Nicholas An

Role of ferroptosis in radiation-induced soft tissue injury

Charlotte E. Berry, Carter B. Kendig, Nicholas An, Alexander Z. Fazilat et autres

Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reactive oxygen species, which harm nucleic acids, lipids, and proteins. While cancer …

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Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

Charlotte Elizabeth Berry, Camille Brenac, Caroline E. Gonzalez, Carter B. Kendig et autres

Throughout history, natural products have played a significant role in wound healing. Fibroblasts, acting as primary cellular mediators in skin wound healing, exhibit behavioral responses to natural compounds that can enhance the wound healing process. Identifying bioactive natural compounds and understanding their …

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Pharmacological and cell-based treatments to increase local skin flap viability in animal models

Charlotte Elizabeth Berry, Thalia Le, Nicholas An, Michelle Griffin et autres

Local skin flaps are frequently employed for wound closure to address surgical, traumatic, congenital, or oncologic defects. (1) Despite their clinical utility, skin flaps may fail due to inadequate perfusion, ischemia/reperfusion injury (IRI), excessive cell death, and associated inflammatory response. (2) All …

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QOL-12. “I’M JUST LIKE A BASKET FULL OF PROBLEMS”: QUALITATIVE STUDY OF COGNITIVE DYSFUNCTION AND QUALITY OF LIFE IN GLIOMA SURVIVORS

Kathleen Van Dyk, Lucy R. Wall, Benjamin M. Ellingson, Nicholas An et autres

Abstract For glioma survivors, cognitive impairment can be a central determinant of quality of life, but we need better understanding of their unique challenges and supportive care needs. In this qualitative study, we aimed to explore the post-treatment experiences of cognitive and …

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KUNBI-BOSHIN-HANGAM-TANG STIMULATES NITRIC OXIDE PRODUCTION THROUGH ACTIVATION OF NUCLEAR FACTOR-κB

Hyun Na Koo, Hyun‐Ja Jeong, Jeongsu Park, G. J. Moon et autres

The objective of the currently study was to determine the effect of Kunbi-Boshin-Hangam-Tang (KBH-Tang) on the production of nitric oxide (NO). Stimulation of RAW 264.7 cells with KBH-Tang after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in increased NO synthesis. KBH-Tang partially …

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Inhibition of tumor necrosis factor-α-induced apoptosis by Asparagus cochinchinensis in Hep G2 cells

Hyun Na Koo, Hyun‐Ja Jeong, Ja Yun Choi, Sung-Jin Choi et autres

kr (code pays fourni par la source)

Taraxacum Officinale Inhibits Tumor Necrosis Factor-α Production from Rat Astrocytes

H. M. Kim, Hye Young Shin, K. H. Lim, Sujin Ryu et autres

Substance P (SP) can stimulate production of tumor necrosis factor-alpha (TNF-alpha) from astrocytes stimulated with lipopolysaccharide (LPS). The objective of the current study was to determine the effect of Taraxacum officinale (TO) on the production of TNF-alpha from primary cultures of rat …

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The nitric oxide-producing properties of Solanum lyratum

H.M. Kim, M.J. Kim, E. Li, Yongqiang Lyu et autres

kr, cn (code pays fourni par la source)

INHIBITORY EFFECT OF MAST CELL-MEDIATED IMMEDIATE-TYPE ALLERGIC REACTIONS BY CICHORIUM INTYBUS

HYUNG MIN KIM, HYE WON KIM, Yeoung Su Lyu, JIN HEE WON et autres

kr, jp (code pays fourni par la source)

Action of Sosiho-Tang on Systemic and Local Anaphyls by Anal Administration

H. M. Kim, Y. Y. Kim, Hye-Yeon Jang, Seong‐Hee Moon et autres

The herbal formulation Soshiho-Tang (SS-Tang) has been used against allergic disease for generations, and still occupies an important place in traditional medicine in Korea. Previously, we reported that SS-Tang potently inhibited mast cell- mediated anaphylaxis when orally administered. In this study, we …

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Inhibitory effect of Anaphylactic Reaction of Sosiho-Tang

H. M. Kim, Y. Y. Kim, H. S. Moon, E. H. Lee et autres

Mast cells synthesize and secrete chemical mediators which play an central role in anaphylactic reactions. Compound 48/80 is a condensation product of formaldehyde with paramethoxyphenylethylamine that reliably induces the release of chemical mediators in the mast cell granules. Aggregation of the high-affinity …

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Expression of Glycosylphosphatidylinositol-Anchored NAD Glycohydrolase in Differentiated HL60 Cells by Phorbol Ester

Myung‐Kwan Han, Nicholas An, Uh‐Hyun Kim

kr (code pays fourni par la source)