Lina Jin

A dual targeting BCMA and CD19 fastcar-t (GC012F/AZD0120) as first-line therapy for newly diagnosed multiple myeloma

Juan Du, Wanting Qiang, Jing Lu, Yanchun Jia et autres

Abstract Background GC012F/AZD0120 is an autologous CAR-T therapy that targets both B cell maturation antigen (BCMA) and CD19. It is developed using the novel FasTCAR-T platform, which allows for next-day manufacturing. GC012F/AZD0120 has demonstrated deep and durable responses with a manageable safety …

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A first-in-human study of CT0596, an allogeneic CAR T-cell therapy targeting BCMA, in patients with relapsed/refractory multiple myeloma

Juan Du, Lina Jin, Wanting Qiang, Pei Guo et autres

Abstract Introduction Universal CAR T-cell therapy addresses key challenges of autologous CAR T, including high cost, time-consuming, personalized manufacturing and manufacturing failure risks. CT0596 is an allogeneic BCMA-targeting CAR T-cell therapy developed on the THANK-u PlusTM platform. It incorporates the knockout of …

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Clinical and genomic features of macrofocal multiple myeloma: a distinct profile

Jin Liu, Jianling Fan, Xinyi Zhou, Xi Chen et autres

Not available.

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Cocoa butter-sodium caseinate-gum arabic ternary complex enhances spray-drying survival and digestive tolerance of Lactiplantibacillus plantarum

Jia Liu, Lulu Liu, Lina Jin, Yuqing Zhao et autres

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GPRC5D-targeted CAR T-cell therapy (CT071) in patients with relapsed or refractory multiple myeloma: a first-in-human, single-centre, single-arm, phase 1 trial

Lina Jin, Siyu Gu, Qianqi Ruan, Jing Lu et autres

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High-level production of Tauroursodeoxycholic acid from Taurochenodeoxycholic acid in engineered Bacillus subtilis via whole-cell biotransformation

Lina Jin, Tengfei Niu, Rufeng Wang, Li Yang et autres

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Structure-guided single-point mutagenesis and carboxyl-terminal truncation improved the substrate selectivity of 7α-hydroxysteroid dehydrogenase

Lina Jin, Min Chen, Li Yang, Shujuan Zhao et autres

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First-in-Human Study of GPRC5D-Targeted CAR T-cell Therapy CT071 with an Accelerated Manufacturing Process for the Treatment of Relapsed/Refractory Multiple Myeloma

Lina Jin, Siyu Gu, Qianqi Ruan, Jing Lü et autres

MicroRNA-593-3p Inhibits Growth and Metastasis of Human Breast Cancer Cells by Regulating TIMM17A Expression

Zhigang Yang, Jun Zhang, Liguo Yang, Chenzeyue Qian et autres

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Association of BCMA-Targeted CAR-T Cell Therapy and the Gut Microbiome in Multiple Myeloma

Xiaoxiang Wang, Xiaoli Hu, Miaomiao Pan, C.-W. Qian et autres

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Cocoa Butter-Sodium Caseinate-Gum Arabic Ternary Complex Enhances Spray-Drying Survival and Digestive Tolerance of Lactobacillus Plantarum

Jia Liu, Lulu Liu, Lina Jin, Yuqing Zhao et autres

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GPRC5D-Targeted CAR T-Cell Therapy CT071 for the Treatment of Refractory/Relapsed Multiple Myeloma

Juan Du, Lina Jin, Siyu Gu, Jing Lü et autres

Introduction Despite significant progress in the therapeutic landscape for relapsed or refractory multiple myeloma (RRMM), the disease remains incurable. G protein-coupled receptor, class C, group 5, member D (GPRC5D) has emerged as a promising target, even for those who are refractory to …

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