Ana Pérez‐Ayala

Assessment of the PreventID Dermatophyte immunochromatographic test for diagnosing onychomycosis: Integration into routine clinical practice in a tertiary care hospital

María Victoria Castaño-Amores, Beatriz González Blanco, Maria Carmen Guevara Rodado, Ana Pérez‐Ayala

Onychomycosis is a common nail infection predominantly caused by dermatophytes. Accurate diagnosis is essential to guide antifungal therapy, yet conventional methods such as direct examination (DE) and fungal culture have important limitations, including operator dependence and long turnaround times. Rapid antigen-based assays, …

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Rezafungin for Salvage or Consolidation Therapy of Invasive Fungal Disease: Experience in Real‐World Clinical Practice

Jorge Boán, Eduardo Aparicio‐Minguijón, Mario Fernández‐Ruiz, María Asunción Pérez‐Jacoiste Asín et autres

BACKGROUND: Echinocandins are the first-line treatment for invasive candidiasis. Rezafungin is a novel echinocandin with improved pharmacokinetic properties that allow for once-weekly intravenous administration, offering potential advantages in complex clinical settings. OBJECTIVES: We aimed to describe our real-world experience with rezafungin for …

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False-positive results of the turbidimetric β-D-glucan assay in patients with bacteremia

Mario Fernández‐Ruiz, Ana Pérez‐Ayala, María Victoria Castaño Amores, Fernando Del Nogal Labrador et autres

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Azole resistance screening in Aspergillus fumigatus sensu stricto using the azole-containing agar method (EUCAST E.Def 10.2): conidial suspension filtration and inoculum adjustment before inoculum preparation may not be needed

Julia Serrano‐Lobo, Patricia Muñóz, Pilar Escribano, Jesús Guinea et autres

ABSTRACT Azole resistance screening in Aspergillus fumigatus sensu stricto can be routinely carried out by using azole-containing agar plates (E.Def 10.2 procedure); however, conidial suspension filtering and inoculum adjustment before inoculum preparation are time-consuming. We evaluated whether skipping the filtration and inoculum …

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Fluconazole‐resistant Candida parapsilosis genotypes from hospitals located in five Spanish cities and one in Italy: Description of azole‐resistance profiles associated with the Y132F ERG11p substitution

Aína Mesquida, Eva Alcoceba, Eduardo Amaranto Jiménez Padilla, Aída Ramírez et autres

BACKGROUND: Fluconazole-resistant Candida parapsilosis is a matter of concern. OBJECTIVES: To describe fluconazole-resistant C. parapsilosis genotypes circulating across hospitals in Spain and Rome and to study their azole-resistance profile associated with ERG11p substitutions. PATIENTS/METHODS: We selected fluconazole-resistant C. parapsilosis isolates (n = …

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Trends in antifungal resistance in Candida from a multicenter study conducted in Madrid (CANDIMAD study): fluconazole-resistant C. parapsilosis spreading has gained traction in 2022

Judith Díaz-García, Marina Machado, Luís Alcalá, Elena Reigadas et autres

ABSTRACT We previously conducted a multicenter surveillance study on Candida epidemiology and antifungal resistance in Madrid (CANDIMAD study; 2019–2021), detecting an increase in fluconazole-resistant Candida parapsilosis . We here present data on isolates collected in 2022. Furthermore, we report the epidemiology and …

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Antifungal resistance in Candida spp within the intra-abdominal cavity: study of resistance acquisition in patients with serial isolates

Judith Díaz-García, Marina Machado, Luís Alcalá, Elena Reigadas et autres

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Non-Candida isolates from blood cultures and intra-abdominal samples: data derived from a multicentre prospective study conducted in Madrid

Judith Díaz-García, Ana Gómez, Marina Machado, Luís Alcalá et autres

Since most surveillance studies focus on candidaemia, non-Candida species such as Saccharomyces cerevisiae, Cryptococcus spp, Trichosporon spp, Rhodotorula spp, or Magnusiomyces spp, among others, have received little attention [1].Emerging non-Candida spp might account for up to 2.8% of fungaemia episodes [2][3][4][5][6] and …

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Correction: Díaz-García et al. Candida Genotyping of Blood Culture Isolates from Patients Admitted to 16 Hospitals in Madrid: Genotype Spreading during the COVID-19 Pandemic Driven by Fluconazole-Resistant C. parapsilosis. J. Fungi 2022, 8, 1228

Judith Díaz-García, Ana Gómez, Marina Machado, Luís Alcalá et autres

In the original publication [...].

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Candida Genotyping of Blood Culture Isolates from Patients Admitted to 16 Hospitals in Madrid: Genotype Spreading during the COVID-19 Pandemic Driven by Fluconazole-Resistant C. parapsilosis

Judith Díaz-García, Ana Gómez, Marina Machado, Luís Alcalá et autres

Background: Candidaemia and invasive candidiasis are typically hospital-acquired. Genotyping isolates from patients admitted to different hospitals may be helpful in tracking clones spreading across hospitals, especially those showing antifungal resistance. Methods: We characterized Candida clusters by studying Candida isolates (C. albicans, n …

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Blood and intra-abdominal Candida spp. from a multicentre study conducted in Madrid using EUCAST: emergence of fluconazole resistance in Candida parapsilosis, low echinocandin resistance and absence of Candida auris

Judith Díaz-García, Ana Gómez, Marina Machado, Luís Alcalá et autres

OBJECTIVES: We prospectively monitored the epidemiology and antifungal susceptibility of Candida spp. from blood cultures and intra-abdominal samples in patients admitted to hospitals in the Madrid area. METHODS: Between 2019 and 2021, we prospectively collected incident isolates [one per species, patient and …

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Long-Term Follow-Up of Patients Diagnosed with COVID-19-Associated Pulmonary Aspergillosis (CAPA)

María Ruiz‐Ruigómez, Mario Fernández‐Ruiz, Ana Pérez‐Ayala, José María Aguado

COVID-19-associated pulmonary aspergillosis (CAPA) have been documented during the COVID-19 pandemic. The vast majority of these patients do not meet the classic EORTC/MSGERC criteria for invasive pulmonary aspergillosis. The question arises as to whether there may have been an over-diagnosis of this …

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