Savita Yadav

MicroRNAs: Small molecules with big therapeutic potential

Hari Krishnan, Nirmal Chhikara, Anil Kumar Tomar, Savita Yadav

MicroRNAs (miRNAs) are small non-coding RNAs of approximately 20–25 nucleotides that regulate gene expression at transcriptional and post-transcriptional levels. They play critical roles in several cellular processes, including cell differentiation, proliferation, apoptosis, and immune regulation. Dysregulation of miRNAs has been associated with …

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Synthesis, in-Silico , drug-likeness studies, ADMET prediction and anticancer activity: novel 4-quinazolinyloxymethyl 3-aniline appended aryl amide derivatives

M. J. Mane, Savita Yadav, Youness Moukhliss, Hamid Maghat

Quinazoline has become a significant scaffold in pharmaceutical chemistry due to its unusual bioactivity and versatile biological profile. In this study, a library of 4-quinazolinyloxymethyl-3-aniline amide derivatives (6a−6k) and (7a−7k) was synthesized and characterized by FT-IR, ¹H-NMR, and LC-MS. The anticancer activity …

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Implicating Sperm microRNA hsa-miR-7977 and its Target Genes in Idiopathic Recurrent Pregnancy Loss: Evidence from Expression Analysis

Anil Kumar Tomar, Ayushi Thapliyal, Sarla Naglot, Soniya Dhiman et autres

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EVALUATING THE IMPLEMENTATION OF SECTION 89 CPC IN HARYANA’S CIVIL JUSTICE SYSTEM

A.K. Dixit, Dr. Teena Parmar, Savita Yadav

Section 89 of the Code of Civil Procedure, 1908 (CPC) represents a structural attempt to embed Alternative Dispute Resolution (ADR) within India’s formal civil justice process. Enacted to reduce judicial backlog and promote consensual settlement, the provision mandates courts to identify settlement …

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From Lipid Signaling to Cancer Therapy: the Expanding Role of Acylglycerol Kinase

Nivedita Vats, Shamima Akhtar, Savita Yadav

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Circulating SLC17A5 as a Diagnostic Biomarker of Early Endothelial Dysfunction in Young Dyslipidemic Individuals

Shamima Akhtar, Komal Sagar, Milind Padmakar Hote, Ambuj Roy et autres

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CCR5 ‐Mediated Reprogramming of Regulatory T Cells and Monocytic‐Myeloid‐Derived Suppressor Cells in Young Dyslipidemic Individuals: A Plausible Therapeutic Approach

Komal Sagar, Shamima Akhtar, Anil Kumar Tomar, Ambuj Roy et autres

ABSTRACT Chemokine receptor CCR5 is upregulated in the regulatory T cells (Tregs) and monocytic‐myeloid‐derived suppressor cells (M‐MDSCs) of young dyslipidemic individuals. In this study, we investigated the role of CCR5 in regulating the phenotypic and functional plasticity of Tregs and M‐MDSCs during …

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Decoding Shakespeare in the Indian context

Zainab Fatima, Madhurima Srivastava, Savita Yadav

Shakespeare's writings have found resonance in a variety of societies, spanning time, space, and culture. Shakespeare's plays have been adapted and reinterpreted in India, offering a rich field of study that reflects the dynamic interaction between his universal themes and India's unique …

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Development and Comparative Analysis of Probiotic-Enhanced Aceclofenac Tablets for Colon-Specific Delivery in Pharmaceuticals

Priyanka Dubey, Prinsi Sahpuriya, Savita Yadav, Ritu Deheriya et autres

In this research, we developed a novel approach to formulate colon-specific matrix tablets containing Aceclofenac. Employing the wet granulation method, we integrated guar gum as the polymeric matrix and harnessed the potential of probiotics as targeting aids. Our investigation revealed a remarkable …

Quantitative saliva proteomics of mild symptomatic COVID-19 patients during omicron surge Name(s) of the Author (s) with Affiliations & email i.d.:

Suneeta Suneeta, Anil Kumar Tomar, Savita Yadav, Nirupam Madan et autres

Background: The COVID-19 pandemic presented a challenge to biological researchers and clinicians involved in patient diagnosis and treatment due to an increase in SARS-COV-2 mutations. This demonstrated the necessity of a thorough molecular understanding of the disease to categorize various patient groups. …

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महसमनद जल क ककष 9 क वदयरथय क शकषक आककष पर परवरक वतवरण क परभव क अधययन

Savita Yadav, Lubhavani Tripathi

प्रस्तुत शोध-पत्र का उद्देश्य महासमुन्द जिले के कक्षा 9 के विद्यार्थियों की शैक्षिक आकांक्षा पर पारिवारिक वातावरण के सांख्यिकीय प्रभाव का परीक्षण करना है। अध्ययन के लिए उपलब्ध कराए गए 100 विद्यार्थियों के अभ्यास-आधारित आँकड़ों का उपयोग किया गया। नमूने में 50 …

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Sage and Rosemary Extract Gel: Anti-Aging Efficacy in D-galactose-Induced Skin Aging Model

Ashok Kumar Gupta, Reenu Yadav, Samisha Sharma, Jyotiram Arjun Sawale et autres

This study aimed to develop a topical herbal gel incorporating Salvia officinalis Linn and Rosmarinus officinalis L. extracts to evaluate its anti-aging effects in a mouse model of skin aging. Salvia officinalis and Rosmarinus officinalis are rich in polyphenols and antioxidants, protecting …

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