IL-6 signaling drives treg dysfunction and pathogenic Th1-like polarization in major depressive disorder
Yao Gao, Zihan Lei, Xianyan Zhan, Yifan Ren et autres
Major depressive disorder (MDD) is pathologically associated with inflammatory-immune dysregulation. While regulatory T cells (Tregs) are essential for immune homeostasis, clinical evidence have reported paradoxical dynamics (deficiency vs. expansion) of peripheral Tregs in MDD patients. The plasticity of Tregs and microenvironmental reprogramming …
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