Yunpeng Wang

IL-6 signaling drives treg dysfunction and pathogenic Th1-like polarization in major depressive disorder

Yao Gao, Zihan Lei, Xianyan Zhan, Yifan Ren et autres

Major depressive disorder (MDD) is pathologically associated with inflammatory-immune dysregulation. While regulatory T cells (Tregs) are essential for immune homeostasis, clinical evidence have reported paradoxical dynamics (deficiency vs. expansion) of peripheral Tregs in MDD patients. The plasticity of Tregs and microenvironmental reprogramming …

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Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Binbin Zhao, Min Jia, Yan Zhao, Lu Ye et autres

Major depressive disorder (MDD) is a critical psychiatric illness with significant societal implications. The exact molecular mechanisms underlying MDD, specifically concerning cellular iron metabolism and ferroptosis, remain inadequately characterized. This study explores the regulatory function of astrocytic ferroptosis and its linkage to …

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Quality Assessment of Douyin as a Source of Information on Panic Attacks in China: Cross-Sectional Study (Preprint)

Ziyu Zhu, Wang Xi, Jiawen Wang, Fengjiao Liu et autres

BACKGROUND Panic attacks (PA), characterized by acute psychophysiological symptoms, affect 28% of adults globally. In China, with 1.04 billion short video users, Douyin plays a pivotal role in disseminating health information; however, the quality of PA-related content on this platform remains unassessed. …

Gut microbiota dysbiosis promotes cognitive impairment via bile acid metabolism in major depressive disorder

Min Jia, Yajuan Fan, Qingyan Ma, Ding Yang et autres

Evidence suggests that complex interactions among the gut microbiome, metabolic abnormalities, and brain have important etiological and therapeutic implications in major depressive disorder (MDD). However, the influence of microbiome-gut-brain cross-talk on cognitive impairment in MDD remains poorly characterized. We performed serum metabolomic …

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Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice

Ye Lu, Yijie Guo, Lulu Sun, Tong Liu et autres

Opioids abuse in adolescence is becoming a pressing public health issue. While evidence suggests that exposure to opioids during adolescence leads to lasting alterations in brain development, the long-term cognitive implications in adulthood remain uncertain. We developed a male mouse model of …

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Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in mice

Yunpeng Wang, Ye Lu, Yijie Guo, Lulu Sun et autres

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Kappa opioid receptor in nucleus accumbens regulates depressive-like behaviors following prolonged morphine withdrawal in mice

Jinyu Zhang, Ye Lu, Min Jia, Yuying Bai et autres

Prolonged withdrawal from opioids leads to negative emotions. Kappa opioid receptor (KOR) plays an important role in opioid addiction and affective disorders. However, the underlying mechanism of KOR in withdrawal-related depression is still lacking. We found that escitalopram treatment had a limited …

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Basolateral Amygdala SIRT1/PGC-1α Mitochondrial Biogenesis Pathway Mediates Morphine Withdrawal-Associated Anxiety in Mice

Fangyuan Yin, Jinyu Zhang, Yige Liu, Yifang Zhai et autres

BACKGROUND: Anxiety is a negative emotion that contributes to craving and relapse during drug withdrawal. Sirtuins 1 (SIRT1) has been reported to be critical in both negative emotions and drug addiction. However, it remains incompletely elucidated whether SIRT1 is involved in morphine …

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Characterizing serum amino acids in schizophrenic patients: Correlations with gut microbes

Qingyan Ma, Fengjie Gao, Lina Zhou, Yajuan Fan et autres

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Refined Deep Brain Stimulation of the Nucleus Accumbens Prevents Opioid Relapse: A Combined Treatment Based on Pathway- and Cell-Specific Circuits Involving the Kappa-Opioid Receptor

Yongsheng Zhu, Tengfei Ma, Yuanyuan Ji, Wei Dang et autres

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Modafinil rescues repeated morphine‐induced synaptic and behavioural impairments via activation of D1R–ERK–CREB pathway in medial prefrontal cortex

Fangyuan Yin, Jinyu Zhang, Ye Lu, Yulei Zhang et autres

Long-term opioid abuse causes a variety of long-lasting cognitive impairments such as attention, impulsivity and working memory. These cognitive impairments undermine behavioural treatment for drug abuse and lead to poor treatment retention and outcomes. Modafinil is a wake-promoting drug that shows potential …

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The role of SIRT1 in the basolateral amygdala in depression‐like behaviors in mice

Hao Guo, Cuola Deji, Han Peng, Jinyu Zhang et autres

Previous investigations have implicated the basolateral amygdala (BLA) epigenetic mechanisms in the pathophysiology of depression. SIRT1 is a NAD+-dependent class III histone deacetylase, widely expresses in BLA. However, epigenetic mechanisms in the BLA under the regulation of SIRT1 in the depression are …

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