Fengjie Gao

Sex differences in inflammation and gut–brain barrier dysfunction in adolescent depression: implications for predicting non-suicidal self-injury

Wenhui Jiang, Zixuan Zhang, Yajuan Fan, Lina Zhou et autres

Adolescent depression shows clear sex differences, with females having higher prevalence and more severe symptoms than males. The biological basis of these differences, particularly involving inflammation and the gut–brain axis, remains poorly understood. This study investigated sex-specific clinical and biological features and …

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SSRI-induced modulation of cytokines, barrier permeability, and BDNF in adolescent depression

Wenhui Jiang, Fengjie Gao, Yajuan Fan, Huanhuan Zhuo et autres

BACKGROUND: Emerging evidence links immune activation to antidepressant response in adolescents with major depressive disorder (MDD). We examined how depressive symptoms, quality of life (QOL), and blood markers of inflammation, blood–brain barrier (BBB) integrity, and gut permeability change following antidepressant treatment in …

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Double-hit of MIA and Nod2 deficiency induces sex-specific offspring behavioral abnormalities through placental dysregulation

Zhen‐Bo Cao, Xinyu Zhang, Fengjie Gao, Chuyao Wang et autres

Abstract The pathogenesis of neuropsychiatric disorders, including autism spectrum disorder and schizophrenia, originates from complex interactions between genetic susceptibility and early environmental exposure. Infectious challenges during pregnancy are well-known environmental risk factors for neurodevelopmental disorders. Our previous research reported the interplay between …

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Nod2 deficiency exacerbates schizophrenia-related alterations in offspring of maternal immune activation in a sex-dependent manner

Fengjie Gao, Chuyao Wang, Xinyu Zhang, Yixin Liu et autres

INTRODUCTION: Schizophrenia is a severe mental disorder with a complex etiopathogenesis involving both genetic and environmental risk factors. Evidence suggests that immune dysregulation plays a key role in its development, with maternal immune activation (MIA) during pregnancy identified as a significant environmental …

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Spatial Identification and Evaluation of Land Use Multifunctions and Their Interrelationships Improve Territorial Space Zoning Management in Harbin, China

Yafang Zhao, Jiafu Liu, Jie Zhang, Xiaonan Zhang et autres

Quantitative assessment and trade-off/synergy analysis of land use multifunctions can effectively identify regional conflicts and dominant functions, providing decision support for promoting sustainable socio-economic and land use development. However, current research in this field still faces challenges due to coarse scale of …

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Spatio-Temporal Fluctuation Analysis of Ecosystem Service Values in Northeast China over Long Time Series: Based on Bayesian Hierarchical Modeling

J.B. Song, Jiafu Liu, Xinyue Zhang, Xin Chen et autres

Ecosystems are undergoing continuous degradation due to the dual perturbation of global climate change and human activities, posing unprecedented threats and challenges to the ecosystem services they provide. To gain a deeper understanding of the spatio-temporal evolution of ecosystem service value (ESV), …

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Longitudinal Gut Microbiota Dysbiosis Underlies Olanzapine-Induced Weight Gain

豊田 隆謙, Xiaoyan He, Yixin Liu, Fengjie Gao et autres

UCG-001, that may play an important role in olanzapine-induced obesity. In this case, the supply or removal of specific elements of the gut microbiota may represent a promising avenue for treatment of olanzapine-related metabolic side effects.

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Optical coherence tomography angiography features in patients with idiopathic macular holes before and after vitrectomy

Xuemin Qi, Fengjie Gao, Xiaoming Gao

Abstract Purpose Optical coherence tomography angiography (OCTA) is a novel noninvasive imaging tool for retinal and optic nerve head (ONH) perfusion. The study aimed to explore OCTA features in patients with idiopathic macular holes (IMHs) before and after vitrectomy. Methods The retrospective …

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Characterizing serum amino acids in schizophrenic patients: Correlations with gut microbes

Qingyan Ma, Fengjie Gao, Lina Zhou, Yajuan Fan et autres

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Estimation of the bidirectional relationship between schizophrenia and inflammatory bowel disease using the mendelian randomization approach

Qian Li, Xiaoyan He, Fengjie Gao, Yajuan Fan et autres

Abstract It has been reported that schizophrenia (SCZ) and inflammatory bowel disease (IBD) are related. However, whether there is a bidirectional interaction between them remains unclear. The aim of this study was to conduct a bidirectional Mendelian randomization (MR) analysis to elucidate …

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Association between plasma proteome and childhood neurodevelopmental disorders: A two-sample Mendelian randomization analysis

Jian Yang, Xiaoyan He, Qian Li, Binbin Zhao et autres

Background Childhood neurodevelopmental disorders, including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS), comprise a major cause of health-related disabilities in children. However, biomarkers towards pathogenesis or novel drug targets are still limited. Our study aims to provide …

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Multi-Omics Analysis Reveals Aberrant Gut-Metabolome-Immune Network in Schizophrenia

Yajuan Fan, Yuan Gao, Qingyan Ma, Zai Yang et autres

Schizophrenia (SCZ) is associated with several immune dysfunctions, including elevated levels of pro-inflammatory cytokines. Microorganisms and their metabolites have been found to regulate the immune system, and that intestinal microbiota is significantly disturbed in schizophrenic patients. To systematically investigate aberrant gut-metabolome-immune network …

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