Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis
Rattachement africain : de, se, ch, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
PURPOSE: To investigate the global burden of sepsis in hospitalized adults by updating and expanding a systematic review and meta-analysis and to compare findings with recent Institute for Health Metrics and Evaluation (IHME) sepsis estimates. METHODS: Thirteen electronic databases were searched for studies on population-level sepsis incidence defined according to clinical criteria (Sepsis-1, -2: severe sepsis criteria, or sepsis-3: sepsis criteria) or relevant ICD-codes. The search of the original systematic review was updated for studies published 05/2015-02/2019 and complemented by a search targeting low- or middle-income-country (LMIC) studies published 01/1979-02/2019. We performed a random-effects meta-analysis with incidence of hospital- and ICU-treated sepsis and proportion of deaths among these sepsis cases as outcomes. RESULTS: Of 4746 results, 28 met the inclusion criteria. 21 studies contributed data for the meta-analysis and were pooled with 30 studies from the original meta-analysis. Pooled incidence was 189 [95% CI 133, 267] hospital-treated sepsis cases per 100,000 person-years. An estimated 26.7% [22.9, 30.7] of sepsis patients died. Estimated incidence of ICU-treated sepsis was 58 [42, 81] per 100,000 person-years, of which 41.9% [95% CI 36.2, 47.7] died prior to hospital discharge. There was a considerably higher incidence of hospital-treated sepsis observed after 2008 (+ 46% compared to the overall time frame). CONCLUSIONS: Compared to results from the IHME study, we found an approximately 50% lower incidence of hospital-treated sepsis. The majority of studies included were based on administrative data, thus limiting our ability to assess temporal trends and regional differences. The incidence of sepsis remains unknown for the vast majority of LMICs, highlighting the urgent need for improved epidemiological sepsis surveillance.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis
- Date Crossref
- 22/06/2020
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Jena University Hospital Center for Sepsis Control and Care pays non établi dans la noticeÉtablissement de santé
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Center for Sepsis Control and Care pays non établi dans la noticeStructure de recherche
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Lund University pays non établi dans la noticeUniversité ou école supérieure
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World Health Organization pays non établi dans la noticeOrganisme public
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University of Pittsburgh Department of Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Humboldt-Universität zu Berlin pays non établi dans la noticeUniversité ou école supérieure
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Berlin Institute of Health at Charité - Universitätsmedizin Berlin pays non établi dans la noticeStructure de recherche
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Freie Universität Berlin pays non établi dans la noticeUniversité ou école supérieure
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Charité - Universitätsmedizin Berlin pays non établi dans la noticeÉtablissement de santé
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University of Lund Department of Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Infection Prevention and Control Hub pays non établi dans la noticeInstitution
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Department of Anesthesiology and Operative Intensive Care Medicine (CCM pays non établi dans la noticeInstitution
Center for Sepsis Control and Care — Jena University Hospital, Center for Sepsis Control and Care et Lund University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.