Accès ouvert
2026
article
OpenAlex
Nobuhiro Fujiyama, Ayuto Kodama, Marco M. Z. Sharkawi, Kazuo Mishima et autres
This study evaluated the utility of a smartphone-based walking-speed application for early mild cognitive impairment (MCI) screening under every day, real-world conditions. Community-dwelling adults aged ≥ 65 years were recruited from dementia prevention activities in Yokote City, Akita Prefecture, (entry period: October …
jp, Égypte
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Accès ouvert
2026
article
OpenAlex
Sachiko Tanaka‐Mizuno, Kenichi Fujimoto, Kazuo Mishima, Yukinori Sakata et autres
STUDY OBJECTIVES: To investigate the prescription patterns for hypnotics among patients <18 years in Japan. METHODS: We conducted a descriptive epidemiologic study using a claims database in Japan. We included patients aged 0-17 years with first-time prescriptions for hypnotics between June 2021 …
jp, us
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Accès ouvert
2026
preprint
OpenAlex
Taku Miyagawa, Mihoko Shimada, Kotomi Tanida, Nozomu Kotorii et autres
Abstract Idiopathic hypersomnia (IH) is a rare and heterogeneous sleep disorder characterized by excessive daytime sleepiness. We aimed to stratify IH patients based on polygenic risk scores (PRSs) for sleep-related traits and explored the underlying genetic predispositions. Genome-wide single-nucleotide polymorphism data from …
jp, Zambie
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Accès ouvert
2026
article
OpenAlex
Atsushi Iwasawa, Kyoko Nomura, Junko Hirayama, Takumi Kimura et autres
The COVID-19 pandemic has severely impacted university students' mental health, increasing depressive symptoms and suicidal ideation.We developed a 48-minute video for training student suicide gatekeepers.This study was to evaluate the usefulness of a gatekeeper training video in enhancing university students' suicide prevention …
jp
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2025
article
OpenAlex
Kazuo Mishima
Sleep-waking is regulated by numerous sleep- and wake-promoting nuclei in the brain and biological clocks (suprachiasmatic nucleus). In dementia, organic damage occurs in the brainstem, hypothalamus, and thalamus, where these nuclei and their neural projections are concentrated, resulting in severe insomnia, hypersomnia, …
jp
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Accès ouvert
2025
article
OpenAlex
Nana Shibata, Kazuhisa Yoshizawa, Masahiro Takeshima, Shingo Kitamura et autres
Aim: To investigate the relationship between the prescription of novel hypnotics (melatonin receptor agonists [MRAs] and orexin receptor antagonists [ORAs]) and the risk of hip fractures in a large cohort of Japanese patients. Methods: In this retrospective study, we analyzed data from …
jp
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Accès ouvert
2025
article
OpenAlex
Yuki Motomura, Shingo Kitamura, Kentaro Oba, Ruri Katsunuma et autres
Purpose: This study examined the neural correlates in functional brain connectivity common to subjective and objective sleepiness. Because functional connectivity can be measured at rest and during tasks, it is well suited for exploring the commonalities between sleepiness during psychomotor vigilance task …
jp
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Accès ouvert
2025
article
OpenAlex
Naoko Ayabe, Isa Okajima, Wataru Yamadera, Hisateru Tachimori et autres
Background: Insomnia is a quality of life (QOL) disorder complicated by various mental or physical daytime dysfunctions in addition to nocturnal insomnia symptoms. This study aimed to develop and examine the reliability and validity of a self-administered scale that can sensitively and …
jp
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Accès ouvert
2025
article
OpenAlex
Junichiro Hayano, Masahiro Takeshima, Aya Imanishi, Masaya Ogasawara et autres
Abstract We previously demonstrated that sleep apnea (SA) can be detected using acceleration and gyroscope signals from smartwatches. This study investigated whether an inertial measurement unit (IMU) embedded in non-wristwatch devices, such as smartphones, can also detect SA when worn during sleep. …
jp
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Accès ouvert
2025
article
OpenAlex
Yuji Yamada, Naoko Kishimoto, Hiromi Tagata, Tsubasa Morimoto et autres
Objective: Schizophrenia mainly begins in adolescence and leads to impairments of social functioning. Alterations in the immune system, as represented by cytokine levels, has been linked to the pathophysiology of schizophrenia. Among a variety of cytokines, transforming growth factor-β (TGF-β) plays a …
jp
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Accès ouvert
2025
conference-abstract
OpenAlex
Masahiro Takeshima, Kazuhisa Yoshizawa, Masaya Ogasawara, Yu Itoh et autres
Abstract Background Long-term prescriptions of hypnotics is a worldwide problem. In Japan, medical fee reductions were implemented thrice between 2012 and 2018 to promote the appropriate use of hypnotics (2012 and 2014 for polypharmacy of three or more hypnotics, 2018 for long-term …
jp
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Accès ouvert
2025
article
OpenAlex
Kazuo Mishima, Kenichi Fujimoto, Akira Endo, Mika Ishi
Abstract Background The competitive dual orexin receptor antagonist lemborexant (LEM) has been available in Japan as a treatment for insomnia since July 2020. The most commonly reported adverse event (AE) in phase 3 studies was somnolence. A post-marketing observational study (E2006-M081-501) was …
jp
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