Haixia Liu

Catechin promotes osteogenic differentiation via AMPK-mediated autophagy activation in bone marrow mesenchymal stem cells

Haixia Liu, Jing Yue, Zhen Guo, Nian Zhou et autres

BACKGROUND: Catechin (CH) exhibits protective effects on bone metabolism, but its underlying mechanism remains incompletely understood. METHODS: We investigated the osteogenic effects of CH and its molecular pathways using bone marrow mesenchymal stem cells and MC-3T3-E1 preosteoblasts. Cell viability was assessed after …

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cGAS-STING signaling in the tumor microenvironment induces myeloid cell activation and favors T cell-mediated antitumor immunity

Meiji Ren, Zhichao Ai, Yan Zhang, Linghong Shi et autres

The cancer-immunity cycle is regulated by a series of stimulatory and inhibitory factors. The stimulator of interferon genes (STING) pathway, a key stimulator of type I interferon production, connects innate and adaptive immunity to promote antitumor responses. Using a syngeneic pancreatic tumor …

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Carvacrol-mediated protection against Aeromonas veronii-induced intestinal injury in Micropterus salmoides via gut microbiota regulation and immune modulation

Xiaoyu Qi, Xiaonan Sun, Hongzhou Xu, Tian Yang et autres

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Gut Microbiota Dysbiosis and LPS/NLRP3/GSDMD Pyroptosis Drive Hepatic Fibrosis: Therapeutic Potential of a Synbiotic Intervention

Yuxin Che, Yanyan Xu, Haixia Liu, Jiaojiao Yang et autres

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Enhancing cellulase biosynthesis of Bacillus subtilis Z2 by regulating intracellular NADH level

Shuai Liu, Yi Li, Lin Quan, Haixia Liu et autres

Optimizing cellulase biosynthesis in Bacillus subtilis is crucial for enhancing enzymatic yield in lignocellulosic biomass conversion. However, the regulatory mechanisms linking intracellular NAD(H/ + ) levels to cellulase production remain elusive. In this study, we systematically screened 13 genes associated with NAD …

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Exploring the neurotoxic effects of cylindrospermopsin in early development of zebrafish: An integrated impact of oxidative stress, inflammatory response, and apoptosis

Xu Zhang, Jie Hu, Haixia Liu, Xuefei Zhou et autres

The increasing global spread of cyanobacteria and their toxin Cylindrospermopsin (CYN) is a growing concern.This study aimed to examine the toxic effects of CYN on the early neurodevelopment of zebrafish, and to identify the underlying mechanisms. The findings indicated that zebrafish exposed …

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Prevalence and genotyping of Enterocytozoon bieneusi in cattle from Shanxi and Inner Mongolia, China

Wenjun Fan, Shan Zhang, Lifeng Wang, Yulin Ding et autres

Enterocytozoon bieneusi is a zoonotic pathogen, with cattle serving as major reservoirs and important mediums for its transmission. However, data on the prevalence and subtypes of E. bieneusi in cattle from Northern Shanxi and Central Inner Mongolia, China, are limited. This study …

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Prevalence and Molecular Characterization of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in Donkeys of Inner Mongolia, Northern China

Li Zhao, Wenjun Fan, Chao Yi, Haixia Liu et autres

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Hemorrhage risk after coblation tonsillectomy in Chinese pediatric: a multicenter, prospective, observational cohort study

Hongming Xu, Shuyao Qiu, Jinxia Wang, Fugen Han et autres

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Autocrine/paracrine fibroblast growth factor 1 (FGF1) enhances systemic lipid metabolism in rainbow trout fed with a high-fat diet by elevating uridine levels through the AMPK signaling pathway and activating the upp2 promoter via irf1

Huixia Yu, Haolin Mo, Xiaoran An, Min‐Xia Yao et autres

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Case report: Two novel compound heterozygous variant of SLC12A3 gene in a gitelman syndrome family and literature review

Xiaochen Ji, Nan Zhao, Haixia Liu, Yutong Wu et autres

A 36-year-old unmarried male chef was incidentally diagnosed with hypokalemia during an evaluation for an acute perianal abscess. Despite potassium supplementation, he developed progressive weakness in his lower limbs, culminating in an inability to stand. Investigations confirmed severe hypokalemia, metabolic alkalosis, hypomagnesemia, …

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Central memory CD4+ T cells play a protective role against immune checkpoint inhibitor–associated myocarditis

Jiajun Yu, Bo Long, Ziyong Li, Xiaolong Tian et autres

AIMS: The widespread use of immune checkpoint inhibitors (ICIs) has demonstrated significant survival benefits for cancer patients and also carries the risk of immune-related adverse events. ICI-associated myocarditis is a rare and serious adverse event with a high mortality rate. Here, we …

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