Xuejiao Chen

Pan-cancer analysis combined with single-cell profiling reveals epigenetic and immune associations of ADH4 in hepatocellular carcinoma

Zhifeng Zhao, X T Chen, Xuejiao Chen, Bin Hu et autres

Background: Alcohol dehydrogenase 4 (ADH4) is an important enzyme involved in ethanol and retinol metabolism. Although altered ADH4 expression has been reported in several malignancies and has been suggested to have diagnostic or prognostic value, its broader significance across cancer types remains …

cn (code pays fourni par la source)

Evaluation of Local Tolerance of Structurally Different Olaflur Compounds

Junzhuang Chang, Shasha Wang, Jiaqi Shan, Xuejiao Chen et autres

cn (code pays fourni par la source)

Association of apolipoprotein E gene polymorphisms with risk of coronary artery disease in a Han Chinese population at middle and high altitude in China

Fanrong Zeng, Xinyi Zhang, Meng Zhang, Hongli Liu et autres

Introduction This study investigated the impact of APOE gene polymorphisms on the development of coronary artery disease (CAD) in the Han Chinese population at middle and high altitudes, focusing on lipid level regulation and atherosclerosis. Methods This retrospective case-control study involved 628 …

cn (code pays fourni par la source)

The relationship between METS-IR and the risk of diabetes incidence in rural adults in China: A retrospective cohort study based on dynamic population

Zihao Li, Xuejiao Chen, Wanli Hu, Gefei Li et autres

OBJECTIVE: To evaluate the longitudinal association between the Metabolic Score for Insulin Resistance (METS-IR) and the risk of diabetes mellitus in rural Chinese adults. METHODS: This retrospective cohort study included 53,120 participants aged ≥18 years from 2018 to 2023. Participants were stratified …

cn (code pays fourni par la source)

Transcriptome Data Reveals Hypoxic Adaptability on Embryonic Cardiac Development in Tibetan Chickens

Xuejiao Chen, Hailu Fan, Hao Zhang, Da Peng et autres

The Tibetan chicken (TC) is a small indigenous breed native to the Qinghai–Tibet Plateau in China, exhibiting remarkable adaptation to the plateau’s extreme high-altitude environment. Its strong hypoxia tolerance is reflected in the ability to maintain normal embryonic cardiac structure and function …

cn, mn (code pays fourni par la source)

An innovative engineered IL-10 monomer strengthens T cell-mediated anti-tumor responses through anti-PD-1 cis-delivery

Ce Gu, Jian-You Guo, Chang Zhou, Peipei Hu et autres

Immune checkpoint blockade (ICB) therapy exerts anti-tumor efficacy mainly by activating intratumoral CD8 + T cells but fails to re-activate terminally exhausted CD8 + T cells. Interleukin-10 (IL-10) has been shown to directly expand and activate these cells and to exert a …

gb, cn (code pays fourni par la source)

Comparative chromatin accessibility and transcriptome analyses identify key energy metabolism genes for hypoxia adaptation in embryos of Tibetan chickens

Xing Guo, Bo Zhang, Zihan Chen, Xuejiao Chen et autres

). After 16 days, RNA-seq was performed on 23 liver tissues from 13 Tibetan and 10 Leghorn chicken embryos. Six ATAC-seq datasets were also generated from three Tibetan and three Leghorn chickens, respectively. Differential expression analysis revealed that 2,421 genes were down-regulated …

cn (code pays fourni par la source)

Construction of a preoperative prehabilitation program for elderly esophageal cancer patients

Xuejiao Chen, Kun Zhou, Fengjuan Cai, Caifeng Luo et autres

Objective: To develop a prehabilitation program for elderly patients with esophageal cancer before surgery. Methods: Relevant studies on prehabilitation for esophageal cancer were comprehensively searched and analyzed to summarize the best available evidence. A preliminary prehabilitation program was drafted through group discussion …

cn (code pays fourni par la source)

Predictive and prognostic role of Neutrophil-to-Lymphocyte ratio in patients with advanced thyroid cancer treated with targeted therapy

Tuerhong Diliyaer, Xuejiao Chen, Xixi Zhu, Tuerxun Yilidana et autres

cn (code pays fourni par la source)

Performance of Prenatal Cell‐Free DNA Screening for Foetal Chromosome Aneuploidies and Microdeletion/Microduplication Syndromes: A Retrospective Study of 64,482 Consecutive Cases From a Prenatal Diagnosis Centre in China

Feiyan Pan, Xuejiao Chen, Yuanyuan Ying, Dandan He et autres

OBJECTIVE: Prenatal cell-free DNA (cfDNA) screening has shown high accuracy for common trisomies, but its application in screening for sex chromosome aneuploidies (SCAs), rare autosomal aneuploidies (RAAs) or microdeletion/microduplication syndromes (MMSs) requires more supportive data. METHODS: Between 2017 and 2023, a total …

cn (code pays fourni par la source)

Association Between Chinese Visceral Adiposity Index and Risk of Incident Hypertension Among Older Adults: A Prospective Cohort Study

Datian Gao, Xuejiao Chen, Dechen Liu, Donghai Su et autres

cn (code pays fourni par la source)

Investigating the effects of global gene knockout of MrgF on motor performance and pain sensitivity in mice

Xuejiao Chen, Yan Chen, Runzhe Shu, Shunyuan Lu et autres

Abstract Mas-related G protein-coupled receptors (Mrgs) are a subset of GPCRs linked to pain modulation. MrgF was identified as an orphan Mrg whose function and ligand remain unclear. In this study, in addition to its expression in the dorsal root ganglia (DRG), …

cn (code pays fourni par la source)