Alexander Z. Fazilat

SP60. Insights Into Irradiation Effects on Vascular Tissues: Single-cell Transcriptional Analysis From Irradiated Internal Mammary Arteries and Aorta

Camille Brenac, Danae Kawamoto-Duran, Antonio Tomasso, M R Mohammadi Fallah et autres

PURPOSE: Despite advancements in oncology radiation, radiation-induced vascular damage remains a significant clinical challenge. Clinical studies indicate that patients previously treated with radiation therapy for various malignancies often experience significant alterations in their blood vessels, leading to radiation-induced fibrosis and vascular disease. …

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155. Decellularized Adipose Matrices and Fat Grafting in Wound Healing Following Radiation-induced Fibrosis

Camille Brenac, Kelly X. Huang, Charlotte E. Berry, Alexander Z. Fazilat et autres

PURPOSE: Radiation therapy has significantly improved mortality and remission rates for patients with cancer, yet radiation-induced fibrosis (RIF) remains a prevalent complication characterized by chronic ulceration, skin retraction, hypovascularity, and ischemic dermal necrosis. RIF induces apoptosis and fibroblast impairment, leading to delayed …

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Assessing the ability of ChatGPT to generate French patient-facing information to improve patient understanding in hand surgery

Camille Brenac, Danae Kawamoto-Duran, Alexander Z. Fazilat, Jaden G Tarter et autres

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Evaluating the quality and readability of ChatGPT-generated patient-facing medical information in rhinology

Alexander Z. Fazilat, Camille Brenac, Danae Kawamoto-Duran, Charlotte E. Berry et autres

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AI in plastic surgery: customizing care for each patient

Camille Brenac, Alexander Z. Fazilat, M R Mohammadi Fallah, Danae Kawamoto-Duran et autres

Artificial intelligence (AI) and machine learning (ML) involve the usage of complex algorithms to identify patterns, predict future outcomes, generate new data, and perform other tasks that typically require human intelligence. AI tools have been progressively adopted by multiple disciplines of surgery, …

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AI-based Cleft Lip and Palate Surgical Information is Preferred by Both Plastic Surgeons and Patients in a Blind Comparison

Alexander Z. Fazilat, Charlotte E. Berry, Andrew A. Churukian, Christopher V. Lavin et autres

IntroductionThe application of artificial intelligence (AI) in healthcare has expanded in recent years, and these tools such as ChatGPT to generate patient-facing information have garnered particular interest. Online cleft lip and palate (CL/P) surgical information supplied by academic/professional (A/P) sources was therefore …

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Role of ferroptosis in radiation-induced soft tissue injury

Charlotte E. Berry, Carter B. Kendig, Nicholas An, Alexander Z. Fazilat et autres

Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reactive oxygen species, which harm nucleic acids, lipids, and proteins. While cancer …

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Single-cell transcriptional analysis of irradiated skin reveals changes in fibroblast subpopulations and variability in caveolin expression

Lionel Kameni, Michelle Griffin, Charlotte E. Berry, Siavash Shariatzadeh et autres

BACKGROUND: Radiation-induced fibrosis (RIF) is an important late complication of radiation therapy, and the resulting damaging effects of RIF can significantly impact reconstructive outcomes. There is currently a paucity of effective treatment options available, likely due to the continuing knowledge gap surrounding …

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Deferoxamine topical cream superior to patch in rescuing radiation‐induced fibrosis of unwounded and wounded skin

Charlotte E. Berry, Darren Abbas, Michelle Griffin, Hendrik Lintel et autres

Topical patch delivery of deferoxamine (DFO) has been studied as a treatment for this fibrotic transformation in irradiated tissue. Efficacy of a novel cream formulation of DFO was studied as a RIF therapeutic in unwounded and excisionally wounded irradiated skin. C57BL/6J mice …

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24. Prevention Of Radiation-induced Ferroptosis In The Skin Alleviates Formation Of Chronic Fibrosis

Charlotte E. Berry, Michelle Griffin, Carter B. Kendig, Thalia Le et autres

Purpose: Radiation-induced fibrosis (RIF) is a debilitating sequelae of radiation therapy that has been shown to improve with topical treatment with the iron chelator deferoxamine (DFO). We investigated whether ferroptosis, a recently described type of iron-dependent pathway of cell death contributes to …

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Pharmacological and cell-based treatments to increase local skin flap viability in animal models

Charlotte E. Berry, Thalia Le, Nicholas An, Michelle Griffin et autres

Local skin flaps are frequently employed for wound closure to address surgical, traumatic, congenital, or oncologic defects. (1) Despite their clinical utility, skin flaps may fail due to inadequate perfusion, ischemia/reperfusion injury (IRI), excessive cell death, and associated inflammatory response. (2) All …

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Comparing and Analyzing the Accuracy, Comprehensiveness, and Clarity of AI-Based Microsurgical Patient-Facing Information Against Professional Organizations

Charlotte E. Berry, Alexander Z. Fazilat, Christopher V. Lavin, Hendrik Lintel et autres

Background: With the growing relevance of AI-based patient-facing information, a comparison was conducted between the accuracy, comprehensiveness, clarity, and readability of microsurgery-specific online information provided by professional organizations, specifically the American Society of Reconstructive Microsurgery (ASRM), and information generated by ChatGPT, an …

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