Zirui Zhao

Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses

Ye Zhou, Tianyu Wang, Yiwen Fan, Wei Zhao et autres

Much attention has focused on commensal bacteria in health and disease, but the role of commensal viruses is largely unexplored. Although commensal viruses are suggested in some organs such as intestine to maintain tissue homeostasis, it is unknown whether they participate in …

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Topological Event Wavepackets in Energy‐Momentum‐Gapped Photonic Spacetime Crystals

Liang Zhang, Zirui Zhao, Qiaofei Pan, Chenhao Pan et autres

ABSTRACT We propose a new type of topological excitations—topological event wavepackets (TEWs)—that emerge in photonic spacetime crystals (STCs) with spatiotemporally modulated permittivity. TEWs exhibit strong spatiotemporal localization and are topologically protected by a fully opened energy‐momentum () gap, in which steady propagating …

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Stigmasterol suppresses macrophage extracellular traps and protects against septic liver injury via Nrf2–Pdhx-mediated metabolic remodeling

Jing Zhang, Dawei Xu, Zhihao Fan, Rui Xuan et autres

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Current Application Status of low glycemic load (LGL) Diet in Gestational Diabetes Mellitus (GDM)

Yashi Wang, Zirui Zhao

During pregnancy, gestational diabetes is the most common metabolic disorder disease, it has a serious impact on mothers and infants, and the rate of illness is also showing an up trend year by year. Although the traditional antiglycation drugs can control the …

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Bmal1 mediates nucleolin phase separation and prevents sepsis-induced myocardial dysfunction

Huiling Zhang, Yan Fang Xu, Tonggan Lu, Yu Zhang et autres

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A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models

Dongming Lv, Lei Ren, Zirui Zhao, Yanchao Rong et autres

Timely infiltration and effective turnover of macrophages after trauma are essential for wound regeneration. In pathological conditions, such as diabetic wounds, how disturbances in cellular collaboration leads to persistent inflammatory infiltration remains unclear. Herein, we identify that the expression of methionine adenosyltransferase …

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Topologically-protected superluminal pair annihilation in photonic time crystals

Liang Zhang, Chenhao Pan, He Jing, Danni Chen et autres

Photonic time crystals (PTCs) - dielectric media whose permittivity is periodically modulated in time - map to a Dirac equation with an imaginary mass, opening a momentum gap (k-gap) where modes grow or decay exponentially. Here, we introduce a sequence of temporal …

Generating and Weaving Topological Event Wavepackets in Photonic Spacetime Crystals with Fully Energy-Momentum Gapped

Liang Zhang, Zirui Zhao, Chenhao Pan, Cheng Qingqing et autres

We propose a novel type of topological excitation topological event wavepackets (TEWs) emerging in photonic spacetime crystals (STCs) with spacetime modulated dielectric constants. These TEWs exhibit strong spatiotemporal localization and are topologically protected by a fully opened energy momentum (ωk) gap, within …

Association and mediation between circulating inflammatory proteins and skin fibrosis

Zirui Zhao, Dongming Lv, Yanchao Rong, Zhongye Xu et autres

Objective Skin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating inflammatory proteins (CIPs) and skin fibrosis remains unclear. To investigate this potential association and mediated effect, Mendelian randomization (MR) and two-step MR were used. …

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SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota

Mengdi Chen, Yu Zhang, Liyan Hou, Zirui Zhao et autres

Strong evidence indicates that remodeling gut microbiota may be an effective approach to combat Parkinson's disease (PD). Scorpion Venom Heat-Resistant Synthesized Peptide (SVHRSP), a synthesized peptide discovered from scorpion venom, displays potent neuroprotection in multiple PD models. However, the potential mechanisms remain …

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Tailored Metal–Phenolic Network with Hypoglycemic Polyphenol for Promoting Diabetic Wound Healing

Yanchao Rong, Zirui Zhao, Dongming Lv, Rong H. Yin et autres

Diabetic foot ulcer is a common and serious complication of diabetes, with a high risk of amputation, recurrence, and mortality. Aiming at the characteristics of diabetic wounds and based on the result of network pharmacology, a tailored ligand cyanidin-3- O -glucoside (C3G) …

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Skin Microbiota, Immune Cell, and Skin Fibrosis: A Comprehensive Mendelian Randomization Study

Zirui Zhao, Yanchao Rong, Rong H. Yin, Zhongye Xu et autres

BACKGROUND: Microbiota dysbiosis has been reported to lead to leaky epithelia and trigger numerous dermatological conditions. However, potential causal associations between skin microbiota and skin fibrosis and whether immune cells act as mediators remain unclear. METHODS: Summary statistics of skin microbiota, immune …

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