Ravi Sonkar

Abstract Thu160: Cardiomyocyte Prolactin Signaling is Essential for Adaptation of the Heart to Pregnancy

Gobinath Shanmugam, Ravi Sonkar, Jun Cheng, Suresh K Verma et autres

Background: The heart adapts to pregnancy at transcriptional, metabolic, morphologic, and functional levels, ensuring that demands of both the mother and developing child are adequately met. How extra-cardiac signals coordinate cardiac adaptation to pregnancy is poorly understood. For various maternal tissues, including …

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Abstract Thu148: PDGFRβ Expression Marks a Multipotent Cardiac Fibroblast Population that Drives Fibrosis and Inflammation in Heart Failure

Tariq Hamid, Ameen Ismahil, Wei Liu, Yujie Zhu et autres

Fibrosis and inflammation are crucial for heart healing following ischemic injury, but their prolonged activation contributes to cardiovascular disease progression. While myofibroblasts are primarily thought to originate from cardiac fibroblasts in heart failure (HF), we previously identified the role of pro-fibrotic platelet-derived …

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Abstract Or112: Cardiac Macrophage are Key Immune Drivers of Cardiometabolic HFpEF

Mehak Goel, Ameen Ismahil, Ravi Sonkar, Shyam S. Bansal et autres

Heart failure with preserved ejection fraction (HFpEF) can develop with obesity, hyperinsulinemia, and glucose intolerance or type 2 diabetes, a phenogroup designated cardiometabolic HFpEF. While inflammation considered an important underlying mechanism, the role of innate immunity is poorly define. We investigated the …

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Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression

Ravi Sonkar, Hong Ma, David J. Waxman

Constitutive androstane receptor (CAR, Nr1i3), a liver nuclear receptor and xenobiotic sensor, induces drug, steroid, and lipid metabolizing enzymes, stimulates liver hypertrophy and hyperplasia, and ultimately, hepatocellular carcinogenesis. The mechanisms linking early CAR responses to later disease development are poorly understood. Here …

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Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: Primary and secondary gene responses with links to disease progression

Ravi Sonkar, Hong Ma, David J. Waxman

Abstract Constitutive Androstane Receptor (CAR, Nr1i3 ), a liver nuclear receptor and xenobiotic sensor, induces drug, steroid and lipid metabolizing enzymes, stimulates liver hypertrophy and hyperplasia, and ultimately, hepatocellular carcinogenesis. The mechanisms linking early CAR responses to subsequent disease development are poorly …

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Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology

Sobuj Mia, Ravi Sonkar, Lamario Williams, Mary N. Latimer et autres

Circadian clocks temporally orchestrate biological processes critical for cellular/organ function. For example, the cardiomyocyte circadian clock modulates cardiac metabolism, signaling, and electrophysiology over the course of the day, such that, disruption of the clock leads to age-onset cardiomyopathy (through unknown mechanisms). Here, …

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Augmented Cardiac Growth Hormone Signaling Contributes to Cardiomyopathy Following Genetic Disruption of the Cardiomyocyte Circadian Clock

Ravi Sonkar, Ryan Berry, Mary N. Latimer, Sumanth D. Prabhu et autres

Circadian clocks regulate numerous biological processes, at whole body, organ, and cellular levels. This includes both hormone secretion and target tissue sensitivity. Although growth hormone (GH) secretion is time-of-day-dependent (increased pulse amplitude during the sleep period), little is known regarding whether circadian …

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Pyrroloquinoline quinone attenuated benzyl butyl phthalate induced metabolic aberration and a hepatic metabolomic analysis

Jian Zhang, Catherine A. Powell, Sunitha Meruvu, Ravi Sonkar et autres

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Branched chain amino acids selectively promote cardiac growth at the end of the awake period

Mary N. Latimer, Ravi Sonkar, Sobuj Mia, Isabelle Robillard Frayne et autres

Essentially all biological processes fluctuate over the course of the day, manifesting as time-of-day-dependent variations with regards to the way in which organ systems respond to normal behaviors. For example, basic, translational, and epidemiologic studies indicate that temporal partitioning of metabolic processes …

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Impact of obesity on day‐night differences in cardiac metabolism

Sobuj Mia, Ravi Sonkar, Lamario Williams, Mary N. Latimer et autres

An intrinsic property of the heart is an ability to rapidly and coordinately adjust flux through metabolic pathways in response to physiologic stimuli (termed metabolic flexibility). Cardiac metabolism also fluctuates across the 24-hours day, in association with diurnal sleep-wake and fasting-feeding cycles. …

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Effect of Chronic Western Diets on Non-Alcoholic Fatty Liver of Male Mice Modifying the PPAR-γ Pathway via miR-27b-5p Regulation

Jian Zhang, Catherine A. Powell, Matthew Kay, Ravi Sonkar et autres

Western diets contribute to metabolic diseases. However, the effects of various diets and epigenetic mechanisms are mostly unknown. Here, six week-old C57BL/6J male and female mice were fed with a low-fat diet (LFD), high-fat diet (HFD), and high-fat high-fructose diet (HFD-HF) for …

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2310-PUB: Chronic Western Diets Initiate Fibrosis Progression in Nonalcoholic Fatty Liver of Male Mice Modifying the PPARγ Pathway via Mir-27b-5p Regulation

Jian Zhang, Catherine A. Powell, Matthew Kay, Ravi Sonkar et autres

Increased fructose intake in Western diets contributes to metabolic diseases. However, the epigenetic mechanisms are mostly unknown. Here, six week-old C57BL/6J male and female mice were fed with a low-fat diet (LFD), high-fat diet (HFD), and high-fat high-fructose diet (HFD-HF) for 20 …