Accès ouvert
2026
article
OpenAlex
Satoko Sasatsu, Yosuke Ono, Dai Miyashita, Tatsuya Yoshihara et autres
Background: Relugolix, an oral gonadotropin-releasing hormone (GnRH) antagonist, represents a potentially effective and less invasive therapeutic approach for retained products of conception (RPOC). However, its impact on subsequent pregnancy outcomes remains unclear. This study aimed to evaluate these outcomes following GnRH antagonist …
jp
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Tatsuya Yoshihara, Shinichiro Shinzaki, Tetsuji Naka, Hironobu Iijima et autres
Abstract Background Close monitoring of disease activity is essential for the therapeutic management of inflammatory bowel disease. A minimally invasive and reliable serum biomarker is desirable, but its reliability and validity have not yet been fully evaluated. The purpose of this study …
jp
(code pays fourni par la source)
2024
article
OpenAlex
Tatsuya Yoshihara, Keiko YAMAGUCHI, Junko Manabe, Atsuko MOROFUJI et autres
Since February 2024, an approximately 20-minute video has been used to explain the common content of Informed Consent Forms (ICF) in order to obtain consent to participate in clinical trials at SOUSEIKAI. We believe that the use of the video has many …
jp
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Makoto Uchiyama, Kazuo Mishima, Tomoko Yagi, Tatsuya Yoshihara et autres
Daridorexant is a dual orexin receptor antagonist for the treatment of insomnia. We report results from the first two randomised, double-blind clinical studies of daridorexant in Japanese subjects. In the Phase 1 study, daridorexant (10, 25, 50 mg) or placebo were administered …
jp, ch
(code pays fourni par la source)
2024
article
OpenAlex
Elisa Fabbrini, Brian Rady, Anastasiya Koshkina, Jae Yoon Jeon et autres
Homozygosity for the PNPLA3 risk allele is linked to liver fat accumulation. In phase 1 trials, JNJ-75220795, a hepatocyte-targeted GalNAc-conjugated PNPLA3 siRNA, reduced liver fat in PNPLA3 I148M homozygous patients with metabolic dysfunction–associated fatty liver disease.
us, jp
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Yuya Tsurudome, Yuya Yoshida, Kengo Hamamura, Takashi Ogino et autres
Prostaglandins are bioactive compounds, and the activation of their receptors affects the expression of clock genes. However, the prostaglandin F receptor (Ptgfr) has no known relationship with biological rhythms. Here, we first measured the locomotor period lengths of Ptgfr-KO (B6.129-Ptgfrtm1Sna) mice and …
jp
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Tatsuya Yoshihara, Yasuhiko Okuda, Osamu Yoshino
Objective Congenital uterine anomalies during pregnancy increase the risk of pregnancy complications such as miscarriage, preterm delivery, fetal malpresentation, cesarean delivery, and fetal growth restriction. However, few studies have examined uterine anomalies in relation to perinatal complications other than those mentioned above. …
jp
(code pays fourni par la source)
2023
article
OpenAlex
Satoshi Shinohara, Tatsuya Yoshihara, Kana Mochizuki, Genki Yasuda et autres
Abstract Aim This study aimed to clarify the factors influencing preeclampsia (PE) development in nulliparous Japanese women and to develop a PE prediction model using second trimester sonographic and clinical data readily available to obstetricians. Methods This historical cohort study examined the …
jp
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Gina Patel, Bibiana Castañeda-Ruiz, Tatsuya Yoshihara, Kevin M. Krause et autres
Abstract Background Epetraborole (EBO), an orally available bacterial leucyl transfer RNA synthetase inhibitor with potent activity against nontuberculous mycobacteria, is under clinical development for treatment-refractory MAC lung disease. Nonclinical studies suggest that metabolism of EBO to metabolite M3 may involve oxidation by …
us, jp
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Masanari Shiramoto, Tatsuya Yoshihara, Wolfgang Schmider, Yoshinori Takahashi et autres
This phase 1 study compared the pharmacokinetic (PK) and glucose pharmacodynamic (PD) characteristics of biosimilar SAR342434 insulin lispro and Japan-reference Humalog insulin lispro. This was a randomized, double-blind, 2-period, crossover study. Thirty-six healthy Japanese male subjects underwent a 10-hour euglycemic clamp following …
jp, fr, de
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Masanari Shiramoto, Tatsuya Yoshihara, Wolfgang Schmider, Hiroki Takagi et autres
Abstract This study compared the pharmacokinetic and glucodynamic profiles of biosimilar SAR341402 insulin aspart to Japan-approved insulin aspart (NovoRapid) in healthy Japanese males. In this single-center, randomized, double-blind, single-dose, two-period, crossover study, subjects received 0.3 U/kg of SAR341402 or NovoRapid before undergoing …
jp, de, fr
(code pays fourni par la source)
2021
article
OpenAlex
Mei Tsuchida, Nako Komura, Tatsuya Yoshihara, Yuta Kawasaki et autres
Although it is well known that the ovulation occurs during a period of time after LH surge in dogs, there are few reports of observing the entire process of development, ovulation and luteinization of each follicle. This study aimed to detect the …
jp
(code pays fourni par la source)