Jiamin Cheng

Convergent systemic therapy for liver metastases: Bridging primary tumor heterogeneity through shared pathways

Wenjing Wang, Caiyun Peng, Hongli Yu, Jiamin Cheng et autres

Liver metastases represent a major clinical challenge in oncology, often indicating advanced disease with complex management requirements. Despite originating from diverse primary tumors such as colorectal, pancreatic, and breast cancers, liver metastases exhibit shared biological behaviors influenced by the unique tumor microenvironment …

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Identification and Expression Characteristics of the vacuolar H+ pyrophosphatase Gene Family form Beta vulgaris L.

Yuzhu Cui, Shuai Wang, Jiamin Cheng, Yuxin Wang et autres

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Functionalized copper-depleting nanosponges for breast cancer dual starvation favoring dependent energy metabolism and angiogenesis

Siyu Chen, Xuan Wei, Meijuan Geng, Liyang Gong et autres

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A Multicenter Retrospective Study: Impact of First-Line Treatment Strategies on second-Line Efficacy and Safety of Regorafenib with or Without PD-1 Inhibitors in Unresectable Hepatocellular Carcinoma

Weihong Ma, Yinyin Li, Yinying Lu, Zhipeng Liang et autres

Purpose: Amid the era of targeted-immunotherapy for hepatocellular carcinoma (HCC), the selection of second-line therapy following failure of diverse first-line regimens remains inadequately explored. This multicenter study aimed to assess how first-line treatment strategies impact the efficacy and safety of second-line regorafenib-either …

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Efficacy and safety of regorafenib combination with PD-1 inhibitors vs. regorafenib monotherapy in second-line treatment for patients with unresectable hepatocellular carcinoma after failure of different first-line treatments: A multicenter retrospective real-world study.

Weihong Ma, Jiamin Cheng, Hongli Yu, Caiyun Peng et autres

4088 Background: Regorafenib is the first oral targeted drug as a second-line agent in patients with unresectable hepatocellular carcinoma (HCC) who progressed on sorafenib treatment.There is a lack of data to validate the second-line therapy after progression of targeted-immune combination therapy. Our …

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Delivery-Graded Programmable Micelles Achieve Enhanced Tumor Starvation through Combined Glutamine Deprivation and Angiogenesis Inhibition

Xuan Wei, Jiamin Cheng, Meijuan Geng, Siyu Chen et autres

The inhibition of dependent glutamine metabolism is an effective treatment for triple-negative breast cancer (TNBC) starvation, but it is limited by compensatory glycolysis and inadequate delivery efficiency. Herein, we construct a pH-responsive size/charge-reprogrammed micelle with hierarchical delivery characteristics for TNBC suppression with …

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GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma

Lijuan Qin, Jiuru Wang, Fang Cheng, Jiamin Cheng et autres

The placenta and tumors can exhibit a shared expression profile of proto-oncogenes. The basis of placenta-derived heat shock protein gp96, which induces prophylactic and therapeutic T cell responses against cancer including hepatocellular carcinoma (HCC), remains unknown. Here, we identified the associated long …

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Adaptive Full-Order Sliding-Mode Fault-Tolerant Control Method for Actuator Faults in Multi-Agent System

Yuanke Zhang, William Cai, Minghao Zhou, Jiamin Cheng et autres

In this paper, an adaptive full-order terminal sliding mode (FOTSM) control method is designed for fault-tolerant control of second-order non-linear multi-agent system (MAS) under actuator faults. Firstly, for the algebraic loop problem of the control system, an adaptive switching gain is added …

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Trace element variations of pyrite in orogenic gold deposits: Constraints from big data and machine learning

Genshen Cao, Yu Zhang, Hongtao Zhao, Jiamin Cheng et autres

Orogenic gold deposits represent key global gold resources, yet its internal differences are poorly constrained. Pyrite is ubiquitous in orogenic gold ores, and its trace element geochemistry has significant implications for the ore-forming processes. However, the diffusion regularity and controlling factors of …

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Supplementary Figure S3 from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

Chungang Liu, Limei Liu, Xuejiao Chen, Jiamin Cheng et autres

Lysine acetylation modification in LSD1 protein.

Data from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

Chungang Liu, Limei Liu, Xuejiao Chen, Jiamin Cheng et autres

Abstract Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood. In this study, we found that the chromatin modification factor LSD1 is highly …

Supplementary Figure Legends, Methods and References from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

Chungang Liu, Limei Liu, Xuejiao Chen, Jiamin Cheng et autres

Legends for Supplementary Figure S1-S7, and description of additional methods used in our study. Also includs Supplementary References.