Hong Qu, Xinyang Li, Qiliang Peng et autres

Intestinal stem cells (ISCs) maintain epithelial renewal through their proliferation and differentiation capabilities, responding to various intestinal insults. However, the impact of iturin A, a natural antimicrobial peptide, on ISC viability and its potential to mitigate heat-stable enterotoxin b (STb)-induced intestinal damage …

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Amyloid-β precursor protein promotes tumor growth by establishing an immune-exclusive tumor microenvironment

Tao Yin, Guoping Wang, Zhehao Ma, Liuyang Wang et autres

Abstract During initiation and progression, cancerous tissue hijacks a series of elaborate tissue homeostatic mechanisms to avoid immune surveillance, including neuro-immune interactions. Here, we show that amyloid-β precursor protein (APP) and its β-cleavage product amyloid-β1-42 (Aβ1-42), well-known in the pathogenesis of Alzheimer’s …

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Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity

Shicheng Lin, Dianna Liu, Tianyu Liang, Xiao‐Fan Wang et autres

BACKGROUND: Cryoablation plays a key role in the comprehensive management of lung adenocarcinoma, characterized by its ability to activate antitumor immunity. This study aimed to explore the impact of cryoablation on the local immune microenvironment, focusing on regulatory T cells (Tregs) and …

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Neoadjuvant anti-4-1BB confers protection against spontaneous metastasis through low-affinity intratumor CD8 + T cells in triple-negative breast cancer

Bryan Jian Wei Lim, Mingyong Liu, Liuyang Wang, Sharleen Li Ying Kong et autres

ABSTRACT Neoadjuvant immunotherapy seeks to harness the primary tumor as a source of relevant tumor antigens to enhance systemic anti-tumor immunity through improved immunological surveillance. Despite having revolutionized the treatment of patients with high-risk early-stage triple-negative breast cancer (TNBC), a significant portion …

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Q-Learning Based Detector Design for State Estimation Under Non-gaussian Noises

Yue Luo, Yun Liu, Wen Dong Yang, Xiao‐Fan Wang

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A Semi-supervised Protein Complex Identification Algorithm Based on Sparseness Constraint

Guang‐Ming Liu, Fengqing Dang, Bin Wang, Yonghong Peng et autres

Abstract Recognising protein complexes in protein interaction networks is crucial, but poses a major challenge due to the frequency of noisy interactions. These networks typically involve numerous protein complexes, with each protein generally only participating in a few complexes. Current recognition models …

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