Marie‐Christine Simon

Signatures in the gut microbiome of German elite athletes: insights from a matched-subgroup analysis

Claudia Lenz, Waldemar Seel, Theresa Dombrowski, Sebastian Hacker et autres

ABSTRACT Elite athletes undergo intense physical training and experience substantial physiological stress, which could affect the composition and function of their gut microbiome. This study compared the gut microbiomes of 148 German junior and senior elite athletes with those of 108 healthy …

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Development of a gut microbiota model for the analysis of bacterial modifications of xenobiotics

Natalie Hager, Jan-Lorenz Weyers, Marie‐Christine Simon, Waldemar Seel et autres

The human gut microbiota influences host physiology by metabolizing xenobiotics, such as drugs, dietary additives, and environmental contaminants. To enable standardized assessment of microbial xenobiotic metabolism, we established a defined bacterial colon model from pooled human fecal samples, by preparing clean bacterial …

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Social information about others' ratings influences food valuation and craving via mentalizingrelated brain activity

Ana Defendini, Daniela S. Schelski, Aline Simonetti, Marie‐Christine Simon et autres

Social influence is a key driver of changes in human diet, yet the brain mechanisms by which social information shapes food craving and food-related decision-making remain poorly understood. In this study, we tested the hypothesis that social information influences craving-related brain circuits …

Calorie-restricted oat diet is associated with zonulin and short-chain fatty acid response in metabolic syndrome: a randomized controlled trial

Linda Klümpen, Aakash Mantri, Anna Donkers, Waldemar Seel et autres

Oats are associated with positive effects on gut health, but human studies are largely lacking. Therefore, we investigated the effects of two different oat diets on gut permeability makers in individuals with metabolic syndrome, each in a randomized, controlled parallel design. Participants …

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Dataset: Replication files for: Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions, v2

Alina Malin Schieren, Hanna Huber, Mohamed Yaghmour, Christoph Thiele et autres

This repository contains original unprocessed data and code for the replication of our paper Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions from a Randomized Trial.

Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions

Alina Schieren, Hanna Huber, Carolina Alvarez-Garavito, Aakash Mantri et autres

Metabolic responses to dietary interventions often show high inter-individual variations, but the factors explaining these variations as well as underlying mechanisms and their interrelation remain largely unknown. Knowing which factors are relevant for the individual response to a dietary intervention and to …

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Differential effects of Nordic and Vegetarian diets on lipid metabolism, gut microbiome and cardiometabolic risk factors: A multi-omic perspective from a randomized clinical intervention trial

Hanna Huber, Alina Schieren, A.C.D. Donkers, Aakash Mantri et autres

ABSTRACT Background Beneficial effects of diets with predominance of plant-based foods as fruits, vegetables, whole grain and plant-protein and less animal-based foods, or so-called “ plant-based ” diets, on cardiometabolic risk have been reported. We aimed to examine the effects of two …

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Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality

Laura Schlautmann, Daniel Burgdorf, Shaunak Ghosh, Alina Schieren et autres

signaling and homeostasis and demonstrate a regulatory role of taste receptors in macrophages, enhancing our understanding of immune cell dysfunction in diabetes.

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Systemic Availability of Human Milk Oligosaccharides in Infants and Adults: A Narrative Review

Lars Bode, Stina Rikke Jensen, Yannik Bernd Schönknecht, Marie‐Christine Simon

Human milk contains many components with physiological effects beyond basic nutrition, including large quantities of structurally diverse oligosaccharides. Human milk oligosaccharides (HMOs) have been linked to health outcomes through microbiome-dependent and -independent mechanisms. To investigate the microbiome-independent effects of individual HMOs and …

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Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus

Thomas Skurk, Anja Bosy‐Westphal, Arthur Grünerbel, Stefan Kabisch et autres

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GLP‐1 Responses to a Single Meal Fortified With Oyster Mushroom Powder in Adults With Impaired Glucose Tolerance Depend on the Gut Microbiota Composition Before the Meal

Linda Klümpen, A.C.D. Donkers, Waldemar Seel, Lisa Dicks et autres

Fortification of a single meal with β-glucan-rich oyster mushroom (Pleurotus ostreatus) powder has been shown to increase the response of glucagon-like peptide 1 (GLP-1) and reduce concentrations of non-esterified fatty acids (NEFAs) in adults with impaired glucose tolerance (IGT). This secondary analysis …

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Empfehlungen zur Ernährungsprävention des Typ-2-Diabetes mellitus

Thomas Skurk, Arthur Grünerbel, Sandra Hummel, Stefan Kabisch et autres

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