Liming Chen

ChREBP ‐β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4

Ting Fang, Xinyu Yang, Xiaoqing Deng, Jingyi Wang et autres

Excessive fructose intake is strongly associated with metabolic diseases, with the carbohydrate response element-binding protein (ChREBP) playing a key role in its metabolism, particularly in renal tubules. However, the role of its active form, ChREBP-β, was previously unclear. In this study, ChREBP-β …

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Effects of age and disease duration on the glycaemic outcomes and safety of insulin glargine 300 U/ mL in people with type 2 diabetes in China: A post‐hoc analysis of the INITIATION study

Liming Chen, Qiu Zhang, Binhong Duan, Xiaohong Wu et autres

AIMS: To evaluate the glycaemic outcomes and safety of insulin glargine 300 U/mL (Gla-300) in Chinese people with uncontrolled type 2 diabetes (T2D) by baseline age and disease duration. MATERIALS AND METHODS: INITIATION was a 24-week, interventional, single-arm study where adults with …

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The Inflammation Effect in the Association Between Bilirubin and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Retrospective Cohort Study

Yanyan Chen, Shanshan Wang, Xiangna Chen, Bei Sun et autres

Background: The associations of bilirubin (BIL) and systemic inflammation with chronic kidney disease (CKD) remain unclear. This study examined associations among BIL, systemic inflammation, and CKD progression in type 2 diabetes patients, assessing systemic inflammation's mediating role. Methods: This retrospective cohort study …

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Integrated Aerobic Exercise and Multisensory Environment Training for Age-related Cognitive Decline via Hippocampal-prefrontal Neural Circuit Modulation

Huawei Lin, Yuxi Qiu, Zhongyi Hu, Liming Chen et autres

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Efficacy and safety of bi‐weekly cofrogliptin treatment replacing daily dipeptidyl peptidase‐4 inhibitors in Chinese patients with type 2 diabetes mellitus: A multicenter, open‐label, randomized controlled phase 2 trial

Congqing Pan, Hongwei Jiang, Yi Feng, Suijun Wang et autres

AIM: This study aimed to investigate the efficacy and safety of bi-weekly cofrogliptin treatment as a replacement for daily dipeptidyl peptidase-4 inhibitors (DPP-4is) in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This multicenter, open-label, randomized controlled study assigned participants in …

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Author response for "Efficacy and safety of bi-weekly cofrogliptin treatment replacing daily dipeptidyl peptidase-4 inhibitors in Chinese patients with type 2 diabetes mellitus: A multicenter, open-label, randomized controlled phase 2 trial"

Congqing Pan, Hongwei� Jiang, Yi Feng, Suijun Wang et autres

βeta-2 glycoprotein I is a novel regulator of Apolipoprotein E containing HDL particles in females

Ying Wang, Qi Miao, Liming Chen, Maaike Kockx et autres

BACKGROUND: βeta-2 glycoprotein I (β2GPI, Apolipoprotein H) is a plasma glycoprotein best known as a major autoantigen in autoimmune disorders such as antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE), both of which confer elevated cardiovascular risk. Despite its prominence in autoimmunity, …

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Reduced Primary Teeth Fluorosis In Guizhou’s Endemic Areas

Jiangling Sun, Wei Yang, Liming Chen, Jilin Wu et autres

This study investigated the prevalence of primary teeth fluorosis among children aged 6–8 years in endemic fluorosis areas of Guizhou, China, over 12 years (2008–2020), aiming to evaluate the impact of public health interventions. Cluster random sampling selected four elementary schools in …

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Alterations And Occurrence Of Fluorine In Moderate Dental Fluorosis Enamel

Liming Chen, Ye Tang

To study the alterations and existence of fluorine in fluorosis enamel compared to that of the normal teeth. Electron probe microanalysis (EPMA) was used to analyze the content of fluorine in enamel of the both teeth. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) …

Guidelines on primary healthcare for type 2 diabetes in China, 2025

WEIPING JIA, Dalong Zhu, Lixin Guo, Liming Chen et autres

In recent years, the prevalence of diabetes in China has increased significantly, and approximately 11.9% of Chinese adults had diabetes in 2020. Moreover, there are several rigorous challenges in diabetes prevention and glycaemic control, especially at the primary medical care level. In …

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Implementation of Established Global Guidelines in the Management of CKD in Patients with Type 2 Diabetes in Asia

Rajiv Agarwal, Masaomi Nangaku, Liming Chen, Angela Yee‐Moon Wang et autres

Worldwide, CKD is seen in one in nine adults; type 2 diabetes (T2D) is the most common cause. The population of just two countries in Asia, India and China, constitutes about 35% of the global population and is larger than the population …

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Effective of high-intensity interval training and moderate-intensity continuous training on body composition, glycolipid metabolism, and cardiopulmonary function in patients with pre-diabetes: a randomized controlled trial

Xinbei Chen, Lijuan Wu, Yan Zheng, Xuling Ni et autres

Aims The aim of this study is to compare the effectiveness of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on body composition, cardiovascular function, glycolipid metabolism, and cardiopulmonary function in patients with pre-diabetes. Methods Seventy-one participants were randomly assigned to …

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