Jinju Li

COVID-19 mRNA Vaccination Reduces Guillain-Barré Syndrome Risk: Evidence from a Large Longitudinal Cohort Study

Jinju Li, Yuanyi Pan, Yun Han, Chuan Zhou et autres

Abstract The association between COVID-19 vaccination and Guillain-Barré syndrome (GBS) has been previously investigated with inconsistent results, largely due to limited data and lack of concurrent controls. To address this problem, a large longitudinal cohort study was conducted using National COVID Cohort …

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Treatment‐Related Adverse Events and Associated Outcomes in Patients With Advanced Urothelial Carcinoma Treated With Enfortumab Vedotin: Analysis of the UNITE Study

Amanda Nizam, Charles B. Nguyen, Jinju Li, Emily Craig Zabor et autres

INTRODUCTION: Enfortumab vedotin-ejfv (EV), an antibody-drug conjugate approved for advanced urothelial carcinoma (aUC), has limited real-world safety data and no validated predictive biomarkers. Retrospective studies suggest higher objective response rates (ORR) among patients developing EV-related dermatologic toxicities, but survival implications remain unclear. …

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Multi-omics and experimental validation studies reveal key biomarkers of cellular senescence in diabetic retinopathy

Jinju Li, Hao Yang, Yixuan Lin, Zhaohui Fang

OBJECTIVE: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes, contributing to vision impairment and related retinal diseases. Growing evidence indicates that cellular senescence (CS) under high-glucose conditions plays a role in the pathogenesis of DR. This study aims to identify …

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SOX9 suppresses colon cancer via inhibiting epithelial-mesenchymal transition and SOX2 induction

Ying Feng, Ningxin Zhu, Karan Bedi, Jinju Li et autres

The Wnt/β-catenin pathway regulates expression of the SOX9 gene, which encodes sex-determining region Y-box (SOX) transcription factor 9, a differentiation factor and potential β-catenin regulator. Because APC tumor suppressor defects in approximately 80% of colorectal cancers (CRCs) activate the Wnt/β-catenin pathway, we …

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Deep learning-based optical coherence tomography and retinal images for detection of diabetic retinopathy: a systematic and meta analysis

Zoubin Bi, Jinju Li, Q Liu, Zhaohui Fang

Objective: To systematically review and meta-analyze the effectiveness of deep learning algorithms applied to optical coherence tomography (OCT) and retinal images for the detection of diabetic retinopathy (DR). Methods: We conducted a comprehensive literature search in multiple databases including PubMed, Cochrane library, …

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Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer

Amanda J. Broderick, Elizabeth Pan, Jinju Li, Alec Chu et autres

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A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance

Christopher E. Whitehead, Elizabeth K. Ziemke, Christy L. Frankowski-McGregor, Rachel A. Mumby et autres

Despite tremendous progress in precision oncology, adaptive resistance mechanisms limit the long-term effectiveness of molecularly targeted agents. Here we evaluated the pharmacological profile of MTX-531 that was computationally designed to selectively target two key resistance drivers, epidermal growth factor receptor and phosphatidylinositol …

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Repeat Next-Generation Sequencing Testing on Progression in Men With Metastatic Prostate Cancer Can Identify New Actionable Alterations

Joseph J. Park, Alec Chu, Jinju Li, Alicia Ali et autres

PURPOSE There are limited data available on the real-world patterns of molecular testing in men with advanced prostate cancer. We thus sought to evaluate next-generation sequencing (NGS) testing in the United States, focused on single versus serial NGS testing, the different disease …

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Abstract 1230: MTX-531, a first-in-class pan-PI3K inhibitor spares hyperinsulinemia yielding durable tumor regressions and resilience to adaptive resistance

Christopher E. Whitehead, Elizabeth K. Ziemke, Christy L. Frankowski-McGregor, Rachel A. Mumby et autres

Abstract Adaptive resistance mechanisms compromise the long-term effectiveness of kinase-targeted agents dictating the need for strategic combination approaches. MTX-531 was computationally designed to selectively target both PI3K and wild type EGFR. MTX-531 exhibits low nanomolar potency against the PI3K isoform family and …

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Using National COVID cohort collaborative (N3C) data to explore impact of COVID-19 infection on kidney function in patients receiving lithium therapy.

Yujia Tian, Anastasia K. Yocum, Jinju Li, Yongqun Oliver He et autres

Lithium is a drug primarily used to treat psychiatric disorders and has shown significant efficacy in treating bipolar disorder (BD) and major depressive disorder (MDD). Although lithium can stabilize emotional fluctuations and prevent the onset of depressive and manic episodes, case reports …

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Abstract PR03: Hypoxia promotes inflammatory fibroblast formation in pancreatic cancer

Ashley M. Mello, Tenzin Ngodup, Yusoo Lee, Katelyn L. Donahue et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by poor response to all existing therapies. Although immunotherapy has shown great promise against multiple deadly cancers, it has been largely ineffective in PDAC. This lack of response is in part attributed …

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Probabilistic learning of treatment trees in cancer

Tsung-Hung Yao, Zhenke Wu, Karthik Bharath, Jinju Li et autres

Accurate identification of synergistic treatment combinations and their underlying biological mechanisms is critical across many disease domains, especially cancer. In translational oncology research, preclinical systems, such as patient-derived xenografts (PDX), have emerged as a unique study design evaluating multiple treatments administered to …

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