Bryan Jian Wei Lim

Amyloid-β precursor protein promotes tumor growth by establishing an immune-exclusive tumor microenvironment

Tao Yin, Guoping Wang, Zhehao Ma, Liuyang Wang et autres

Abstract During initiation and progression, cancerous tissue hijacks a series of elaborate tissue homeostatic mechanisms to avoid immune surveillance, including neuro-immune interactions. Here, we show that amyloid-β precursor protein (APP) and its β-cleavage product amyloid-β1-42 (Aβ1-42), well-known in the pathogenesis of Alzheimer’s …

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Neoadjuvant anti-4-1BB confers protection against spontaneous metastasis through low-affinity intratumor CD8 + T cells in triple-negative breast cancer

Bryan Jian Wei Lim, Mingyong Liu, Liuyang Wang, Sharleen Li Ying Kong et autres

ABSTRACT Neoadjuvant immunotherapy seeks to harness the primary tumor as a source of relevant tumor antigens to enhance systemic anti-tumor immunity through improved immunological surveillance. Despite having revolutionized the treatment of patients with high-risk early-stage triple-negative breast cancer (TNBC), a significant portion …

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Narrative-Based Interactive Learning for Scam Prevention: Rich Within Reach

Wenxin Tu, Bryan Jian Wei Lim, Victor Yeok Kein Ong, Jicong Tan et autres

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Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response

Lianmei Tan, Tao Yin, Handan Xiang, Liuyang Wang et autres

Immunotherapy successfully complements traditional cancer treatment. However, primary and acquired resistance might limit efficacy. Reduced antigen presentation by MHC-I has been identified as potential resistance factor. Here we show that the epigenetic regulator ubiquitin-like with PHD and ring finger domains 1 (UHRF1), …

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Breaking NGF–TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection

Tao Yin, Guoping Wang, Liuyang Wang, Poorva Mudgal et autres

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Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

Christopher C. Pan, Raquel Maeso‐Díaz, Tylor R. Lewis, Kun Xiang et autres

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Abstract 5083: Investigating the development and therapeutic potential of intra-tumoral CXCR6+ effector/effector memory T cells (TEFF/EM) in triple-negative breast cancer

Bryan Jian Wei Lim, Xiao‐Fan Wang, Qi-Jing Li

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype that makes up 10-20% of all breast cancer cases. Because of the higher risk of metastasis and recurrence post-treatment, there is a need to develop novel therapeutics to address these challenges. In previously …

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A systematic analysis of microtubule-destabilizing factors during dendrite pruning in Drosophila

Shufeng Bu, Wei Lin Yong, Bryan Jian Wei Lim, Shu Kondo et autres

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Resident memory T cells in tumor-distant tissues fortify against metastasis formation

Laura S. Christian, Liuyang Wang, Bryan Jian Wei Lim, Dachuan Deng et autres

As a critical machinery for rapid pathogen removal, resident memory T cells (T RM s) are locally generated after the initial encounter. However, their development accompanying tumorigenesis remains elusive. Using a murine breast cancer model, we show that T RM s develop …

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Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formation

Joanne Wei Kay Ku, Yahua Chen, Bryan Jian Wei Lim, Stephan A. Gasser et autres

is the causative agent of melioidosis, an infectious disease in the tropics and subtropics with high morbidity and mortality. The facultative intracellular bacterium induces host cell fusion through its type VI secretion system 5 (T6SS5) as an important part of its pathogenesis …

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Resident Memory T Cells in Tumor-Distant Tissues Fortify Against Metastasis Formation

Laura S. Christian, liuyang wang, Haiyang Wu, Dachuan Deng et autres

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Abstract 897: Lipid metabolism is involved in mitotic slippage-induced SASP upon treatment with anti-mitotic drugs

Karen Crasta, Alex Xing Fah Wong, Bryan Jian Wei Lim

Abstract Aberrant lipid accumulation is a hallmark of cancer. However, there is little known regarding mechanisms linking lipid metabolism to chemotherapy-induced cell fates. Here, we describe lipid accumulation in cells following antimitotic drug-treatment. Cells arrested in mitosis, as well as cells that …

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