Jin He

Complement-secreting CAFs are associated with better prognosis in pancreatic cancer: single-cell multiomics

Kai Chen, Yongsu Ma, Liling Huang, Pengfei Wu et autres

BACKGROUND: Accumulating evidence has demonstrated that distinct tumour-promoting and tumour-restraining cancer-associated fibroblast (CAF) subtypes coexist in pancreatic ductal adenocarcinoma. OBJECTIVE: To develop targeted CAF therapeutic strategies by reprogramming tumour-promoting CAF subtypes. DESIGN: We leveraged multiomics technologies to systematically identify and characterise CAF …

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Research on the Rehabilitation Effect of Upper Limb Rehabilitation Robot Combined with Isokinetic Muscle Strength Training for Hemiplegic Patients in the Recovery Phase of Stroke

Jin He, Zhuowen Ding, Canqun He, Longfei Li

Objective: To explore the rehabilitation effect of upper limb rehabilitation robots combined with isokinetic muscle strength training on hemiplegic patients in the recovery phase of stroke, and to provide a more effective intervention plan for clinical rehabilitation treatment. Methods: One hundred and …

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Sa2048: MICROANATOMICAL ANALYSIS OF SURGICAL EXCISION BIOPSIES CAN DIFFERENTIATE AND QUANTIFY HISTOLOGIC FEATURES OF RECURRENT ACUTE AND CHRONIC PANCREATITIS

Lara Cheesman, Lucie Dequiedt, Mahya Faghih, Aida A. Metri et autres

417: T1 SIGNAL INTENSITY RATIO OF THE PANCREAS TO THE SPLEEN AND PARASPINAL MUSCLE PREDICTS FIBROSIS IN PATIENTS WITH RECURRENT ACUTE AND CHRONIC PANCREATITIS

Aida A. Metri, Mahya Faghih, Elizabeth A. Thompson, Rita R. Kalyani et autres

Mo1440: ASSOCIATIONS BETWEEN PATIENT HISTORY AND ADVANCED NEOPLASIA IN PATHOLOGY-PROVEN INTRADUCTAL PAPILLARY MUCCINOUS NEOPLASMS (IPMN)

Michel Almardini, Kylie Ning, Grace m. Kuo, Lindsey Manos et autres

Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding

Jin He, Xiaoxiao Yin, Tingting Yu, Lu Li et autres

OBJECTIVE: We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding. METHODS: Thirty-five women diagnosed with GDM were recruited, and fasting plasma samples were collected at ~6 …

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Abstract 4143940: Circulating Mitochondrial DNA: Biomarker and Inflammation Mediator in Cardiac Ischemia/Reperfusion Injury

Yuxin Chu, Yutao Hua, Lihao He, Yunxi Chen et autres

Introduction: Ischemia/reperfusion (I/R) injury occurs after coronary revascularization, contributing to infarct size. Circulating mitochondrial DNA (mtDNA) levels are elevated in acute myocardial infarction (MI) patients, and act as Damage Associated Molecular Patterns (mtDNA DAMP), which are recognized by the Toll-like receptor 9 …

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A few-shot learning framework for the diagnosis of osteopenia and osteoporosis using knee X-ray images

Hua Xie, Chenqi Gu, Wenchao Zhang, Jiacheng Zhu et autres

OBJECTIVE: We developed a few-shot learning (FSL) framework for the diagnosis of osteopenia and osteoporosis in knee X-ray images. METHODS: Computer vision models containing deep convolutional neural networks were fine-tuned to enable generalization from natural images (ImageNet) to chest X-ray images (normal …

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The secreted peptide BATSP1 promotes thermogenesis in adipocytes

Xianwei Cui, Hong Zhong, Yangyang Wu, Zhuo Zhang et autres

Although brown adipose tissue (BAT) has historically been viewed as a major site for energy dissipation through thermogenesis, its endocrine function has been increasingly recognized. However, the circulating factors in BAT that play a key role in controlling systemic energy homeostasis remain …

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Lipid Signature Changes of Women with Gestational Diabetes Mellitus in Response to Puerperal Exclusive Breastfeeding

Jin He, Lu Li, Yan Cui, Chen Jiang et autres

Previously, studies mainly focused on the relationship between long-term lactation and health-promoting effects on women with gestational diabetes mellitus (GDM). The favorable effects of short-term breastfeeding were often overlooked. We here investigated whether lactation during puerperium could help to reverse the diabetogenic …

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Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology

Sobuj Mia, Ravi Sonkar, Lamario Williams, Mary N. Latimer et autres

Circadian clocks temporally orchestrate biological processes critical for cellular/organ function. For example, the cardiomyocyte circadian clock modulates cardiac metabolism, signaling, and electrophysiology over the course of the day, such that, disruption of the clock leads to age-onset cardiomyopathy (through unknown mechanisms). Here, …

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β-Hydroxybutyrate Administered at Reperfusion Reduces Infarct Size and Preserves Cardiac Function by Improving Mitochondrial Function Through Autophagy

Yuxin Chu, Yutao Hua, Lihao He, Jin He et autres

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