Shengcai Qi

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Kai-Run Zhang, Tianbao Zhu, Anqi Liu, J. Deng et autres

ABSTRACT Cognitive impairment is a growing global health challenge, yet its multifactorial drivers remain incompletely understood. Intermittent hypoxia (IH) and periodontitis are identified as significant independent risk factors that frequently co‐occur. This study investigates the mechanisms through which these conditions accelerate cognitive …

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Porphyromonas gingivalis Promotes Neuroinflammation by Microglial Ferroptosis via NOX4/PPAR-α/PGC-1α Pathway

Xue Li, Zhenhuan Wu, Chao Yao, Pengye Zhang et autres

Background: Emerging evidence links Porphyromonas gingivalis ( P.g ), a keystone oral pathogen, neuroinflammation as a driver of Alzheimer’s symptoms. This study aimed to investigate the molecular mechanism by which P.g triggers neuroinflammation and cognitive decline. Methods: Wild-type (WT) mice were orally …

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An ultrathin gas-permeable imperceptible electronic skin enables maxillofacial electrophysiological monitoring

Yaqi Zhang, Minfeng Wu, Yile Wang, Xiang Chen et autres

, gum chewing and intermittent occlusion). In particular, ultrathin dimensionality substantially diminishes foreign body perceptibility and associated wearer discomfort, thereby elevating sustained comfort thresholds and long-term therapeutic viability. This work presents a novel material-device strategy for next-generation wearable bioelectric sensing platforms, enabling …

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Micro-Arc Oxidized Titanium-Cerium Alloy Enhances Osseointegration Under Osteoporosis

Yuan Hong Gao, Yaqi Zhang, Li Bo Sun, Shengcai Qi

To address the issue of poor bone-implant combination ratio (BIC%) among osteoporotic patients, this study aimed to develop a micro-arc oxidized titanium-cerium alloy and investigate its regulatory effects on bone marrow mesenchymal stem cells (BMSCs) and mitochondrial function under oxidative stress conditions. …

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Rhein-Integrated Extracellular Matrix-Mimetic Hydrogel for Accelerated Healing of Infected Wounds within 7 Days

Liuyan Tang, Jinwei Cao, Ningning Li, Hao Yu et autres

Treating chronic wounds remains a significant challenge due to persistent bacterial infections, prolonged inflammation, and inadequate mechanical adaptability, all of which severely impede tissue repair. Despite significant advancements in wound care, existing wound dressings struggle to rapidly heal infected wounds due to …

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Capsaicin-activated autophagy protects BMSC function under oxidative stress: mechanisms and therapeutic implications

Yurong Chen, Qian Peng, Dongmei Lan, Chao Hua Yao et autres

Bone marrow stromal cells (BMSCs) play an important role in bone regeneration, but their functional activity is affected by oxidative stress, which is a key pathological feature of osteoporosis. The aim of this study was to investigate the effects of capsaicin on …

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Biodegradable piezoelectric nanofibers with MXene-enhanced self-polarization for ultrasound-accelerated bone regeneration

Yaqi Zhang, Tianlong Wang, Yurong Chen, Qingyu Zhu et autres

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Dually tissue-anchoring platelets backpacking MDSC-derived extracellular vesicles to locally sustain immune reprogramming for inflammation resolution

Shuang Li, Tinglei Huang, Xue Li, Shengcai Qi et autres

Diverse immuno-inflammatory disorders are typically caused by dysregulated immunoactivation and the consequently chronic tissue inflammation. However, current therapeutics have exhibited mixed success due to either inherent inefficacy or limited localized tissue retention. Holistic approaches capable of integrating multipotent biotherapeutics with their optimized …

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Enhanced biological performance of Sr2+-doped nanorods on titanium implants by surface thermal-chemical treatment

Xinrui Dai, Jianghui Zhao, Shengcai Qi, Ping Liu et autres

Abstract Titanium alloys, as artificial implants for orthopedic diseases, are prone to aseptic loosening and infection after surgery because their smooth surface restricts the attachment and movement of osteoblasts, resulting in a lack of osteogenic and antimicrobial properties. This study aimed to …

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Predictive value of albumin-corrected anion gap for acute kidney injury risk assessment in sepsis: Insights from MIMIC-IV

Jing Nie, Shengcai Qi

Acute kidney injury (AKI) represents a major cause of death among patients with sepsis. While recent evidence suggests that albumin-corrected anion gap (ACAG) might serve as an early indicator of AKI, its prognostic capabilities require further investigation. We conducted a retrospective analysis …

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An Artificial Piezoelectric-Conductive Integrated Peri-Implant Gingiva Enables Efficient Bacterial Inhibition and Soft-Tissue Integration

Han Wen, Zhiqing Liu, Hao Yu, Yaqi Zhang et autres

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Analysis of PM2.5 Morphology, Composition and Health Risk in a Multi‐Chair Dental Clinic

Fengqin Tang, Shengcai Qi, Xiaoshan Tang, Xueyun Wen et autres

ABSTRACT Particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) at high concentrations in dental clinics poses significant health risks to healthcare professionals. However, the morphology and chemical composition of PM2.5 in specific environments are not yet fully elucidated. In this study, …

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