Jing Lu

Discovery of NKT2152, a Potent and Selective HIF-2α Inhibitor with Favorable Pharmacokinetic Properties

Jiping Fu, Yigang He, Jing Lu, Hairong Wei et autres

Clear cell renal cell carcinoma (ccRCC) is driven in most cases (>80%) by inactivation of the von Hippel-Lindau (VHL) tumor suppressor, resulting in hypoxia inducible factor 2α (HIF-2α) accumulation and constitutive activation of downstream oncogenic pathways. Pharmacological inhibition of HIF-2α, exemplified by …

Abstract PS4-04-30: Discovery of NKT5097: a first-in-class, highly potent and selective, orally bioavailable CDK2/4 dual degrader for cancer therapy

Ke Liu, J. Geng, Zihang Yu, Y. Yeh et autres

Abstract CDK4 is the pivotal driver of HR+HER2- breast cancer and CDK4/6 inhibitors in combination with endocrine therapy have revolutionized the treatment landscape. However, several challenges remain for the approved CDK4/6 inhibitors, including severe hematotoxicity associated with CDK6 inhibition and eventual resistance, …

Targeting of HIF2-driven cachexia in kidney cancer

Muhannad Abu‐Remaileh, Laura A. Stransky, Nikita Bhalerao, Nitin H. Shirole et autres

Kidney cancer frequently causes paraneoplastic syndromes, including hypercalcemia and cachexia, but the underlying mechanisms are incompletely understood. The most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC), is frequently caused by loss of the pVHL tumor suppressor protein and …

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Academic Involution and Emotional Distress in Vocational College Students: A Moderated Mediation via Perceived Stress and Psychological Resilience

Jing Lu

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A dual targeting BCMA and CD19 fastcar-t (GC012F/AZD0120) as first-line therapy for newly diagnosed multiple myeloma

Juan Du, Wanting Qiang, Jing Lu, Yanchun Jia et autres

Abstract Background GC012F/AZD0120 is an autologous CAR-T therapy that targets both B cell maturation antigen (BCMA) and CD19. It is developed using the novel FasTCAR-T platform, which allows for next-day manufacturing. GC012F/AZD0120 has demonstrated deep and durable responses with a manageable safety …

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Adolescent mobile phone addiction and psychological distress in Chinese adolescents: Chain mediation by self-control and academic procrastination and the moderating role of family functioning

Jing Lu, Pengfei Yue, Yu Sun

PURPOSE: Although previous studies have demonstrated that mobile phone addiction is associated with psychological distress among adolescents, the underlying mechanisms of this relationship remain insufficiently understood. This study aimed to explore the chain mediating roles of self-control and academic procrastination in the …

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Abstract A003: Baseline levels of HIF2 target proteins and response to the HIF2α inhibitor NKT2152 in patients with metastatic clear cell renal cell carcinoma

Berkay Simsek, Yasmin Nabil Laimon, Marc Machaalani, David H. McDermott et autres

Abstract Background Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau (VHL) gene, leading to hypoxia-inducible factor-2α (HIF2α) upregulation, which drives tumorigenesis. The HIF2α inhibitor (HIF2i) bezutifan is an approved treatment for metastatic ccRCC (mccRCC) and other …

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GPRC5D-targeted CAR T-cell therapy (CT071) in patients with relapsed or refractory multiple myeloma: a first-in-human, single-centre, single-arm, phase 1 trial

Lina Jin, Siyu Gu, Qianqi Ruan, Jing Lu et autres

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Accurate and Efficient Fetal Birth Weight Estimation from 3D Ultrasound

Jian Wang, Qiongying Ni, Hongkui Yu, Bin Zhang et autres

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HIF2-driven PTHrP Causes Cachexia and Hypercalcemia in Kidney Cancer: Treatment with HIF2 Inhibitors

Muhannad Abu‐Remaileh, Laura A. Stransky, Nikita Bhalerao, Nitin H. Shirole et autres

Abstract Kidney cancer frequently causes paraneoplastic syndromes, including hypercalcemia and cachexia, but the underlying mechanisms are incompletely understood. The most common form of kidney cancer, clear cell renal cell carcinoma, is frequently caused by loss of the pVHL tumor suppressor protein and …

us (code pays fourni par la source)

Nonclinical absorption, distribution, metabolism, excretion and biomarkers properties of a modified N-acetylgalactosamine–conjugated small-interfering RNA for hypercholesteremia

Dehu Dou, Jing Lu, Ali Fan, Xijing Chen

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Accurate and Efficient Fetal Birth Weight Estimation from 3D Ultrasound

Jian Wang, Qiongying Ni, Hongkui Yu, Bin Zhang et autres

Accurate fetal birth weight (FBW) estimation is essential for optimizing delivery decisions and reducing perinatal mortality. However, clinical methods for FBW estimation are inefficient, operator-dependent, and challenging to apply in cases of complex fetal anatomy. Existing deep learning methods are based on …

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