Yuanzhi Xu

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang et autres

Craniofacial bone defects remain a significant clinical challenge due to the complex healing process among immune regulation, vascularization, and osteogenesis. Asiatic acid (AA), a natural pentacyclic triterpenoid, has shown promise in modulating inflammation and promoting bone repair, yet its clinical application is …

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Catechin promotes osteogenic differentiation via AMPK-mediated autophagy activation in bone marrow mesenchymal stem cells

Haixia Liu, Jing Yue, Zhen Guo, Nian Zhou et autres

BACKGROUND: Catechin (CH) exhibits protective effects on bone metabolism, but its underlying mechanism remains incompletely understood. METHODS: We investigated the osteogenic effects of CH and its molecular pathways using bone marrow mesenchymal stem cells and MC-3T3-E1 preosteoblasts. Cell viability was assessed after …

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Bone marrow mesenchymal stem cell-derived exosomes alleviate neuropathic pain after spinal cord injury by inhibiting the TLR4/MyD88/NF-κB pathway

Yuanzhi Xu, Shaoshuai Wang, Zefu Li, Junmin Wang et autres

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Neoclassical impurities transport induced by 3D fields

Hui Sheng, Youwen Sun, W. M. Zhang, Cheng Ye et autres

The neoclassical impurities transport induced by 3D fields, known as the neoclassical toroidal viscosity (NTV) flux, is discussed in detail using NTVTOK. A substantial inward NTV flux of impurities is observed, which plays a key role in impurity transport and provides a …

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Preparation of agarose microspheres with large pore size and high load and purification of antibody in serum based on microfluidic technology

Guanglei Chang, Miaomiao Yang, Zhaobin Xu, Xinling Wang et autres

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Leonurine Promotes the Osteoblast Differentiation of Rat BMSCs by Activation of Autophagy via the PI3K/Akt/mTOR Pathway

Bingkun Zhao, Qian Peng, Enoch Hin Lok Poon, Fubo Chen et autres

BACKGROUND: , has been shown to exhibit anti-inflammatory and antioxidant effects. The aim of this study was to investigate the effect of leonurine on bone marrow-derived mesenchymal stem cells (BMSCs) as a therapeutic approach for treating osteoporosis. MATERIALS AND METHODS: Rat bone …

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Knockout of NRAGE promotes autophagy‐related gene expression and the periodontitis process in mice

Haixia Liu, Xu Zhang, Qixiang Yang, Xueqin Zhu et autres

BACKGROUND AND OBJECTIVE: Neurotrophin receptor-interacting MAGE homologue (NRAGE) plays a crucial role in the regulation of bone metabolism. The present study investigated the regulation role of NRAGE on autophagy activation and periodontitis process during experimental periodontitis. MATERIALS AND METHODS: Six-week-old wild-type (WT) …

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Umbilical cord-derived mesenchymal stem cells efficiently induced apoptosis of endometrial carcinoma cells

Jie Zheng, Pei Liu, Chunxia Li, Liting Cheng et autres

Cellular Internalization–Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein‐Mediated Protection of Stem Cells

Shengcai Qi, Pengfei Zhang, Ming Ma, Minghua Yao et autres

Nanotechnology employs multifunctional engineered materials in the nanoscale range that provides many opportunities for translational stem cell research and therapy. Here, a cell-penetrating peptide (virus-1 transactivator of transcription)-conjugated, porous silicon nanoparticle (TPSi NP) loaded with the Wnt3a protein to increase both the …

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Mesoporous Silica Nanoparticles‐Reinforced Hydrogel Scaffold together with Pinacidil Loading to Improve Stem Cell Adhesion

Ning Wang, Ming Ma, Yu Luo, Tianzhi Liu et autres

Abstract Although hydrogels can be applied in mimicking the native extracellular matrix environment, they generally suffer from weak mechanical properties, as well as the lack of a sustained supply of nutrients or simulants to maintain cell functions, which severely limits their further …

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Knockdown of NRAGE induces odontogenic differentiation by activating NF-κB signaling in mouse odontoblast-like cells

Qi Wu, Jing Li, Pingping Song, Yuanzhi Xu et autres

PURPOSE: Neurotrophin receptor-interacting MAGE homologue (Nrage) plays an important role in bone development and the metabolism of normal skeletal structures. Our previous study showed that Nrage inhibited the odontogenic differentiation of mouse dental pulp cells. However, the potential roles and mechanism of …

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Effects of neurotrophin receptor‐mediated MAGE homology on proliferation and odontoblastic differentiation of mouse dental pulp cells

Shengcai Qi, Qi Wu, Ji Ma, Jie Li et autres

OBJECTIVES: This study aimed to investigate effects of neurotrophin receptor-mediated melanoma antigen-encoding gene homology (NRAGE) on proliferation and odontoblastic differentiation of mouse dental pulp cells (mDPCs). MATERIALS AND METHODS: Mouse dental pulp cells were infected with recombinant lentivirus to stably knockdown expression …

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