Jianfei Qian

Activating RARβ to overcome immunomodulatory drug resistance in t(4;14) human myeloma

Ling Zhong, Qiang Wang, Miao Xian, Jianfei Qian et autres

The t(4;14) translocation is a high-risk cytogenetic abnormality in multiple myeloma (MM) that results in overexpression of fibroblast growth factor receptor 3 (FGFR3) and enhanced MM proliferation, leading to poor prognosis. Herein, we carried out a high-throughput screen on 1855 Food and …

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All-trans retinoic acid and RARβ agonists enhance the efficacy of IMiD-based treatments for t(4;14) multiple myeloma

Ling Zhong, Qiang Wang, Miao Xian, Xiaobing Huang et autres

Abstract The t(4;14) (p16;q32) translocation stands as a formidable high-risk cytogenetic aberration in patients with multiple myeloma (MM). This genetic anomaly triggers the overexpression of fibroblast growth factor receptor 3 (FGFR3), which subsequently hijacks critical cell signaling pathways such as RAS/MAPK, JAK/STAT. …

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Novel DKK1-A2 CAR-T cell therpy for hematologic malignancies

Yufei Zhang, Wei Xiong, Jianfei Qian, Qing Yi

Abstract Background DKK1 (Dickkopf-1) is a secreted protein that acts as an antagonist of the Wnt/β-catenin signaling pathway. DKK1 overexpression has been observed in various tumors, especially in multiple myeloma. Conversely, DKK1 has limited expression in normal human tissues. This reciprocal expression …

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NPC1 as a novel therapeutic target for induction of pyroptosis in cancers

Chuanchao Zhang, Qiang Wang, Pan Su, Jianfei Qian et autres

BACKGROUND: Cholesterol metabolism reprogramming is a hallmark of cancer cells that exhibit cholesterol addiction by absorbing low-density lipoprotein (LDL) to generate cholesterol for growth. Yet the underlying mechanisms remain unclear. METHODS: We began by identifying Niemann-Pick C1 (NPC1) as a key cholesterol …

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Immunoprevention of triple-negative breast cancer with a novel multivalent vaccine

Sang Beom Lee, Jianfei Qian, Jing Pan, Shizuko Sei et autres

Triple-negative breast cancer (TNBC) is associated with a poor prognosis due to high recurrence rates and a lack of targeted therapies. Significant challenges in developing efficacious TNBC cancer vaccines are tumor antigen heterogeneity and the risk of antigen-negative variant escape, where target …

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Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8+ T cells activate host CD4+ T cells to control tumors with antigen loss

Liuling Xiao, Rui Duan, Wendao Liu, Chuanchao Zhang et autres

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Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors

Wei Xiong, Liuling Xiao, Rui Duan, Qiang Wang et autres

Background Cancer immunotherapy using immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, patients with multiple myeloma (MM) rarely respond to ICB. Accumulating evidence indicates that the complicated tumor microenvironment (TME) significantly impacts the efficacy of ICB therapy. Therefore, investigating how TME …

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P-285 Identifying Anti-Viral Drugs to Sensitize and Re-Sensitize MM Cells to Chemotherapy

Qiang Wang, Miao Xian, Liuling Xiao, Chuanchao Zhang et autres

P-068 Developing Novel DKK1-A2 CAR-T Cell Therapy for Myeloma and Other Hematologic Malignancies

Jianfei Qian, Wei Xiong, Liuling Xiao, Yufei Zhang et autres

Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis

Miao Xian, Qiang Wang, Liuling Xiao, Ling Zhong et autres

Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells in the bone marrow. MM patients with aggressive progression have poor survival, emphasizing the urgent need for identifying new therapeutic targets. Here, we show that the leukocyte immunoglobulin-like …

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Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors

Yong Lu, Qiang Wang, Gang Xue, Enguang Bi et autres

Abstract 2821: Development of therapeutic monoclonal antibodies against DKK1 peptide-HLA-A2 complex to treat human cancers

Jianfei Qian, Qiang Wang, Liuling Xiao, Wei Xiong et autres

Abstract Immunotherapy is a promising option for cancer treatment. Targeted immunotherapy with monoclonal antibodies (mAbs) is an effective and safe method for the treatment of malignancies. In recent years, efforts have been made to identify potential therapeutic mAbs by defining alternative or …

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