Hao Yang

Bisphenol A promotes colorectal cancer malignancy through CXCL8 upregulation associated with p38 MAPK activation: A potential link to type 2 diabetes mellitus comorbidity

Wei Ao, Haoran Li, Yuhang Zhang, Zhenheng Wu et autres

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Clinical and genetic risk factors for anthracycline‑induced cardiotoxicity in Chinese early‑stage breast cancer patients: a candidate gene study

Shan Xu, Hao Yang, Nan Hu

PURPOSE: This study aimed to clarify the incidence of anthracycline-induced cardiotoxicity (ACT) and identify its clinical and candidate genetic risk factors in Chinese early-stage breast cancer patients, so as to provide evidence for clinical risk assessment and individualized cardiac protection. METHODS: This …

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Mechanistic study of ferulic acid in inhibiting fibrosis via promoting fibroblast apoptosis through Bcl-xL/caspase-3 signaling pathway

Yongfei Chen, Honglin Wu, Yuxi Zhou, Xue Wang et autres

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[Epidemiological Characteristics and Trends of HBV Among Blood Donors in Wuhan, 2016-2024].

Qin Yu, Ting-Ting Xu, Hao Yang, Xin Yu et autres

OBJECTIVE: To analyze the seroepidemiological characteristics and trends of hepatitis B virus (HBV) infection among blood donors in Wuhan from 2016 to 2024, providing data support for monitoring blood safety and evaluating the effectiveness of blood screening. METHODS: test was used to …

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A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models

Dongming Lv, Lei Ren, Zirui Zhao, Yanchao Rong et autres

Timely infiltration and effective turnover of macrophages after trauma are essential for wound regeneration. In pathological conditions, such as diabetic wounds, how disturbances in cellular collaboration leads to persistent inflammatory infiltration remains unclear. Herein, we identify that the expression of methionine adenosyltransferase …

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Synergistic changes in bystander CD8 and conventional CD4 T cells during neoadjuvant chemoimmunotherapy for non-small cell lung cancer reveal treatment response

Li Wu, Liying Yang, Jian Sun, Miaoqing Zhao et autres

Objective We analyzed changes in intratumoral CD8 + and CD4 + T-cell subpopulations following neoadjuvant chemoimmunotherapy in non-small cell lung cancer. We then assessed whether these alterations favored better outcomes and explored their association with the tumor microenvironment. Methods Paired pre- and …

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Multi-omics and experimental validation studies reveal key biomarkers of cellular senescence in diabetic retinopathy

Jinju Li, Hao Yang, Yixuan Lin, Zhaohui Fang

OBJECTIVE: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes, contributing to vision impairment and related retinal diseases. Growing evidence indicates that cellular senescence (CS) under high-glucose conditions plays a role in the pathogenesis of DR. This study aims to identify …

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Genomic characteristics and pathogenicity of three newly isolated NADC34-like PRRSV strains in China and evaluation of one strain for inactivated vaccine candidate

Hao Yang, Wenbo Song, Zhigang Li, Zhanwei Zhu et autres

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Experimental study on sprayable autologous epidermal cells for promoting full-thickness skin wound healing in diabetes

Xiaohui Li, Hao Yang, Honglin Wu, Shuting Li et autres

The technology of sprayable autologous epidermal cells has been proven effective in promoting epidermal regeneration and healing chronic refractory wounds. However, its underlying impact in diabetic wound healing remains less understood. The research aims to evaluate the effectiveness of this innovative therapy …

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[Investigation of Infection in HBV-Reactive Blood Donors in Wuhan].

Hao Yang, Qin Yu, Tingting Xu, Lei Zhao

OBJECTIVE: To investigate the pattern of hepatitis B virus (HBV) infection and the prevalence of hepatitis D virus (HDV) infection among voluntary blood donors who tested reactive for HBV in Wuhan, and to provide data support for the prevention and treatment of …

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A Quality by Design (QbD) Project of Human Dermal Fibroblast and its Therapeutic Effects on Managing Degenerative Intervertebral Disc Fibrosis in Rabbit and Cynomolgus Monkey

Li Zhou, Hongsheng Li, Chen Chen, Hao Yang et autres

Background: Low back pain (LBP) is the leading cause of disability among the elderly, placing significant social and economic burdens on societies globally. A common cause of chronic LBP is lumbar disc degeneration. Previously, we reported that autologous or allogenic fibroblast injections …

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Rare case report: a case of histological type transformation of lung cancer caused by neoadjuvant immunotherapy

Quanqing Li, Guangxin Zhang, Hao Yang, Jindong Li

Lung cancer remains the leading cause of cancer-related mortality, with 1.8 million deaths per year. Small cell lung cancer and non-small cell lung cancer (NSCLC) are the main cancer types. Approximately 85% of cases are NSCLC, including adenocarcinoma, squamous cell carcinoma, and …

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