Haiya Wu

1699-P: Effect of Bofanglutide on the Pharmacokinetics of Metformin in Healthy Participants

JIN WANG, JING ZHAO, LIYUAN ZHAO, TIAN XIE et autres

Introduction and Objective: Bofanglutide is a bi-weekly GLP-1 analog under development for treatment of type 2 diabetes and overweight or obesity. Given the common co-administration of metformin with GLP-1 analogs, it is critical to evaluate the potential pharmacokinetic (PK) interaction between bofanglutide …

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807-P: Comparable Glycemic Control of Once-Weekly Insulin GZR4 Relative to Once-Daily Insulin Degludec in Insulin-Naïve Chinese Subjects with T2D

Liming Chen, XIAOLIN DONG, Huihui Wang, Zhifeng Cheng et autres

Introduction and Objective: Once-weekly (QW) insulin aims to reduce treatment burden by lowering injection frequency, potentially enhancing treatment acceptance and adherence. This trial evaluated the efficacy and safety of a novel QW insulin analog GZR4 versus once-daily (QD) insulin degludec (IDeg) in …

808-P: Superior Glycemic Control Achieved with Once-Weekly Insulin GZR4 Compared with Once-Daily Insulin Degludec in Insulin-Treated Chinese Subjects with T2D

Liming Chen, XIAOLIN DONG, Huihui Wang, Zhifeng Cheng et autres

Introduction and Objective: Once-weekly (QW) insulins have emerged as a research focus due to their potential to enhance treatment acceptance and adherence by reducing injection frequency. This trial studied the efficacy and safety of a novel QW insulin analog GZR4 versus once-daily …

769-P: Bofanglutide (GZR18), a Novel GLP-1RA, Improved Glycemic Control and Cardiometabolic Risk Factors in Chinese Patients with T2D

W. Li, MING LIU, RUIHUA DONG, Jing Zhao et autres

Introduction and Objective: This randomized, double-blind, placebo-controlled, dose-escalation phase 2a trial aimed to assess the safety and efficacy of a novel GLP-1 RA, bofanglutide (GZR18), in Chinese adults with T2D. Methods: Thirty-six adults with T2D inadequately controlled with lifestyle management and/or non-compliance …

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752-P: Efficacy and Safety of Bofanglutide (GZR18), a Biweekly GLP-1RA, Compared with Semaglutide in Chinese Patients with T2D

Haiya Wu, MING LIU, Zhifeng Cheng, Lu Li et autres

Introduction and Objective: Efforts have focused on developing GLP-1 RAs with less frequent dosing to improve patient acceptance and adherence in managing T2D. This randomized, open-label, phase 2b trial aimed to evaluate the efficacy and safety of a novel bi-weekly (Q2W) GLP-1 …

1424-P: Generalizability of Glucagon-Like Peptide-1 Receptor Agonist Cardiovascular Outcome Trials to the Type 2 Diabetes Population in China

Xiaoling Cai, Lin Zhang, Haiya Wu, Li Kun Huo et autres

Introduction: A number of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been evaluated in cardiovascular outcome trials (CVOTs). In this study, we aim to examine the generalizability of results from GLP-1 RAs CVOTs among Chinese type 2 diabetes (T2D) population. Methods: Patients …

Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a meta‐analysis

Wenjia Yang, Xiaoling Cai, Haiya Wu, Linong Ji

Abstract Background Metformin is first‐line therapy for patients with diabetes. However, it may lower vitamin B12 concentrations, which could have hematological or neurological implications. This meta‐analyses reviewed all available studies on associations between metformin use and vitamin B12 levels, anemia, and neuropathy …

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Insulin adherence and persistence among Chinese patients with type 2 diabetes: a retrospective database analysis

Xiaoning He, Liming Chen, Ke Wang, Haiya Wu et autres

Objective: To assess adherence and persistence to insulin therapy and identify its associated factors among Chinese insulin-naïve patients with type 2 diabetes (T2D). Methods: Tianjin Urban Employee Basic Medical Insurance claims database was used (2008–2011). Adult patients with T2D who initiated insulin …

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Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands

Haiya Wu, K. Mezghenna, Patricia Mármol, Tingqing Guo et autres

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Neuroendocrine control of female reproductive function by the activin receptor ALK7

Tatiana Sandoval‐Guzmán, Christina Göngrich, Annalena Moliner, Tingqing Guo et autres

Activins are critical components of the signaling network that controls female reproduction. However, their roles in hypothalamus, and the specific functions of their different receptors, have not been elucidated. Here, we investigated the expression and function of the activin receptor ALK7 in …

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Impact of education level and individualized diabetic education on glucose control in diabetic patients

Jie Li, Jia–ping Tang, Haiya Wu, Jing Li et autres

Objective To observe the association between educational level and individualized diabetic education and glucose control in diabetic patients. Methods A total of 8887 sets of type 2 diabetic patients' information were collected from the diabetes information management system from January 2004 to …

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Fasting glucose level and acute insulin secretion stimulated by arginine

Junxi Lu, Weiping Jia, Yuqian Bao, Xiao–jing Ma et autres

Objective To explore the relationship between fasting plasma glucose (FPG) and acute insulin secretion stimulated by arginine. Methods A total of 626 adults [normal glucose tolerance (n=114), impaired glucose tolerance (n=60), and newly diagnosed type 2 diabetes mellitus (n=452)] were enrolled in …

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