Konrad Reinhart

Exploring the triage accuracy of the Manchester Triage System and the Emergency Severity Index in emergency department patients with sepsis: A secondary retrospective analysis

Philipp Schondelmaier, Anna Slagman, Martin Möckel, Antje Fischer‐Rosinsky et autres

Objetivos. Para cumplir el requisito de la guía Sepsis-3 de iniciar rápidamente el tratamiento, los sistemas de triaje de urgencias deben asignar a los pacientes con sospecha de sepsis a las categorías de triaje de mayor prioridad. El objetivo es explorar con …

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Sepsisversorgung in Deutschland: Qualitätsindikatoren zu Diagnostik und Therapie der Sepsis

Christian S. Scheer, Evgeny A. Idelevich, Simon Oelsner, Jacob Packmohr et autres

BACKGROUND: In Germany quality indicators from the Institute for Quality Assurance and Transparency in the Healthcare System (IQTIG) on the diagnostics and treatment of sepsis in hospitals will be compulsorily introduced in 2026. Currently, there are few data on the extent to …

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Think sepsis, write sepsis, code sepsis – patient characteristics associated with sepsis (under-)coding in administrative health data

Daniel O. Thomas-Rüddel, Norman Rose, Carolin Fleischmann-Struzek, Konrad Reinhart et autres

PURPOSE: Sepsis is a leading cause of morbidity and mortality, yet its documentation and coding in administrative health data remain unreliable. Accurate coding is essential for epidemiological surveillance, quality assurance, and reimbursement. This study aims to identify patient characteristics associated with under-diagnosis …

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Long-term outcomes after intensive care unit-treated COVID-19, influenza and respiratory sepsis in 2020 – a comparative, population-based cohort study

Franka E. A. Joost, Norman Rose, Aurelia Kimmig, Thomas Ruhnke et autres

BACKGROUND: Sepsis survivors are affected by a broad spectrum of long-term impairments, which overlap with Long-Covid and sequelae after influenza in their clinical presentation. However, we lack comparative assessments on the burden of long-term outcomes, particularly with patients being recruited from the …

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Computed tomography in patients with sepsis presenting to the emergency department: exploring its role in light of patient outcomes

Julian Pohlan, Martin M. Möckel, Anna Christine Slagman, Hannah Tenenbaum et autres

OBJECTIVES: This study aimed to explore the role of CT in septic patients presenting to the emergency department (ED). MATERIALS AND METHODS: We performed a retrospective secondary analysis of 192 septic patients from a prospective observational study, i.e., the "LIFE POC" study. …

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Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis

Carolin Fleischmann-Struzek, Lisa Mellhammar, Norman Rose, Alessandro Cassini et autres

PURPOSE: To investigate the global burden of sepsis in hospitalized adults by updating and expanding a systematic review and meta-analysis and to compare findings with recent Institute for Health Metrics and Evaluation (IHME) sepsis estimates. METHODS: Thirteen electronic databases were searched for …

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Re: Clinical Trials in Volume Resuscitation with Hydroxyethyl Starch: Focus on Risk of Bias.

Necmettin Ünal, Konrad Reinhart

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Postoperative Acute Kidney Injury and Blood Product Transfusion After Synthetic Colloid Use During Cardiac Surgery—A Response to Tobey et al

Konrad Reinhart

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Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions

Yannick Wirz, Angela R Branche, Michel Wolff, Tobias Welte et autres

Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to antibiotic overuse in this population of patients. Addition of procalcitonin, a blood biomarker expressed by epithelial …

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Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis

Didier Keh, Evelyn Trips, Gernot Marx, Stefan P. Wirtz et autres

Importance: Adjunctive hydrocortisone therapy is suggested by the Surviving Sepsis Campaign in refractory septic shock only. The efficacy of hydrocortisone in patients with severe sepsis without shock remains controversial. Objective: To determine whether hydrocortisone therapy in patients with severe sepsis prevents the …

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Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock

Frank Bloos, Evelyn Trips, Axel Nierhaus, Josef Briegel et autres

IMPORTANCE: High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis of sepsis, but effect on outcome is unclear. OBJECTIVE: To determine whether high-dose intravenous sodium selenite …

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Hospital Incidence and Mortality Rates of Sepsis: An Analysis of Hospital Episode (DRG) Statistics in Germany From 2007 to 2013

Carolin Fleischmann-Struzek, Michael E. Hartmann, Christiane S. Hartog, Tobias Welte et autres

BACKGROUND: Sepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around the world. To date, adequate data on the incidence and mortality of sepsis in Germany have been lacking. METHODS: Nationwide case-related hospital DRG statistics …

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