R.C. Jones

Urocortin-1 Is Chondroprotective in Response to Acute Cartilage Injury via Modulation of Piezo1

R.C. Jones, Kevin M. Lawrence, Scott M. Higgins, Stephen M. Richardson et autres

Post-traumatic OA (PTOA) is often triggered by injurious, high-impact loading events which result in rapid, excessive chondrocyte cell death and a phenotypic shift in residual cells toward a more catabolic state. As such, the identification of a disease-modifying OA drug (DMOAD) that …

gb (code pays fourni par la source)

Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models

Jean‐François Aubry, Oscar Bates, Christian Boehm, Douglas A. Christensen et autres

Computational models of acoustic wave propagation are frequently used in transcranial ultrasound therapy, for example, to calculate the intracranial pressure field or to calculate phase delays to correct for skull distortions. To allow intercomparison between the different modeling tools and techniques used …

Benchmark problems for transcranial ultrasound simulation: Datasets for intercomparison of compressional wave models

Jean‐François Aubry, Oscar Bates, Christian Boehm, Douglas A. Christensen et autres

This dataset contains the skull maps and modeling results associated with the forthcoming publication "Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models".

fr, gb, ch, us, cz, ca, fi, dk, cl (code pays fourni par la source)

Benchmark problems for transcranial ultrasound simulation: Datasets for intercomparison of compressional wave models

Jean‐François Aubry, Oscar Bates, Christian Boehm, Douglas A. Christensen et autres

This dataset contains the skull maps and modeling results associated with the forthcoming publication "Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models".

fr, gb, ch, us, cz, ca, fi, dk, cl (code pays fourni par la source)

Intergenerational play

Eifiona Thomas Lane, R.C. Jones, Rhiannon Little, Huw Meredydd Owen

Parc Pawb, or Everyone’s Park, is a slowly drawn vision of an improved and up-scaled play and leisure facility that had universal appeal, purposefully offering a wide range of locally determined features that benefit ‘all’ potential users of the play-space. The new …

Investigation of the chondrocyte response to varying mechanical load: assessment of impact stress

Scott M. Higgins, R.C. Jones, Kevin M. Lawrence, Stephen M. Richardson et autres

gb (code pays fourni par la source)

Radiotherapy-induced xerostomia: a randomised, double-blind, controlled trial of Visco-ease™ oral spray compared with placebo in patients with cancer of the head and neck

Claire Paterson, Maureen Thomson, Brian T. Caldwell, Rebekah Young et autres

gb (code pays fourni par la source)

Urocortin expression in cartilage is attenuated in a non-invasive mouse model of post traumatic osteoarthritis

Freija ter Heegde, R.C. Jones, T.R. Jackson, Clara De Pascale et autres

gb (code pays fourni par la source)

Piezo1 expression is increased in response to non-invasive impact of mouse knee joint

R.C. Jones, Freija ter Heegde, T.R. Jackson, Marie O’Brien et autres

gb (code pays fourni par la source)

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1

Kevin M. Lawrence, R.C. Jones, Thomas Jackson, Rachael L. Baylie et autres

Abstract Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its …

gb (code pays fourni par la source)

Chondroprotection by urocortin involves blockade of a mechanosensitive piezo1 ion channel: novel, exploitable pathways for the treatment and prevention of osteoarthritis?

Kevin M. Lawrence, R.C. Jones, T.R. Jackson, Rachael L. Baylie et autres

gb (code pays fourni par la source)

Urocortin protects chondrocytes from acute trauma in articular cartilage

R.C. Jones, T.R. Jackson, Ian Charles Locke, Stephen M. Richardson et autres

gb (code pays fourni par la source)